Circulating Exhausted PD-1+CD39+ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade

Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer

(2022) Ilaria Grazia Zizzari et al.   CLINICAL CANCER RESEARCH

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

(2022) Ricardo A. Chaurio et al.   IMMUNITY

Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function

(2022) Joshua R. Veatch et al.   CANCER CELL

Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers

(2022) Chunhong Zheng et al.   CANCER CELL

CD137+ T-Cells: Protagonists of the Immunotherapy Revolution

(2021) Alessio Ugolini et al.   Cancers

The Next Decade of Immune Checkpoint Therapy

(2021) Padmanee Sharma et al.   Cancer Discovery

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

(2021) Christiane S. Eberhardt et al.   NATURE

PD-1+CXCR5−CD4+ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma

(2021) Jiang-Ping Li et al.   Journal for ImmunoTherapy of Cancer

Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade

(2021) Natalija Budimir et al.   Cancer Immunology Research

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

(2020) Camille-Charlotte Balança et al.   Cancer Immunology Research

CD39 identifies the CD4+ tumor-specific T cell population in human cancer

(2020) Kim E Kortekaas et al.   Cancer Immunology Research

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells

(2020) Camille-Charlotte Balança et al.   JCI Insight

Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

(2019) Ivan Perrot et al.   Cell Reports

Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?

(2019) P Hofman et al.   ANNALS OF ONCOLOGY

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals

(2019) Maria M. Klicznik et al.   Science Immunology

MHC-II neoantigens shape tumour immunity and response to immunotherapy

(2019) Elise Alspach et al.   NATURE

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Resident memory T cells, critical components in tumor immunology

(2018) Fathia Mami-Chouaib et al.   Journal for ImmunoTherapy of Cancer

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictors of responses to immune checkpoint blockade in advanced melanoma

(2017) N. Jacquelot et al.   Nature Communications

CD8+CD103+Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients

(2015) Fayçal Djenidi et al.   JOURNAL OF IMMUNOLOGY

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

CD4+ T Effectors Specific for the Tumor Antigen NY-ESO-1 Are Highly Enriched at Ovarian Cancer Sites and Coexist with, but Are Distinct from, Tumor-Associated Treg

(2013) M. Ayyoub et al.   Cancer Immunology Research

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)

(2010) Tyler R Simpson et al.   CURRENT OPINION IN IMMUNOLOGY