Article
Immunology
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
Summary: This study found that in sickle cell disease, endothelial cell TLR4 expression, rather than hematopoietic cell TLR4, is crucial for initiating vaso-occlusive physiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Vasilios A. Morikis, Alfredo A. Hernandez, John L. Magnani, Markus Sperandio, Scott I. Simon
Summary: This article discusses the dual role of neutrophils in SCD and the mechanism of vascular occlusion associated with sickle cell disease. Regulation of neutrophil impact on patients through selectin-mediated integrin adhesive bond formation is highlighted.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Tim Jang, Maria Poplawska, Emanuela Cimpeanu, George Mo, Dibyendu Dutta, Seah H. Lim
Summary: VOC remains the most common reason for presentation in SCD patients, but current treatments to shorten VOC have had disappointing results. Exploration of the reasons for ineffective monotherapy and consideration of combination approaches with multiple agents may be necessary to target complex downstream pathways of VOC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Hematology
Connor Stewart, Tim Jang, George Mo, Nader Mohamed, Maria Poplawska, Ogechukwu Egini, Dibyendu Dutta, Seah H. Lim
Summary: The clinical use of hydroxyurea remains low among SCD patients in the US. Recent studies suggest a link between bacterial overgrowth, dysbiosis, and intestinal pathophysiological changes in SCD, affecting neutrophil aging and potentially contributing to vaso-occlusive crises. Understanding this relationship may lead to new antibiotic-based therapeutic approaches for modifying the clinical course of VOC in SCD.
Article
Hematology
Carlton D. Dampier, Marilyn Jo Telen, Ted Wun, R. Clark Brown, Payal Desai, Fuad El Rassi, Beng Fuh, Julie Kanter, Yves Pastore, Jennifer Rothman, James G. Taylor, David Readett, Krupa M. Sivamurthy, Brinda Tammara, Li-Jung Tseng, Jay Nelson Lozier, Helen Thackray, John L. Magnani, Kathryn L. Hassell
Summary: This study evaluated the efficacy and safety of rivipansel in vaso-occlusive crisis (VOC) requiring hospitalization. The results showed that rivipansel did not significantly impact the primary end point, but early treatment with rivipansel after pain onset can accelerate the resolution of acute VOC.
Article
Immunology
Alexander Leonardo Silva-Junior, Nadja Pinto Garcia, Evilazio Cunha Cardoso, Stephanny Dias, Andrea Monteiro Tarrago, Nelson Abrahim Fraiji, Matheus Souza Gomes, Laurence Rodrigues Amaral, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Erich Vinicius De Paula, Allyson Guimaraes Costa, Adriana Malheiro
Summary: Sickle Cell Anemia (SCA) is characterized by genetic mutation in the beta-globin gene leading to increased hemolysis rate and involvement of immunological molecules. This study analyzed levels of various molecules in SCA patients in different clinical conditions, identifying a pro-inflammatory profile in steady-state patients and highlighting specific molecules in VOC patients. PDGF-BB and IL-1ra were important markers for transitioning from acute to chronic stage, showing significant decrease after crisis inflammation and statistical difference in different patient groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Omika Katoch, Ramakrishna Ungalara, Tomasz Kaminski, Ziming Li, Rikesh K. Dubey, Isabella Burholt, Shweta Gudapati, Tirthadipa Pradhan-Sundd
Summary: The long-term effect of L-glutamine administration in the liver was investigated in humanized SCD mice. Chronic L-glutamine administration reduced hepatic hemoglobin-heme-iron levels but failed to ameliorate ischemic liver injury. This failure was found to be associated with reduced expression of hepatic Kupffer cells post-L-glutamine treatment.
Article
Medicine, General & Internal
Guillaume Feugray, Fiston Kasonga, Maximilien Grall, Ygal Benhamou, Victor Bobee-Schneider, Gerard Buchonnet, Sylvie Daliphard, Veronique Le Cam Duchez, Agnes Lahary, Paul Billoir
Summary: In this study, we found that a combination of routine laboratory biomarkers, including reticulocyte count, immature reticulocyte count, and fluorescent reticulocyte fraction at steady state, could be used to predict the development of vaso-occlusive crisis (VOC) in patients with sickle cell disease (SCD).
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Maria Poplawska, Dibyendu Dutta, Manjunath Jayaram, Moro Salifu, Ngee S. Chong, Seah H. Lim
Summary: The study found that both SCD patients and Townes mice show abnormalities in the intestines, which worsen rapidly after VOC induction, and are associated with increased intestinal microbial density. The results suggest that SCD and its complications, rather than hospitalization or medications, are responsible for the intestinal pathophysiological changes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Guillaume Feugray, Fiston Kasonga, Maximilien Grall, Cecile Dumesnil, Ygal Benhamou, Valery Brunel, Veronique Le Cam Duchez, Agnes Lahary, Paul Billoir
Summary: This study found that patients with sickle cell disease have a hypercoagulable state, and TGA parameters such as ETP and peak may be used to predict the development of vaso-occlusive crisis within 1 year.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Aafke E. Gaartman, Ajab K. Sayedi, Jorn J. Gerritsma, Tim R. Back, Charlotte F. Tuijn, Man Wai Tang, Harriet Heijboer, Koen Heer, Bart J. Biemond, Erfan Nur
Summary: Patients with sickle cell disease (SCD) are at risk of developing fluid overload due to intravenous fluid therapy (IV-FT) during treatment of vaso-occlusive crises (VOC). Factors independently associated with fluid overload include positive history of fluid overload, lactate dehydrogenase level, and top-up transfusion during admission. Despite previous history of fluid overload, adjustments to IV-FT are often not made, highlighting the need for more awareness and personalized approach to this complication.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Patrick C. Hines, Michael U. Callaghan, Ahmar U. Zaidi, Xiufeng Gao, Ke Liu, Jennell White, Michael Tarasev
Summary: The study found that adhesion of blood cells to P-selectin and VCAM1 is significantly increased on VOC days in patients with SCD. By establishing optimal cutoff values and a multimarker risk score, a better ability to identify VOC risk was demonstrated.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Cecile Karsenty, Venee N. Tubman, Chyong-jy Joyce Liu, Titilope Fasipe, Karla E. K. Wyatt
Summary: Placing CPNB for analgesia in pediatric SCD patients with opioid-refractory upper-extremity VOC can reduce opioid consumption, improve pain scores, and decrease length of hospitalization.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pediatrics
Jeanne Sigalla, Nathalie Duparc Alegria, Enora Le Roux, Artemis Toumazi, Anne-Francoise Thiollier, Laurent Holvoet, Malika Benkerrou, Sophie Dugue, Berengere Koehl
Summary: This study found that neuropathic pain (NP) is common during vaso-occlusive crises (VOC) in children with sickle cell disease (SCD), mostly occurring in the early stages of VOC. There were no significant differences in age, sex, and location of pain between patients with and without NP.
Article
Immunology
Chunliang Xu, Maria Gulinello, Paul S. Frenette
Summary: Sensory nerves play a protective role in SCD, relieving the severity of VOE, and manipulating nociception may provide a promising approach for treating SCD.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Danial Hassan, Tatheer Zahra, Ghid Kanaan, Muhammad Umair Khan, Kamran Mushtaq, Abdulqadir J. Nashwan, Pousette Farouk Hamid
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Urology & Nephrology
Abdulqadir J. Nashwan, Mohamed A. Yassin, Alaa Abd-Alrazaq, Farag Shuweihdi, Muftah Othman, Hanan F. Abdul Rahim, Mujahed Shraim
Summary: This review examines the prevalence of hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD). The findings suggest a high prevalence of severe hepatic iron overload in ESRD patients undergoing hemodialysis. Further research is needed to determine the impact of iron overload on vital organs and guide future studies in this field.
HEMODIALYSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Nissar Shaikh, Umm e-Amara, Athika Sajeer, Rohma Malik, Shoaib Nawaz, Shajahan Idayathulla, Abdul Gafoor M. Tharayil, Abdulqadir J. Nashwan
Summary: Laparoscopic surgery is the standard of care for various abdominal pathologies. However, unintentional injuries to intraabdominal organs and vessels caused by trocars and Veress needles can be rare yet potentially fatal complications. We present two cases of vascular laparoscopic entry injuries. Early recognition, aggressive resuscitation, and appropriate management of these injuries are vital for better outcomes.
INTERNATIONAL MEDICAL CASE REPORTS JOURNAL
(2023)
Review
Virology
Huzaifa Ahmad Cheema, Aruba Sohail, Areej Fatima, Abia Shahid, Muhammad Shahzil, Mohammad Ebad Ur Rehman, Rehmat Ullah Awan, Sampath Chinnam, Abdulqadir J. Nashwan
Summary: Currently approved therapies for COVID-19 have limitations such as low availability, high costs, and the need for trained medical personnel in a hospital setting. Quercetin, a cheap and accessible option, was evaluated in a meta-analysis to assess its effect on COVID-19 patients. The results showed that quercetin reduced the risk of intensive care unit admission and hospitalization but did not decrease the risk of all-cause mortality and the rate of no recovery. Further large-scale randomized controlled trials are needed to confirm these findings.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Virology
Santosh Kumar Sidhwani, Talat Mirza, Ambrina Khatoon, Fouzia Shaikh, Rizma Khan, Omer Ahmed Shaikh, Abdulqadir J. Nashwan
Summary: This study investigated the link between ACE2 gene polymorphisms and the severity of SARS-CoV-2. It found that SNP polymorphisms were associated with the severity of COVID-19, with rs2285666 SNP having a significant statistical link with gender and rs768883316 with age groups. Additionally, certain haplotypes were also significantly associated with severity.
Article
Ophthalmology
Luai Abu-Ismail, Mohammad Abuawwad, Mohammad J. Taha, Almu'atasim Khamees, Dima Y. Abu Ismail, Mohammad Sanwar, Yaqeen Al-Bustanji, Abdulqadir Nashwan, Omran Hamdan Alameri, Hamzeh Mohammad Alrawashdeh, Hashem Abu Serhan, Jocob Abu-Ismail
Summary: This study investigates the relationship between caffeine consumption, sleeping habits, use of electronic devices, and dry eye disease (DED) among medical students in Jordan. The results show that female gender, basic science years, and prolonged screen time significantly increase the risk of symptomatic DED.
CLINICAL OPHTHALMOLOGY
(2023)
Review
Obstetrics & Gynecology
Huzaifa Ahmad Cheema, Aamna Badar Ahmad, Muhammad Ehsan, Abia Shahid, Muhammad Ayyan, Saleha Azeem, Ayesha Hussain, Aden Shahid, Abdulqadir J. Nashwan, Mislav Mikus, Antonio Simone Lagana
Summary: This meta-analysis evaluated the efficacy and safety of tranexamic acid in low- and high-risk cesarean deliveries. The results showed that tranexamic acid can reduce blood loss and the need for blood transfusion, benefiting both low- and high-risk patients. However, there is still a lack of high-quality evidence to support its use.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Cardiac & Cardiovascular Systems
Nour Shaheen, Ahmed Shaheen, Mohamed Elmasry, Abdulqadir J. Nashwan
Summary: Endocardial-epicardial catheter ablation is more effective than endocardial catheter ablation alone in reducing the risk of ventricular arrhythmia recurrence in patients with structural heart disease, especially those with arrhythmogenic right ventricular cardiomyopathy and ischemic cardiomyopathy.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Nursing
Mohammad Alsadi, Islam Oweidat, Huthaifah Khrais, Ahmad Tubaishat, Abdulqadir J. Nashwan
Summary: This study aimed to investigate nursing students' satisfaction and self-confidence in simulation learning during the COVID-19 pandemic and found that students' ratings in these areas were relatively low.
Article
Nursing
Islam Oweidat, Ghada Abu Shosha, Kawther Dmaidi, Abdulqadir J. J. Nashwan
Summary: This study aimed to explore the relationship between patient safety culture and intent to leave among Jordanian nurses. The findings showed that nurses in Jordan had a 49.2% positive score for patient safety, with teamwork (65.3%) and handoff and exchange of information (62% each) scoring the highest, while staffing and workplace (38.1%) and response to error (26.6%) scoring the lowest. Moreover, the nurses had a strong intention to leave their jobs (M = 3.98). The study suggests that improving staffing patterns and increasing staff motivation through various methods can enhance patient safety culture, satisfaction, and nurse retention in Jordanian hospitals.
Article
Medicine, General & Internal
Jamsheer Parammal Alikutty, Anoop Raj, Sirajudheen K. Soofi, Amer A. Alkhateeb, Ahmed A. Soliman, Fawwaz R. Al Amiri, Ahmad A. Abujaber, Mohamed Zuhail K. Peediyakkal, Mohamad Khatib, Abdulqadir J. Nashwan
Summary: Acute kidney injury (AKI) is a serious condition caused by various factors, including rhabdomyolysis. In this case, a bodybuilder developed rhabdomyolysis-induced AKI after taking Ibuprofen for a fever. Multiple factors, such as muscle trauma, dehydration, infection, and drug toxicity, contributed to the development of AKI. Treatment typically involves aggressive fluid resuscitation, electrolyte replacement, and addressing the underlying cause. Early diagnosis and treatment are crucial for managing AKI successfully.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Khayry Al-Shami, Salman Almurabi, Jafar Shatnawi, Khaled Qasagsah, Ghayda Shatnawi, Abdulqadir J. Nashwan
Summary: Chlorine gas is a hazardous substance that can cause severe health effects when inhaled or exposed to the skin. The eyes are particularly sensitive to chlorine gas, and exposure can cause various symptoms, ranging from mild irritation to severe damage. It is important to be aware of the signs and symptoms of chlorine gas exposure and the potential long-term effects to take the necessary steps to protect oneself.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Aroma Naeem, Shehroze Tabassum, Saima Gill, Maleeka Z. Khan, Nimra Mumtaz, Qamoos Qaiser, Mubashar Karamat, Mashhood Arif, Farhan Naeem, Ahmed Afifi, Jawad Basit, Abdulqadir J. Nashwan
Summary: COVID-19 is a disease that not only affects the respiratory system but also can induce cardiac injuries such as myocardial infarction, myocarditis, and heart failure. Elevated levels of certain markers have been found in COVID-19-associated myocardial injuries. Various diagnostic modalities can be used to detect these cardiac pathologies.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Anood Alassaf, Khalid Mohamed, Abdullah Al Otaiby, Mohammad Al Wraidat, Abdulqadir J. Nashwan
Summary: This article describes a rare case of a 15-year-old patient with type 1 diabetes mellitus presenting with optic neuritis. Due to the potential hyperglycemia induced by steroids, managing the condition with steroids can be challenging. A multidisciplinary team approach is required to properly handle optic neuritis in these patients while avoiding steroid side effects.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Milad Shenno, Almonzer Al-Qiami, Ismail A. Ibrahim, Lojin Elhaw, Abdulqadir J. Nashwan
Summary: This report presents a rare case of a 19-year-old male with bilateral periventricular nodular heterotopia (PVNH) and an intra-axial pontine lesion. Unlike the common diffuse midline glioma, the patient's condition is more favorable, and the lesion is suspected to be a pilocytic astrocytoma. The final diagnosis was made based on clinical evaluation and various medical diagnostic tests, and management and follow-up were initiated.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2024)