Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.913028
Keywords
neutrophils; neutrophil extracellular traps; Candida albicans; virulence factors; innate immunity
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Funding
- National Natural Science Foundation of China [82173867]
- Shanghai Science and Technology Innovation Action Plan
- International Science and Technology Cooperation Project [21430713000]
- Shanghai Science and Technology Support Project in the Field of Biomedicine Project [19431901300]
- Shanghai Pujiang Program [21PJD0081]
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Candida albicans activates neutrophils to release NETs as a defense mechanism, while also developing specific strategies to respond to the attack by NETs.
Candida albicans is the most common pathogen causing clinical Candida infections. Neutrophils are a key member of the host innate immunity that plays an essential role in clearing invading C. albicans. In addition to the well-known defensive approaches such as phagocytosis, degranulation, and reactive oxygen species production, the formation of neutrophil extracellular traps (NETs) has also become an important way for neutrophils to defend against various pathogens. C. albicans has been reported to be capable of activating neutrophils to release NETs that subsequently kill fungi. The induction of NETs is affected by both the morphology and virulence factors of C. albicans, which also develops specific strategies to respond to the attack by NETs. Our review specifically focuses on the mechanisms by which C. albicans triggers NET formation and their subsequent interactions, which might provide meaningful insight into the innate immunity against C. albicans infection.
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