Article
Medicine, Research & Experimental
Guofang Lu, Siyuan Tian, Yi Sun, Jiaqiang Dong, Na Wang, Jiaoxia Zeng, Yongzhan Nie, Kaichun Wu, Ying Han, Bin Feng, Yulong Shang
Summary: Inflammatory stimuli in the tumor microenvironment play vital roles in cancer progression, with the mechanism of inflammation-induced cancer metastasis in gastric cancer still poorly understood. NEK9 directly regulates cell motility and RhoA activation in gastric cancer by phosphorylating ARHGEF2. The IL-6-mediated suppression of miR-520f-3p leads to an increase in NEK9, GP130, and STAT3 levels, contributing to reduced overall survival of GC patients. Targeting the IL-6-STAT3-NEK9 pathway may offer a new strategy for treating gastric cancer.
Article
Cell Biology
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu
Summary: Ciclopirox (CPX), an antifungal drug, has shown promising potential as a treatment for gastric cancer (GC). It inhibits GC growth through suppressing proliferation and stimulating autophagic cell death. Mechanistically, CPX regulates the phosphorylation of STAT3 at Tyr705 and Ser727 residues to regulate cell growth and autophagic cell death.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Jing Hu, Francisco J. Sanchez-Rivera, Zhenghan Wang, Gabriela N. Johnson, Yu-jui Ho, Karuna Ganesh, Shigeaki Umeda, Siting Gan, Adriana M. Mujal, Rebecca B. Delconte, Jessica P. Hampton, Huiyong Zhao, Sanjay Kottapalli, Elisa de Stanchina, Christine A. Iacobuzio-Donahue, Dana Pe'er, Scott W. Lowe, Joseph C. Sun, Joan Massague
Summary: Metastasis often occurs when cancer cells that are dormant after primary tumor treatment become active again. The stimulator of interferon genes (STING) pathway has been identified as a suppressor of metastatic outbreak and a potential therapeutic target to prevent disease relapse. By understanding the determinants of immune reactivity during exit from dormancy, researchers have found that STING activity increases in metastatic progenitors that re-enter the cell cycle and can be dampened by methylation or chromatin repression. Activation of STING function in cancer cells derived from spontaneous metastases eliminates dormant metastasis and prevents spontaneous outbreaks.
Article
Pharmacology & Pharmacy
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu
Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sanda Win, Robert W. M. Min, Jun Zhang, Gary Kanel, Brad Wanken, Yibu Chen, Meng Li, Ying Wang, Ayako Suzuki, Filbert W. M. Aung, Susan F. Murray, Mariam Aghajan, Tin A. Than, Neil Kaplowitz
Summary: The study found that hepatic SAB expression increased progressively in mice fed a high-fat, high-calorie, high-fructose diet, affecting systemic energy expenditure and body fat levels by controlling the JNK/ATF2 activation loop. Deletion or silencing of SAB inhibited the development of steatohepatitis, fibrosis, and metabolic abnormalities, suggesting that induction of SAB in hepatocytes plays a critical role in the interplay between liver and systemic metabolic consequences of overfeeding. Targeted GalNAc-Sab-ASO treatment in hepatocytes reversed steatohepatitis and fibrosis in established NASH.
Article
Cell Biology
Zhuo Bao, Ang Li, Xuebo Lu, Zitong Wang, Yin Yu, Wenjie Wu, Lili Zhao, Bo Li, Xiangyu Wu, Kyle Vaughn Laster, Chengjuan Zhang, Yanan Jiang, Zigang Dong, Kangdong Liu
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly prevalent malignant tumor, and current treatment strategies have limited efficacy. This study found that oxethazaine can inhibit ESCC proliferation and metastasis by targeting AURKA.
CELL DEATH & DISEASE
(2022)
Article
Pharmacology & Pharmacy
Xinglong Ma, Wenyuan Xu, Xinmeng Jin, Haoran Mu, Zhuoying Wang, Yingqi Hua, Zhengdong Cai, Tao Zhang
Summary: Osteosarcoma, the most common primary bone malignancy in children and adolescents, has a high mortality rate due to its rapid growth and metastatic potential. The JAK2/STAT3 signaling pathway, critical for osteosarcoma occurrence and development, is a potential target for treatment. Telocinobufagin (TCB), a natural product isolated from toad cake, was identified as a potent candidate with anti-osteosarcoma effects. TCB inhibited osteosarcoma cell growth, migration, invasion, and induced cancer cell apoptosis by specifically inhibiting the JAK2/STAT3 signaling pathway. In an osteosarcoma xenograft animal model, TCB significantly suppressed tumor growth and metastasis. Moreover, TCB showed strong inhibitory effects in other cancer types such as lung cancer, liver cancer, colon cancer, breast cancer, and gastric cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Roberto Coppo, Francesca Orso, Federico Virga, Alberto Dalmasso, Desiree Baruffaldi, Lei Nie, Fabiana Clapero, Daniela Dettori, Lorena Quirico, Elena Grassi, Paola Defilippi, Paolo Provero, Donatella Valdembri, Guido Serini, Mehran M. Sadeghi, Massimiliano Mazzone, Daniela Taverna
Summary: ESDN plays a critical role in melanoma progression by regulating the expression of E-selectin in endothelial cells, affecting melanoma cell adhesion, extravasation, and metastasis formation. The study proposes a protective role for ESDN in melanoma spread and highlights its therapeutic potential.
Article
Biochemistry & Molecular Biology
Hongtao Hu, Haoyang Bai, Lili Huang, Bo Yang, Huajun Zhao
Summary: In this study, Eupalinolide J (EJ) was identified as a potential anti-cancer metastatic agent by target prediction and molecular docking technique screening. EJ exhibited a good inhibitory effect on cancer cell metastasis both in vitro and in vivo, and downregulated the expression of the metastasis-related genes MMP-2 and MMP-9 by promoting STAT3 ubiquitin-dependent degradation. Therefore, EJ could be applied in cancer therapy as a STAT3 degradation agent to inhibit cancer cell metastasis.
Article
Medicine, Research & Experimental
Tao Pan, Zhenjia Yu, Zhijian Jin, Xiongyan Wu, Airong Wu, Junyi Hou, Xinyu Chang, Zhiyuan Fan, Jianfang Li, Beiqin Yu, Fangyuan Li, Chao Yan, Zhongyin Yang, Zhenggang Zhu, Bingya Liu, Liping Su
Summary: The study revealed that lnc-CTSLP4 is significantly downregulated in gastric cancer tumor tissues, and by interacting with proteins and recruiting E3 ubiquitin ligase ZFP91, it inhibits the metastatic potential of GC cells.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, Research & Experimental
Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Y. Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy Babwah, Moshmi Bhattacharya
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease associated with obesity, diabetes, and metabolic syndrome. Activation of the kisspeptin 1 receptor (KISS1R) signaling pathway has therapeutic effects in treating NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Eui-Kyu Noh, Hye Jin Seo, Yoo Jin Lee, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
Summary: Radotinib has been shown to induce apoptosis and inhibit cell proliferation in multiple myeloma cells by suppressing the activity and expression of STAT3 and JAK2 proteins. It also inhibits the growth of MM cells and related signaling proteins, making it a potential candidate for MM treatment.
Article
Cell Biology
Minghao Yang, Yuzhu Zhang, Guangping Liu, Ziqian Zhao, Jigang Li, Le Yang, Kui Liu, Wei Hu, Yunwei Lou, Jie Jiang, Qing Liu, Peiqing Zhao
Summary: This study found that TIPE1 expression is decreased in osteosarcoma tissues and is negatively related to tumor stage and size. TIPE1 inhibits osteosarcoma carcinogenesis and metastasis by inhibiting PRMT1-mediated STAT3 arginine methylation. These findings provide a potential molecular target for the treatment of osteosarcoma.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Jia Wang, Xue Dong, Dandan Li, Zhiyao Fang, Xianyao Wan, Jing Liu
Summary: This study found that fucoxanthin can inhibit lymphangiogenesis and lymph node metastasis in gastric cancer by regulating Ran expression and the importin beta/NF-kappa B/VEGF-C nuclear transport signaling pathway. These novel findings provide the basis for the research and development of novel treatments using traditional Chinese medicine in the treatment of lymph node metastasis, which has important theoretical significance and clinical value.
Article
Oncology
Debarati Mukherjee, Rebecca A. Previs, Corinne Haines, Muthana Al Abo, Patrick K. Juras, Kyle C. Strickland, Binita Chakraborty, Sandeep Artham, Regina S. Whitaker, Katherine Hebert, Jake Fontenot, Steven R. Patierno, Jennifer A. Freedman, Frank H. Lau, Matthew E. Burow, Ching-Yi Chang, Donald P. McDonnell
Summary: Triple-negative breast cancers (TNBC) and high-grade serous ovarian cancer (HGSOC) are both aggressive and difficult to treat. This study found that the serine/threonine kinase CaMKK2 plays a significant role in promoting metastasis in these cancers, and inhibiting CaMKK2 can effectively block metastatic progression. The mechanism involves the CaMKK2- PDE1A-PKG1-VASP signaling pathway, which regulates actin cytoskeleton dynamics and cell motility. This research highlights CaMKK2 as a potential therapeutic target for restricting tumor invasiveness in TNBC and HGSOC patients.