Journal
FRONTIERS IN ONCOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.865917
Keywords
hepatocellular carcinoma; M6A; lncRNA; prognostic signature; AC012073; 1
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Funding
- National Natural Science Foundation of China [81960119]
- Scientific Research Project of Guangxi Health Commission [z2015196]
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This study identified potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC) and found that a specific lncRNA (AC012073.1) functions as an oncogenic factor in affecting HCC prognosis.
N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, in vitro experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis.
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