The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway

(2020) Xiaomin Ma et al.   Cell Death & Disease

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

(2020) Matthew Sermersheim et al.   Nature Communications

Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors

(2020) Pradip De et al.   Cancers

Glucose-sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis

(2019) Hong-Kun Wu et al.   CIRCULATION

High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture

(2019) Daniel J. Marston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MG53 Inhibits the Progression of Tongue Cancer Cells through Regulating PI3K-AKT Signaling Pathway: Evidence from 3D Cell Culture and Animal Model

(2019) Wei Yin et al.   Small

MG53, a Novel Regulator of KChIP2 and I to,f, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy

(2019) Wenjuan Liu et al.   CIRCULATION

Tendinosis develops from age‐ and oxygen tension‐dependent modulation of Rac1 activity

(2019) Rowena McBeath et al.   AGING CELL

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

(2019) Daniël A. Lionarons et al.   CANCER CELL

Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1

(2019) Mar Lorente et al.   JOURNAL OF CELL SCIENCE

Long noncoding RNA LCAT1 functions as a ceRNA to regulate RAC1 function by sponging miR-4715-5p in lung cancer

(2019) Juze Yang et al.   Molecular Cancer

The role of TRIM family proteins in the regulation of cancer stem cell self-renewal: Concise review

(2019) Anna Maria Jaworska et al.   STEM CELLS

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

(2019) Zehua Bian et al.   Nature Communications

Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

(2019) Lai Wei et al.   Nature Communications

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

(2019) Murali K. Akula et al.   Nature Communications

Crosstalk between Rac1-mediated actin regulation and ROS production

(2018) Alejandro Acevedo et al.   FREE RADICAL BIOLOGY AND MEDICINE

ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients

(2018) Haijing Zhou et al.   LABORATORY INVESTIGATION

Serum Levels of TRIM72 Are Lower among Patients with Colon Cancer: Identification of a Potential Diagnostic Marker

(2018) Zhuoyu Chen et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

miR-365 Regulates Liver Cancer Stem Cells via RAC1 pathway

(2018) Ze-Bin Jiang et al.   MOLECULAR CARCINOGENESIS

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Epidemiology and Management of Hepatocellular Carcinoma

(2018) Laura Kulik et al.   GASTROENTEROLOGY

Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance

(2017) Peter Dietrich et al.   GUT

Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling

(2017) Ke Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Ubiquitin E3 Ligase TRAF6 Exacerbates Ischemic Stroke by Ubiquitinating and Activating Rac1

(2017) Tao Li et al.   JOURNAL OF NEUROSCIENCE

TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex

(2017) P Guo et al.   ONCOGENE

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling

(2017) Amanda Remorino et al.   Cell Reports

Emerging roles ofRAC1in treating lung cancer patients

(2016) T. Zou et al.   CLINICAL GENETICS

RAC1 activation drives pathologic interactions between the epidermis and immune cells

(2016) Mårten C.G. Winge et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice

(2015) Z Tu et al.   CELL DEATH AND DIFFERENTIATION

Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome

(2015) Qing Wei et al.   LABORATORY INVESTIGATION

A role for Rac1 activity in malignant progression of sebaceous skin tumors

(2015) D Frances et al.   ONCOGENE

MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression

(2014) Ying Zhang et al.   Scientific Reports

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

(2013) Jae-Sung Yi et al.   Nature Communications

The E3 Ubiquitin-Ligase HACE1 Catalyzes the Ubiquitylation of Active Rac1

(2011) Stéphanie Torrino et al.   DEVELOPMENTAL CELL

A palmitoylation switch mechanism regulates Rac1 function and membrane organization

(2011) Inmaculada Navarro-Lérida et al.   EMBO JOURNAL

IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation

(2011) Tripat Kaur Oberoi et al.   EMBO JOURNAL

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY