Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.949033
Keywords
bile acids; microbial metabolites; immunity; intestinal inflammation; host-microbiota interactions
Categories
Funding
- National Science Centre (SONATA 16) [2021/41/B/NZ6/02219]
- OPUS 21
- [2020/39/D/NZ6/02146]
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Host-microbiota interactions are bidirectional, and bile acids play a significant role in shaping the composition and function of the microbiota, as well as modulating host immunity. Understanding the mechanisms behind this unique dialogue is important for treating intestinal inflammation.
Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation.
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