Review
Immunology
Waller-Pulido Alejandra, Jimenez-Perez Miriam Irene, Gonzalez-Sanchez Fabio Antonio, Rojo-Gutierrez Rocio Patricia, Torres-Anguiano Elizabeth, Aleman-Aguilar Juan Pablo, Garcia-Varela Rebeca
Summary: Monoclonal antibodies (mAbs) have been widely used in immunotherapies against various diseases and have potential in immunization. They play a key role in recognizing and targeting specific antigens. Different types of mAbs are discussed, and common techniques such as hybridomas or phage display are used for their production. Specialized downstream processes are employed to achieve desired yield, isolation, and product quality. Novel perspectives in these protocols can lead to improved high-scale production of mAbs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Hanae Miyazawa, Taizo Wada
Summary: This review discusses recent findings in inflammatory diseases associated with chronic excess of serum IL-18 and describes the clinical and therapeutic relevance of understanding the pathology of this group of diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Helen Haixia Wu, Kerry-Leigh Ralph, Eliud Sepuldeva, Gale Hansen, Hua Li, Zhong-Fu Huang, Dongmei Liu, Michael Dziegelewski, Jennifer Ahlberg, Lee Frego, Steve Fogal, Susan van Tongeren, Christine Grimaldi, Tobias Litzenberger, David Presky, Sanjaya Singh, Scott Brodeur, Rachel Kroe-Barrett
Summary: The study presents a novel antibody BI 655064 targeting the CD40-CD40L pathway, which effectively neutralizes the pathogenesis of related diseases and has high therapeutic potential.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Clinical Neurology
Jason C. Ray, Penelope Allen, Ann Bacsi, Julian J. Bosco, Luke Chen, Michael Eller, Hock Kua, Lyndell L. Lim, Manjit S. Matharu, Mastura Monif, Martin Ruttledge, Richard J. Stark, Elspeth J. Hutton
Summary: This case series offers insights into the potential molecular mechanisms and side effects of CGRP antagonism in migraine, emphasizing the need for clinical vigilance in patient care moving forward.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Immunology
S. P. Deo-Gracias Berry, Camille Dossou, Ali Kashif, Niusha Sharifinejad, Gholamreza Azizi, Haleh Hamedifar, Araz Sabzvari, Zeineb Zian
Summary: This review highlights the role of IL-17 in chronic inflammation occurring in allergy, malignancy, and autoimmune diseases, and discusses the potential therapeutic approach of targeting IL-17 and/or IL-17R using monoclonal antibodies (mAbs).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Li Jiao, Shougang Guo
Summary: This review summarizes the research progress and prospects of anti-interleukin-6 (IL-6) therapy in the treatment of central nervous system inflammatory demyelinating diseases (IDDs).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Joshua Zarbl, Ekaterina Eimer, Camilla Gigg, Gerlinde Bendzuck, Marianne Korinth, Corinna Elling-Audersch, Arnd Kleyer, David Simon, Sebastian Boeltz, Martin Krusche, Johanna Mucke, Felix Muehlensiepen, Nicolas Vuillerme, Gerhard Kroenke, Georg Schett, Johannes Knitza
Summary: The remote self-collection of capillary blood using upper arm-based devices for analysis of autoantibodies and CRP in patients with autoimmune rheumatic diseases is feasible, accurate, and well accepted among patients.
Review
Immunology
Pamir Ataguenduez, Goekhan Keser, Mehmet Soy
Summary: New variants of SARS-CoV-2 have raised concerns about the spread of COVID-19, particularly among patients with autoimmune/autoinflammatory rheumatic diseases (AIIRD). The timing of COVID-19 vaccination in AIIRD patients using Interleukin-1 (IL-1) blockers is still a topic of debate.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gaurav B. Nigam, Jimmy K. Limdi
Summary: The aim of IBD treatment is to control symptoms and suppress gut inflammation, with IL12/23 inhibitors and IL-23 inhibitors showing promise. Currently, Ustekinumab is approved for managing IBD patients, but there is still controversy regarding treatment selection and positioning.
BRITISH MEDICAL BULLETIN
(2021)
Article
Chemistry, Medicinal
Matthijs David Linssen, Wouter Tjerk Rudolph Hooghiemstra, Annelies Jorritsma-Smit, Derk Pieter Allersma, Gerard Dijkstra, Wouter Bastiaan Nagengast
Summary: In this study, monoclonal antibodies conjugated with different fluorescent markers were evaluated for their feasibility as clinical tracers for IBD patients. Out of 12 potential tracer candidates, 5 were considered feasible for further development, while others showed limitations in terms of aggregation, brightness reduction, and binding to targets. Further optimization may render some of the unfeasible candidates suitable for development.
Article
Immunology
Longxian Lv, Huiyong Jiang, Xiaoxiao Chen, Qiangqiang Wang, Kaicen Wang, Jianzhong Ye, Yating Li, Daiqiong Fang, Yingfeng Lu, Liya Yang, Silan Gu, Jianing Chen, Hongyan Diao, Ren Yan, Lanjuan Li
Summary: The study revealed significant alterations in the salivary microbiota of patients with primary biliary cholangitis (PBC), which may represent a contributing factor to oral inflammation and worsening liver function.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Junjie Gu, Chongying Su, Fei Huang, Yuwei Zhao, Jing Li
Summary: This article discusses the roles of circRNAs in immune-related diseases, including their expression profile analysis, potential biomarker research, impact on phenotypes, and applications and prospects in therapeutic target seeking.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Amber Papillion, Andre Ballesteros-Tato
Summary: Novel immunotherapies such as subcutaneous low-dose r-IL2 have shown potent immunosuppressive effects in autoimmune patients, particularly on Treg cells. Additionally, rIL-2 can directly inhibit other immune cells, potentially leading to a more efficient inhibition of auto-antibody production in autoimmune patients when combined with other cytokine-based therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryan J. Malonis, James T. Earnest, Arthur S. Kim, Matthew Angeliadis, Frederick W. Holtsberg, M. Javad Aman, Rohit K. Jangra, Kartik Chandran, Johanna P. Daily, Michael S. Diamond, Margaret Kielian, Jonathan R. Lai
Summary: This study isolated and characterized MAYV-reactive human monoclonal antibodies from a CHIKV-convalescent donor, revealing five mAbs that can potently neutralize multiple alphaviruses. Two of these broadly neutralizing mAbs provided protection against musculoskeletal disease induced by CHIKV and MAYV in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biology
Xinxin Chi, Miaozhen Huang, Hailin Tu, Bin Zhang, Xin Lin, Huji Xu, Chen Dong, Xiaoyu Hu
Summary: Except for a few cases caused by single gene mutations, the majority of autoimmune diseases are influenced by both environmental and genetic factors. Despite progress in understanding certain effector cells and molecules associated with inflammation and tissue damage, the exact cause of common autoimmune disorders remains unknown. Population genetics approaches have contributed greatly to our knowledge of genetic susceptibility to autoimmunity, allowing for a comprehensive re-examination of genes and pathways. This review aims to discuss the etiology and pathogenesis of common autoimmune disorders from a human genetics perspective, covering innate immunity, adaptive immunity, and inflammatory cell death processes. By exploring new molecules and pathways, we hope to broaden our understanding of autoimmunity beyond the current limited therapeutic targets.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Immunology
S. P. Deo-Gracias Berry, Camille Dossou, Ali Kashif, Niusha Sharifinejad, Gholamreza Azizi, Haleh Hamedifar, Araz Sabzvari, Zeineb Zian
Summary: This review highlights the role of IL-17 in chronic inflammation occurring in allergy, malignancy, and autoimmune diseases, and discusses the potential therapeutic approach of targeting IL-17 and/or IL-17R using monoclonal antibodies (mAbs).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Asena Pinar Sefer, Hassan Abolhassani, Franziska Ober, Basak Kayaoglu, Sevgi Bilgic Eltan, Altan Kara, Baran Erman, Naz Surucu Yilmaz, Cigdem Aydogmus, Sezin Aydemir, Louis-Marie Charbonnier, Burcu Kolukisa, Gholamreza Azizi, Samaneh Delavari, Tooba Momen, Simuzar Aliyeva, Yasemin Kendir Demirkol, Saban Tekin, Ayca Kiykim, Omer Faruk Baser, Haluk Cokugras, Mayda Gursel, Elif Karakoc-Aydiner, Ahmet Ozen, Daniel Krappmann, Talal A. Chatila, Nima Rezaei, Safa Baris
Summary: This study analyzed the clinical and immunological features of MALT1 deficiency and found that the main characteristics of the disease are recurrent infections, eczema, chronic diarrhea, and failure to thrive. Most patients had normal T and NK cells, while B cells were reduced. Immunoglobulin replacement therapy and antibiotic prophylaxis were ineffective. HSCT may be a curative therapeutic option for all patients at the early stage of life.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Infectious Diseases
Efosa Bolaji Odigie, Abdulganiy Abu-Ubaid Zakariyya, Nosa Terry Omorodion, Blessing Emosho Ogeyehme, Theophilus Ogie Erameh, Fatima Bashir Shema, Dahiru Falalu Ibrahim, Oladoyin Atanda, Oyedele Oyewumi Ajayi, David Temitope Noah, Abdullahi Alhaji Mairiga, Abdulaziz Tahir Idris, Sharafudeen Dahiru Abubakar, Zakariyya Muhammad Bello, Halima Saliu Aliu
Summary: This paper discusses the health and workplace-related hazards faced by medical laboratory personnel, especially in the context of the COVID-19 pandemic. It highlights the need for mitigating measures to prevent exposure to and spreading of SARS-CoV-2 in histopathology laboratories, with a focus on promoting safety consciousness and safe laboratory practices among healthcare providers.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Endocrinology & Metabolism
Shaghayegh Khanmohammadi, Tannaz Moeini Shad, Samaneh Delavari, Paniz Shirmast, Yasser Bagheri, Gholamreza Azizi, Asghar Aghamohammadi, Hassan Abolhassani, Reza Yazdani, Nima Rezaei
Summary: This study found that Specific Antibody Deficiency (SAD) is more frequent in Ataxia-telangiectasia (A-T) patients than selective immunoglobulin A deficiency (SIgAD) patients. The role of marginal zone B cells and T cells should not be underestimated in SAD.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Immunology
Niusha Sharifinejad, Majid Zaki-Dizaji, Roya Sepahvandi, Farimah Fayyaz, Maria Marluce dos Santos Vilela, Gehad ElGhazali, Hassan Abolhassani, Hans D. Ochs, Gholamreza Azizi
Summary: IL10 and IL10R deficiencies are genetic defects that cause early-onset inflammatory bowel diseases. Patients with these deficiencies have diverse clinical manifestations and treatment-resistant conditions.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Review
Allergy
Saja Fetyan, Nida Fatima Sakrani, Fawwaz Yassin, Mohammad Fahad Abdallah, Naser Elzein, Gholamreza Azizi, Gehad ElGhazali
Summary: LRBA deficiency is a primary immunodeficiency characterized by hypogammaglobulinemia, recurrent infections, splenomegaly, hepatomegaly, and autoimmune cytopenias. Genetic diagnosis is crucial for tailored treatment.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Fatemeh Aghamahdi, Arman Sha, Sayeh Rostami, Zakiye Mokhames, Mahshid Safavi, Somayeh Yaslianifard, Zeinab Siami, Kourosh Kabir, Gholamreza Azizi, Mahmood Bakhtiyari, Sayed-Hamidreza Mozhgani
Summary: This study evaluated the expression levels of CNR1 and CNR2 genes in COVID-19 patients and diabetic patients, revealing significantly higher expression levels in severe COVID-19 cases. Additionally, the expression levels of these genes were significantly higher in diabetic patients infected with SARS-COV-2 compared to healthy individuals.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Food Science & Technology
Elsa Lamy, Claudia Viegas, Ada Rocha, Maria Raquel Lucas, Sofia Tavares, Fernando Capela e Silva, David Guedes, Monica Laureati, Zeineb Zian, Alessandra Salles Machado, Pierre Ellssel, Bernhard Freyer, Elena Gonzalez-Rodrigo, Jesus Calzadilla, Edward Majewski, Ibrahim Prazeres, Vlademir Silva, Josip Juracak, Lenka Platilova Vorlickova, Antonino Kamutali, Elizabeth Regina Tscha, Keylor Villalobos, Rasa Zelvyte, Ingrida Monkeviciene, Jalila Elati, Ana Maria de Souza Pinto, Paula Midori Castelo, Stephanie Anzman-Frasca
Summary: The COVID-19 pandemic has resulted in significant changes in the behavior and motivations related to food intake. The main motivations for food intake were familiarity and liking. People were categorized into healthier and unhealthier clusters based on their food intake frequency. During the pandemic, there was a decrease in concern for convenience attributes of food and an increase in time and effort dedicated to home cooking.
FOOD QUALITY AND PREFERENCE
(2022)
Article
Immunology
Raouia Fakhfakh, Zeineb Zian, Nesrine Elloumi, Olfa Abida, Emna Bouallegui, Hana Houssaini, Elisabetta Volpe, Alessia Capone, Hend Hachicha, Sameh Marzouk, Zouhir Bahloul, Hatem Masmoudi
Summary: The differentiation of Th1/Th17 cells is altered in systemic lupus erythematosus (SLE), which has a significant impact on the development and severity of the disease.
IMMUNOLOGIC RESEARCH
(2022)
Review
Cell Biology
Maryam Hemmatzadeh, Elham Ahangar Parvin, Hamed Mohammadi, Gholamreza Azizi, Navid Shomali, Farhad Jadidi-Niaragh
Summary: Rheumatoid arthritis is an autoimmune chronic disorder characterized by immune cell involvement, genetic predisposition, and inflammatory responses. The pathogenesis of RA is mainly regulated through autoimmune irregularity of T and B cells, with immune checkpoint molecules playing a crucial role in modulating immune responses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Immunology
Sepideh Ebrahimi Meimand, Gholamreza Azizi, Reza Yazdani, Negin Sanadgol, Nima Rezaei
Summary: Glycogen storage disease type Ib (GSDIb) is an autosomal recessive disorder caused by mutations of the SLC37A4 gene, leading to various clinical manifestations such as hepatomegaly, renomegaly, neutropenia, hypoglycemia, and lactic acidosis. It may also result in severe long-term complications.
IMMUNOLOGIC RESEARCH
(2023)
Article
Oncology
Sharafudeen Dahiru Abubakar, Mitsuaki Takaki, Hiroshi Haeno
Summary: This study constructs a computational model to investigate the mechanisms of cancer initiation and recurrence. The findings can assist in identifying patients with a higher risk of recurrence and determining the targets for therapeutic intervention.
FRONTIERS IN ONCOLOGY
(2023)