Journal
PHARMACEUTICS
Volume 14, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics14071377
Keywords
Nitric oxide; hydrogel; wound dressing; chronic wounds
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UI/BD/150855/2021]
- FCT [UIDB/EQU/00102/2020, UIDP/EQU/00102/2020]
- Fundação para a Ciência e a Tecnologia [UI/BD/150855/2021] Funding Source: FCT
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This article discusses the application of nitric oxide in wound healing, with hydrogels being studied as carriers for storing and delivering NO, showing promising results in improving wound healing, controlling and sustaining NO release, and bactericidal properties.
Despite the noticeable evolution in wound treatment over the centuries, a functional material that promotes correct and swift wound healing is important, considering the relative weight of chronic wounds in healthcare. Difficult to heal in a fashionable time, chronic wounds are more prone to infections and complications thereof. Nitric oxide (NO) has been explored for wound healing applications due to its appealing properties, which in the wound healing context include vasodilation, angiogenesis promotion, cell proliferation, and antimicrobial activity. NO delivery is facilitated by molecules that release NO when prompted, whose stability is ensured using carriers. Hydrogels, popular materials for wound dressings, have been studied as scaffolds for NO storage and delivery, showing promising results such as enhanced wound healing, controlled and sustained NO release, and bactericidal properties. Systems reported so far regarding NO delivery by hydrogels are reviewed.
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