Article
Oncology
Pengpeng Zhang, Shengbin Pei, Jianlan Liu, Xiao Zhang, Yanlong Feng, Zeitian Gong, Tianyu Zeng, Jun Li, Wei Wang
Summary: In this study, a risk model based on cuproptosis-related long non-coding RNAs (CRlncRNAs) was constructed to classify lung adenocarcinoma (LUAD) patients into high and low-risk groups. Consensus clustering analysis was used to classify patients into different subtypes based on the CRlncRNAs in the model. Significant differences were observed in overall survival, tumor immune microenvironment, and mutation patterns among different risk groups and molecular subtypes. Functional experiments confirmed the impact of LINC00592 on LUAD cell proliferation, invasion, and migration.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Fangwei Wang, Hongsheng Lin, Qisheng Su, Chaoqian Li
Summary: This study found that 16 cuproptosis-related lncRNAs can accurately predict the prognosis of patients with LUAD, providing new insights into clinical applications and immunotherapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Guoliang Cui, Jinhui Liu, Can Wang, Renjun Gu, Manli Wang, Zhiguang Sun, Fei Wei
Summary: This study investigates the role of long noncoding RNAs in colon adenocarcinoma and establishes a prognostic signature consisting of six long noncoding RNAs. The study finds differences in prognosis, immune cell infiltration, and tumor mutation burden between different risk groups of COAD patients. Certain drugs are also identified to be more sensitive in the high-risk group.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Peiling Zhang, Guolong Liu, Lin Lu
Summary: In this study, a risk model consisting of 31 m6A-related lncRNAs with independent prognostic values in COAD was constructed and validated using TCGA data. The model demonstrates good performance in predicting prognosis and survival status, highlighting the critical roles of these lncRNAs in the tumor immune microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Xiaona Xie, Qianzi Liu, Xuehua Zhou, Rongtao Liang, Shengbo Yang, Min Xu, Haiyang Zhao, Chengye Li, Yanfan Chen, Xueding Cai
Summary: This study classified the raw data of lung adenocarcinoma patients and explored the connection between copper-dependent cell death and tumor development, prognosis, and immune response. A reliable CRG score was established to predict overall survival and a credible nomogram was created to enhance the clinical application of the CRG score and estimate the survival probability of patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dongming Li, Guangzhen Qu, Shen Ling, Yuanlin Sun, Yingnan Cui, Yingchi Yang, Xueyuan Cao
Summary: This study establishes a CRL signature related to cuproptosis for the prognosis prediction of COAD. High-risk patients with a higher CRL signature had a poorer prognosis. Immune cell infiltration, immune checkpoints, and RNA methylation modification genes were increased in high-risk patients. MAPK and Wnt signaling pathways were found to be associated with tumorigenesis. AKT inhibitors, ATRA, camptothecin, and thapsigargin showed higher sensitivity in high-risk patients. Overall, this CRL signature holds promise for prognostic prediction and targeted therapy in COAD.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Yufei Wang, Chen Zhang, Chengyue Ji, Wenli Jin, Xin He, Shunzhi Yu, Renhua Guo
Summary: Recent studies have identified different molecular subtypes of LUAD associated with cuproptosis-related genes, showing different prognoses. Patients with high cuproptosis scores had higher somatic mutation frequency and stemness scores, while patients with low cuproptosis scores had more immune infiltration and better prognosis. The cuproptosis score may serve as a promising biomarker to guide immunotherapy in LUAD.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Linfeng Li, Qidong Cai, Zeyu Wu, Xizhe Li, Wolong Zhou, Liqing Lu, Bin Yi, Ruimin Chang, Heng Zhang, Yuanda Cheng, Chunfang Zhang, Junjie Zhang
Summary: This study aimed to construct a prognostic signature based on cuproptosis-related lncRNA in LUAD and investigate its association with immunotherapy response. RNA-sequencing data, clinical information, and nucleotide variation of LUAD patients were obtained from the TCGA database. The prognostic signature was constructed using LASSO Cox regression, and its association with the tumor microenvironment (TME) and immunotherapy response was evaluated using various algorithms. Furthermore, the influence of lncRNA TMPO-AS1 overexpression on A549 cell line was assessed through in vitro experiments.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yuan Liu, Wei Lin, Ying Yang, JingJing Shao, Hongyu Zhao, Gaoren Wang, Aiguo Shen
Summary: The study discovered differentially expressed cuproptosis-related genes in LUAD patients and their prognostic value. A cuproptosis-related model was constructed to divide patients into high- and low-risk groups, and it was revealed that cuproptosis-related signatures influenced tumor prognosis by affecting tumor immunity. Additionally, potential diagnostic and therapeutic strategies for LUAD were provided through the prediction of small molecule compounds and the construction of a nomogram.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jinyan Wang, Zhonghua Tao, Biyun Wang, Yizhao Xie, Ye Wang, Bin Li, Jianing Cao, Xiaosu Qiao, Dongmei Qin, Shanliang Zhong, Xichun Hu
Summary: Our study investigated the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of colon adenocarcinoma (COAD). We found common genetic and transcriptional variations in COAD tissues and identified three cuproptosis molecular subtypes and three gene subtypes. Changes in multilayer CRGs were closely related to clinical characteristics, overall survival, signaling pathways, and immune cell infiltration of TME. We constructed a CRG Risk scoring system based on the expression of 7 key cuproptosis-related risk genes and found that high CRG risk scores were significantly associated with various TME characteristics, drug susceptibility, and patient survival. Finally, a highly accurate nomogram was developed to facilitate the clinical application of the CRG Risk scoring system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Chenyang Xu, Yonghao Liu, Yuxi Zhang, Ling Gao
Summary: This study identified the role of cuproptosis in colon cancer tumor microenvironment and immune responses. By analyzing differentially expressed cuproptosis-related genes, a signature was developed to accurately predict the prognosis of colon adenocarcinoma. Further analysis showed the association between cuproptosis and factors such as extracellular matrix and immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Wentao Zhang, Haizeng Qu, Xiaoqing Ma, Liang Li, Yanjun Wei, Ye Wang, Renya Zeng, Yuanliu Nie, Chenggui Zhang, Ke Yin, Fengge Zhou, Zhe Yang
Summary: This study aimed to create a survival prediction model for lung adenocarcinoma patients based on cuproptosis and immune-related genes, which can enhance personalized treatment. Through RNA sequencing analysis, key genes related to cuproptosis and immune response were identified, and a risk prognostic model was developed. The results showed significantly reduced survival rates in the high-risk group, along with lower levels of immune cell infiltration and immune checkpoint expression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yuchen Bai, Qi Zhang, Feng Liu, Jing Quan
Summary: A novel cuproptosis-related lncRNA signature was identified that could predict the prognosis and immune landscape of BLCA. This signature not only had a higher diagnostic efficiency compared to other clinical features, but also had a good performance in predicting the 1-year, 3-year, and 5-year overall survival rate in BLCA. Patients with a low risk score seemed to be associated with an inflamed tumor immune microenvironment and had a higher TMB level than those with a high risk score.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mingyi Yang, Haishi Zheng, Ke Xu, Qiling Yuan, Yirixaiti Aihaiti, Yongsong Cai, Peng Xu
Summary: This study identified CRLncs that can guide OS prognosis and the immune microenvironment, as well as drugs with potential efficacy for OS, providing a theoretical basis for OS survival research and clinical decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yefeng Shen, Deyu Li, Qiong Liang, Mengsi Yang, Youguang Pan, Hui Li
Summary: This study investigated the genomic alterations in lung adenocarcinoma samples and identified three distinct gene subsets. They also developed a CuFescore scoring scheme to predict patient sensitivity to immunotherapy and chemotherapeutic drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Physical
Kangning Wang, Mengran Qin, Chuantao Wang, Ting Yan, Yanzhong Zhen, Xiaolei Sun, Jianwei Wang, Feng Fu
Summary: The construction of composite materials is an effective strategy to solve the problems of poor conductivity, manganese dissolution, and volume expansion of manganese-based materials. Herein, a CeO2/MnOx@C hollow composite cathode derived from the self-assembly of Ce-Mn-MOFs was synthesized. The 1% CeO2/MnOx@C composite cathode exhibits a high reversible capacity and excellent cycling stability, with a remarkable reversible specific capacity of 130 mAh/g at a current density of 500 mA g(-1), 6.5 times more than the pure MnOx (20 mAh/g), and a capacity retention of 99.5% after 800 cycles. This study provides a new strategy for designing rare-earth composite electrodes to improve electrochemical performance.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yunhong He, Jianwei Wang, Shuping Wang, Kaxi Yu, Jun Zhou, Jinqiang Wang, Guping Tang, Zhen Gu, Hongzhen Bai
Summary: This study develops a nanomedicine inspired by mussel adhesive proteins, which exhibits tumor-targeted adhesion and penetration for enhanced photodynamic therapy and hypoxia-driven chemotherapy. The nanomedicine utilizes the recognition between the DOPA residues of mussel adhesive proteins and the PBA moieties of the prodrug to achieve tumor environment-responsive bioadhesion and penetration. It shows a combination antitumor effect by generating reactive oxygen species and aggravating tumor hypoxia.
Article
Chemistry, Physical
Lin Wang, Yuannan Lai, Hua Tian, Jianwei Wang, Wenjun Zhao, Yanyan Wang, Lingyu Li, Lixin Zhang
Summary: Polyaniline (PANI) was attached to the surface of O-V2CTx MXene through an electrostatic self-assembly process to form a three-dimensional hybrid composite structure. The surface of O-V2CTx MXene, with the emergence of vanadium-oxygen terminations, attracts PANI and undergoes in situ oxidation to transform C-V/V2+ to V3+ and V4+ species. The intercalation of PANI as spacing blocks between O-V2CTx nanosheets suppresses re-stacking and enhances Zn2+ diffusion processes and surface electrochemical activity. The PANI/O-V2CTx composites exhibit a reversible capacity of 267.7 mAh g-1 at 0.2 A g-1 and excellent cycling stability with a capacity retention of 91.8% after 2000 cycles at 5 A g-1. The in situ structural characterizations show the reversible redox transformation between V4+ and V5+ species on the surface of O-V2CTx MXene with the help of electrochemically active PANI. (c) 2023 Published by Elsevier B.V.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Mechanical
Kai Feng, Jianwei Wang, Hang Li, Yuanhui Wu, Peng Wang, Wenjun Li
Summary: In this paper, a novel porous tilting pad gas bearing (PTPGB) with hermetic squeeze film dampers based on multilayer diaphragm structure (MLD-HSFD) is proposed for oil-free turbomachinery. A dynamic model of MLD-HSFDs including the frequency dependence effect is presented by considering the compressibility of the damper fluid. An experimental test rig was assembled to measure the performance of MLD-HSFDs. The model predicts well the test data, including the frequency dependence of force coefficients. A comprehensive theoretical model of PTPGBs with MLD-HSFDs is proposed based on the implementation of the isothermal compressible Reynolds equation coupled to a flexible support and porous models. The effects of thickness of diaphragms thickness, bearing clearance, and supply pressure on bearing performance are discussed.
TRIBOLOGY TRANSACTIONS
(2023)
Article
Oncology
Miaorong Xu, Yuyan Zheng, Zhongchao Zuo, Qin Zhou, Qun Deng, Jianwei Wang, Da Wang
Summary: This case report presents a 20-year-old female with familial adenomatous polyposis (FAP) who initially presented with thyroid cancer and later developed colon cancer liver metastases. Genetic testing revealed a novel mutation in the APC gene. The mutation may contribute to the pathogenesis of the disease through beta-catenin accumulation, cell cycle microtubule dysregulation, and tumor suppressor inactivation.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yiqun Fan, Xiaoling Zhu, Chengcai Xu, Caiyou Ding, Jibo Hu, Qiang Hong, Jianwei Wang
Summary: The NECI Study is a multicenter, prospective, single-arm, phase II clinical trial to assess the efficacy and safety of neoadjuvant arterial embolisation chemotherapy combined with tislelizumab and systemic chemotherapy in locally advanced rectal cancer.
Article
Pharmacology & Pharmacy
Zhibao Zheng, Na Luan, Kai Tu, Feiyan Liu, Jianwei Wang, Jianguo Sun
Summary: PCDH7 expression in colorectal cancer cells is positively correlated with cell proliferation and drug resistance, while negatively correlated with cell migration and invasion. PCDH7 mediates drug resistance by inhibiting cell apoptosis through upregulating Mcl-1 expression and activating the Wnt signaling pathway. The Mcl-1 inhibitor S63845 can attenuate the anti-apoptotic effect of PCDH7 and sensitizes PCDH7-overexpressing colorectal cancer cells to ABT-263.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Jian-Wei Wang, Xiao-Bo Yuan, Hong-Fang Chen
Summary: In this case report, a unique case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome initially misdiagnosed as autoimmune encephalitis was ultimately confirmed as MELAS with the mitochondrial DNA 3243A>G mutation.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Chemistry, Physical
Yuqi Tang, Haiyuan Chen, Jianwei Wang, Xiaobin Niu
Summary: Machine learning is used to efficiently predict important physical quantities of materials, such as band gaps, for doped semiconductors. By combining density functional theory calculations and ML predictive models, the band gaps are successfully obtained, including cases of extremely low-concentration doping. The ML models are validated and the method accelerates the prediction of physical properties of semiconductors.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Fangqian Wang, Yuxiao Ye, Zengjie Zhang, Wangsiyuan Teng, Hangxiang Sun, Xupeng Chai, Xingzhi Zhou, Jiayu Chen, Haochen Mou, Yinwang Eloy, Xiaoqiang Jin, Liang Chen, Zhenxuan Shao, Yan Wu, Yue Shen, An Liu, Peng Lin, Jianwei Wang, Xiaohua Yu, Zhaoming Ye
Summary: The PDGF-BB/PDGFR-beta pathway has been controversial in its role in osteogenesis. This study demonstrates that temporal inhibition of the PDGF-BB/PDGFR-beta pathway can promote osteogenesis and improve bone regeneration by shifting the proliferation/differentiation balance of skeletal stem and progenitor cells. Inhibition of PDGFR-beta enhances differentiation towards osteoblasts and accelerates bone formation, even in the absence of scaffold implantation. Mechanistically, blocking PDGFR-beta leads to upregulation of osteogenesis-related products of Smad, inducing osteogenesis. This study provides new insights and therapeutic methods in the field of bone repair.
Article
Chemistry, Physical
Yi Luo, Haiyuan Chen, Jianwei Wang, Xiaobin Niu
Summary: The authors propose a machine-learning-assisted approach to discover boron-doped graphene with a high work function (WF). A Crystal Graph Convolutional Neural Network is developed to efficiently predict the WF for all possible configurations. The B5C27 structure is found to have the highest WF in the entire space, and it is linearly related to the adsorption energy of alkali metals. Additionally, B5C27 shows a higher theoretical specific capacity as an anode for Li/Na/K-ion batteries. This work provides an effective way to locate high-WF structures in heteroatom-doped systems and may accelerate the screening of promising adsorbents for alkali metals.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Oncology
Na Luan, Jiaojiao Wang, Biao Sheng, Qin Zhou, Xun Ye, Xiaoling Zhu, Jianguo Sun, Zhe Tang, Jianwei Wang
Summary: Recent studies have found that changes in the tumor microenvironment can affect the expression of noncoding small RNA tRNA-derived fragments (tRFs), leading to altered tumor metastasis. However, the mechanism by which tRFs mediate tumor metastasis and their relationship with lncRNAs and alternative splicing regulation by noncoding RNAs remain unknown. This study investigated the mechanism of tRF-mediated SMC1A alternative splicing and its regulation of colon cancer metastasis from cellular, molecular, animal, and clinical perspectives. The findings revealed the inhibitory role of tRF-20M0NK5Y93 in colon cancer metastasis and the correlation between tRFs, MALAT-1, and SRSF2 in transcriptional sequencing and bioinformatics analysis. The study also uncovered the interaction between different noncoding RNAs in alternative splicing, suggesting a potential therapeutic target.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Surgery
JianWei Wang, Xun Ye, Qin Zhou, ChengCai Xu, YiQun Fan, Na Luan, XiaoLing Zhu
Summary: This study introduced a personal technique, called parachute-like intussuscept pull-through anastomosis, to address the issues of anal functional disorder and anastomosis-related complications in low rectal cancer surgery. The results showed that this method can relatively reduce surgical complications, minimize the impact on anal function, and obviate the need for colostomy creation.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jianwei Wang, Wenhui Wang, Huan Wang, Wenlin Zhang, Yanzhong Zhen, Feng Fu, Bin Xu
Summary: Aqueous alkaline rechargeable batteries have great potential in energy storage due to their low cost, safety, and high ionic conductivity. However, the performance is often limited by electrode materials. In this study, a CoNiMn-LDH cathode and a Bi2O3 anode with specific structures were prepared using MOFs as templates. The resulting battery showed higher capacity, faster charge transport dynamics, and cycling stability. This research provides valuable insights for the design and preparation of advanced electrode materials for full batteries.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Materials Science, Multidisciplinary
Lisha Xie, Xuhong Zhao, Jianwei Wang, Jun Li, Chang Liu, Shurong Wang, Qinye Bao, Mengjin Yang, Xiaobin Niu, Feng Hao, Ziyi Ge
Summary: Functional additives are used to improve the performance and stability of perovskite solar cells (PSCs) in this study. Theoretical calculations and experimental measurements show that the additives can reduce the voltage deficit and improve the charge transfer in the perovskite films. Furthermore, the additives effectively suppress the formation of defects and inhibit the trap-assisted recombination at grain boundaries. By optimizing the use of additives, more stable and efficient PSCs can be achieved.
