Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2022.891731
Keywords
breast cancer; uncoupling protein; tumor immunity; tumor metabolism; thermal tomography
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Funding
- National Natural Science Foundation of China (NSFC) [81471781]
- National Major Scientific Instruments and Equipment Development [2012YQ160203]
- Guide Foundation of Renmin Hospital of Wuhan University [RMYD 2018M78]
- Nature Science Foundation of Hubei Province [2020CFB604]
- CSCO-Qilu Cancer Research Fund [Y-QL2019-0386]
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UCP1 and UCP2 play important roles in breast cancer, and are associated with prognosis, metabolism, and immune infiltration, with high expression having a positive impact on prognosis.
Background: Uncoupling protein 1 (UCP1) and UCP2 are associated with tumor metabolism and immunity. However, the prognostic value and molecular mechanisms underlying their action in breast cancer (BC) remain unclear.Materials and methods: In TCGA-BRCA cohort, we investigated the expression characteristics of UCP mRNAs, analyzed their prognostic value by Kaplan-Meier survival analysis, their potential molecular functions by gene set enrichment analysis, and their relationship with immune infiltrating cell types using TIMER and CIBERSORT, along with the assessment of their association with mutational profiles. Kaplan-Meier survival analysis was performed for UCPs in our cohort and their association with BC thermogenesis was assessed by thermal tomography.Results: High expression of UCP1 and UCP2 were positive prognostic markers for BC. UCP1 was associated with the impaired glucose metabolism, while UCP2 with enhanced anti-tumor immunity. High expressions of UCP1 and UCP2 were associated with CDH1 mutations. High UCP1 expression was associated with a high rate of thermogenesis in BC.Conclusions: These results implied a key role of UCP1 and UCP2 in prognosis, metabolism, and immune infiltration in BC. Further investigation of the relevant molecular mechanisms may provide new strategies for BC treatment.
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