Article
Oncology
Dashuai Yang, Fangrui Zhao, Yang Su, Yu Zhou, Jie Shen, Bin Yu, Kailiang Zhao, Youming Ding
Summary: A prognostic model for hepatocellular carcinoma based on NK cell marker genes was constructed using single cell sequencing and transcriptome data analysis. The model identified eight genes with prognostic value, and was validated using independent data sets. The low-risk group showed higher immune cell infiltration and function, and was more responsive to immunotherapy. Additionally, the model predicted differences in chemotherapeutic response between the high and low-risk groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Peng Song, Wenbin Li, Xiaoxuan Wu, Zhirong Qian, Jianming Ying, Shugeng Gao, Jie He
Summary: This study explored the expression profile of B cell marker genes in lung adenocarcinoma (LUAD) and constructed a prognostic signature based on these genes. The signature effectively predicted patients' survival and served as a predictor for immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Zi-Tao Liu, Jun-Ting Shen, Yu-Jie Lei, Yun-Chao Huang, Guang-Qiang Zhao, Cheng-Hong Zheng, Xi Wang, Yu-Tian Wang, Long Chen, Zi-Xuan Li, Shou-Zhuo Li, Jun Liao, Ting-Dong Yu
Summary: In this study, molecular subtypes based on LICMGs were identified in lung adenocarcinoma patients, which provided a promising strategy for predicting patient prognosis, biological characteristics, and immune microenvironment features. Furthermore, the molecular subtypes helped identify the patients most likely to benefit from immunotherapy and chemotherapy.
Article
Immunology
Xuezhong Shi, Ani Dong, Xiaocan Jia, Guowei Zheng, Nana Wang, Yuping Wang, Chaojun Yang, Jie Lu, Yongli Yang
Summary: In this study, researchers identified 72 T-cell marker genes through a comprehensive analysis of single-cell RNA sequencing data and constructed a 5-gene prognostic signature. Additionally, they found that the high-risk group exhibited higher levels of immune score, stromal score, and immune cell infiltration, as well as sensitivity to four chemotherapeutic drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Peiru Wei, Mingyou Dong, Yin Bi, Saiqiong Chen, Weiyu Huang, Ting Li, Bo Liu, Xiaoqian Fu, Yihua Yang
Summary: The study identified 1293 macrophage marker genes through single-cell RNA sequencing analysis, and identified seven core genes closely related to recurrent miscarriage (RM) using various algorithms. A nomogram constructed from the expression levels of these genes showed high diagnostic value for RM, suggesting potential targets for preventative treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhimou Cai, Bingjie Tang, Lin Chen, Wenbin Lei
Summary: This study identified a prognostic mast cell gene signature (MCS) using single-cell RNA sequencing analysis to assess the prognosis and immunotherapy response of patients with head and neck squamous cell carcinoma (HNSCC). The MCS effectively distinguished survival outcomes and could be used as a predictive indicator for immunotherapy response and decision-making.
Article
Oncology
Xuezhong Shi, Ani Dong, Yongli Yang, Guowei Zheng, Nana Wang, Chaojun Yang, Yuping Wang, Jie Lu, Xiaocan Jia
Summary: We developed a prognostic signature based on T-cell marker genes and found that the low-risk group had better immunotherapy response and prognosis in bladder cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Haijun Tang, Shangyu Liu, Xiaoting Luo, Yu Sun, Xiangde Li, Kai Luo, Shijie Liao, Feicui Li, Jiming Liang, Xinli Zhan, Qingjun Wei, Yun Liu, Maolin He
Summary: This study developed a new molecular signature based on TILs marker genes, which is very effective in predicting OS prognosis and immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wei Jiang, Jiameng Xu, Zirui Liao, Guangbin Li, Chengpeng Zhang, Yu Feng
Summary: Through analysis of the GSE68465 dataset, we identified 10 LUAC-specific CCRGs and constructed a model. Based on this model, LUAC patients were divided into high- and low-risk groups and the validity was confirmed. Data from CPTAC, HPA, and IHC supported significant dysregulation of these CCRGs in LUAC tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhanghao Huang, Muqi Shi, Hao Zhou, Jinjie Wang, Hai-Jian Zhang, Jia-Hai Shi
Summary: The study identified signature genes related to stem cells in LUAD that can effectively predict patient prognosis, divide patients into high-risk and low-risk groups, and evaluate clinical efficacy and prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Hao Zhang, Zeyu Wang, Ziyu Dai, Wantao Wu, Hui Cao, Shuyu Li, Nan Zhang, Quan Cheng
Summary: In this study, the infiltration pattern of 65 immune cells was collected and evaluated to construct the Immune Cell Pair (ICP) score, which showed a robust reliability and efficacy in predicting the survival of patients with gliomas, in pan-cancer samples, and six independent cancer types. The ICP score was also correlated with the genomic alteration features in gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Rui Zhou, Zhuowei Gao, Yongle Ju
Summary: This study aimed to determine the prognostic value of immune genes in patients with colon adenocarcinoma (COAD) and establish an immune-related gene signature. Through analysis of different databases, immune-related genes were identified and a gene network was constructed. A risk model was developed based on patient data to differentiate high-risk and low-risk groups. The results showed that this immune-related gene signature plays an important role in treatment guidance, prognosis assessment, and potential clinical applications.
BMC BIOINFORMATICS
(2022)
Article
Endocrinology & Metabolism
Pengxiang Tian, Zhiming Zhao, Yanli Fan, Na Cui, Baojun Shi, Guimin Hao
Summary: This study investigated the effects of stress on male reproductive function by observing changes in the testes of rats exposed to stress. It found that chronic stress can lead to pathological changes in the testes, decreased expression of key marker genes related to spermatogenesis, and alterations in the population of spermatogenic cells, which may contribute to male reproductive dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chia-Ching Chang, Min-Shu Hsieh, Mong-Wei Lin, Yi-Hsuan Lee, Yi-Jing Hsiao, Kang-Yi Su, Te-Jen Su, Sung-Liang Yu, Jin-Shing Chen
Summary: This study established a novel three-gene prognostic signature for predicting the clinical outcomes of lung adenocarcinoma by comparing differences in gene expression profiles between low- and high-grade adenocarcinomas.
Article
Biochemical Research Methods
Xu Chen, Chuang Peng, Yu Chen, Bai Ding, Sulai Liu, Yinghui Song, Yuhang Li, Bo Sun, Ranzhiqiang Yang
Summary: This study identified 181 T-cell markers through single-cell RNA sequencing and developed a 13-gene based prognostic signature (TRPS) for HCC patients. The TRPS could effectively predict the prognosis of HCC and serve as a predictor for immunotherapy.
BMC BIOINFORMATICS
(2023)