Biodistribution of a Mitochondrial Metabolic Tracer, [18F]F-AraG, in Healthy Volunteers

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

(2021) Jiali Yu et al.   NATURE MEDICINE

Longitudinal imaging of T-cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI

(2021) Caroline Guglielmetti et al.   JOURNAL OF NUCLEAR MEDICINE

Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance

(2020) Bettina Stolp et al.   Science Immunology

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

(2020) Santosha A. Vardhana et al.   NATURE IMMUNOLOGY

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

(2020) Tamara Rothenburger et al.   Communications Biology

Imaging of activated T cells as an early predictor of immune response to anti-PD-1 therapy

(2019) Jelena Levi et al.   CANCER RESEARCH

CD103+Tumor-Resident CD8+T Cells Are Associated with Improved Survival in Immunotherapy-Naïve Melanoma Patients and Expand Significantly During Anti–PD-1 Treatment

(2018) Jarem Edwards et al.   CLINICAL CANCER RESEARCH

Mitochondrial activity in T cells

(2018) Gabriela Desdín-Micó et al.   MITOCHONDRION

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

(2018) Lauren E. Holz et al.   Cell Reports

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

Tissue-Resident Lymphocytes in the Kidney

(2017) Jan-Eric Turner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis

(2017) Benjamin L. Franc et al.   Molecular Imaging

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Human Biodistribution and Radiation Dosimetry of 18 F-Clofarabine, a PET Probe Targeting the Deoxyribonucleoside Salvage Pathway

(2016) Martin J. Barrio et al.   JOURNAL OF NUCLEAR MEDICINE

Mitochondrial purine and pyrimidine metabolism and beyond

(2016) Liya Wang   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

(2016) Woosuk Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation dosimetry of 18F-FDG PET/CT: incorporating exam-specific parameters in dose estimates

(2016) Brian Quinn et al.   BMC MEDICAL IMAGING

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase

(2015) Elisa Franzolin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Salivary Gland Acts as a Sink for Tissue-Resident Memory CD8 + T Cells, Facilitating Protection from Local Cytomegalovirus Infection

(2015) Jenny Tosca Thom et al.   Cell Reports

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway

(2010) Johannes Schwarzenberg et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Activation of guanine-β-d-arabinofuranoside and deoxyguanosine to triphosphates by a common pathway blocks T lymphoblasts at different checkpoints

(2010) Luigi Leanza et al.   EXPERIMENTAL CELL RESEARCH

Molecular mechanisms of nucleoside recycling in the brain

(2010) Piero Luigi Ipata et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthesis of 2′-Deoxy-2′-[18F]Fluoro-9-β-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET

(2010) Mohammad Namavari et al.   MOLECULAR IMAGING AND BIOLOGY

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology