Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders

Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease

(2022) Yi Li et al.   Fluids and Barriers of the CNS

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

(2021) Xue-Bing Ding et al.   NATURE MEDICINE

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

(2021) Sandro Da Mesquita et al.   NATURE

Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood

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Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human

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Meningeal lymphatic vessels regulate brain tumor drainage and immunity

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VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

(2020) Eric Song et al.   NATURE

Cerebrospinal fluid tracer efflux to parasagittal dura in humans

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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

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Safety of Intrathecal Administration of Gadolinium-based Contrast Agents: A Systematic Review and Meta-Analysis

(2020) Mihilkumar Patel et al.   RADIOLOGY

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

(2020) Jinman Chen et al.   Nature Communications

Identification of lymphatic endothelium in cranial arachnoid granulation-like dural gap

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Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols

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Glymphatic failure as a final common pathway to dementia

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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

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Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance

(2020) Weixi Feng et al.   Alzheimers Research & Therapy

Anatomical Features of the Deep Cervical Lymphatic System and Intrajugular Lymphatic Vessels in Humans

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Impaired meningeal lymphatic vessel development worsens stroke outcome

(2019) Pavel Yanev et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

(2019) Wenyan Zou et al.   Translational Neurodegeneration

Dural lymphatics regulate clearance of extracellular tau from the CNS

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MicroRNA based theranostics for brain cancer: basic principles

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Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients

(2019) Diana M. Byrnes et al.   Journal of Oncology

Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients

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Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension

(2019) Md Mahdi Hasan-Olive et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus

(2019) Per Kristian Eide et al.   BRAIN RESEARCH

Anatomy and function of the vertebral column lymphatic network in mice

(2019) Laurent Jacob et al.   Nature Communications

Lymphatic outflow of cerebrospinal fluid is reduced in glioma

(2019) Qiaoli Ma et al.   Scientific Reports

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

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Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study

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Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

(2018) Alex McCampbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice

(2018) Linmei Wang et al.   BRAIN PATHOLOGY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

Intrathecal administration of nusinersen in adolescent and adult SMA type 2 and 3 patients

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Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7

(2018) Chenchen Niu et al.   Science Translational Medicine

AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials

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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

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Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration

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Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET

(2017) Mony J. de Leon et al.   JOURNAL OF NUCLEAR MEDICINE

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Pharmacokinetics and Safety of Macrocyclic Gadobutrol in Children Aged Younger Than 2 Years Including Term Newborns in Comparison to Older Populations

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Outcome of Surgery for Idiopathic Normal Pressure Hydrocephalus: Role of Preoperative Static and Pulsatile Intracranial Pressure

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Structural and functional features of central nervous system lymphatic vessels

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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

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Amyloid-β efflux from the central nervous system into the plasma

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An Approach to Chemotherapy-Associated Toxicity

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Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

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Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus: Second Edition

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A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Accurate Detection of Outliers and Subpopulations With Pmetrics, a Nonparametric and Parametric Pharmacometric Modeling and Simulation Package for R

(2012) Michael N. Neely et al.   THERAPEUTIC DRUG MONITORING

Spontaneous Intracranial Hypotension: Dilemmas in Diagnosis

(2011) Maryam Rahman et al.   NEUROSURGERY

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

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Pharmacokinetics and Safety of Gadobutrol-Enhanced Magnetic Resonance Imaging in Pediatric Patients

(2009) Gabriele Hahn et al.   INVESTIGATIVE RADIOLOGY

SPECT/CT Fusion Imaging in Radionuclide Cisternography for Localization of Liquor Leakage Sites

(2009) Clemens Novotny et al.   JOURNAL OF NEUROIMAGING

Diagnostic Intracranial Pressure Monitoring and Surgical Management in Idiopathic Normal Pressure Hydrocephalus

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