Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients

Increased metformin dosage suppresses pro-inflammatory cytokine levels in systemic circulation and might contribute to its beneficial effects

(2021) Benjamin Amoani et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Does metformin modulate mitochondrial dynamics and function in type 2 diabetic patients?

(2021) Aranzazu Martinez de Marañón et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study

(2020) Shipra Bhansali et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

(2020) Alexis Diaz-Vegas et al.   ENDOCRINE REVIEWS

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

(2020) Nadezda Apostolova et al.   Redox Biology

Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025

(2020) Xiling Lin et al.   Scientific Reports

Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis

(2019) Mark V Pinti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action

(2019) Shipra Bhansali et al.   Annals of the New York Academy of Sciences

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

(2019) Marc Foretz et al.   Nature Reviews Endocrinology

Trends in incidence of total or type 2 diabetes: systematic review

(2019) Dianna J Magliano et al.   BMJ-British Medical Journal

Autophagic flux defect in diabetic kidney disease results in megamitochondria formation in podocytes

(2019) Chang-Yun Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Does Metformin Modulate Endoplasmic Reticulum Stress and Autophagy in Type 2 Diabetic Peripheral Blood Mononuclear Cells?

(2018) Noelia Diaz-Morales et al.   ANTIOXIDANTS & REDOX SIGNALING

Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy

(2018) Mariël F. van Stee et al.   Cardiovascular Diabetology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Mitochondrial quality control in the diabetic heart

(2016) Qiangrong Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy

(2015) Anna Czajka et al.   EBioMedicine

Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart

(2014) Tara L. Croston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions

(2014) Sanna-Mari Aatsinki et al.   BRITISH JOURNAL OF PHARMACOLOGY

Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3)

(2014) John J. Lemasters   Redox Biology

Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction

(2012) Zuheng Ma et al.   Islets

Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice

(2009) Takashi Yokota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY