Journal
ADVANCED SCIENCE
Volume 9, Issue 32, Pages -Publisher
WILEY
DOI: 10.1002/advs.202203354
Keywords
interferometric scattering microscopy; lanthanide-doped nanoparticle; resonance; scattering
Categories
Funding
- UTS [PRO18-6128]
- Australian Research Council (ARC) DECRA fellowship [DE200100074]
- ARC [DP190101058, CE200100010]
- China Scholarship Council [201809370076, 201708200004, 201706170027, 201706170028]
- Australian Research Council [DE200100074] Funding Source: Australian Research Council
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It is reported that doping lanthanide ions can engineer the scattering properties of low-refractive-index nanoparticles. The polarizability and scattering cross-section of nanoparticles can be dramatically enhanced by matching the excitation wavelength and ion resonance frequency. Purposely engineered nanoparticles can be used for interferometric scattering microscopy and different nanoparticle types can be identified in living cells.
Light scattering from nanoparticles is significant in nanoscale imaging, photon confinement. and biosensing. However, engineering the scattering spectrum, traditionally by modifying the geometric feature of particles, requires synthesis and fabrication with nanometre accuracy. Here it is reported that doping lanthanide ions can engineer the scattering properties of low-refractive-index nanoparticles. When the excitation wavelength matches the ion resonance frequency of lanthanide ions, the polarizability and the resulted scattering cross-section of nanoparticles are dramatically enhanced. It is demonstrated that these purposely engineered nanoparticles can be used for interferometric scattering (iSCAT) microscopy. Conceptually, a dual-modality iSCAT microscopy is further developed to identify different nanoparticle types in living HeLa cells. The work provides insight into engineering the scattering features by doping elements in nanomaterials, further inspiring exploration of the geometry-independent scattering modulation strategy.
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