Article
Dentistry, Oral Surgery & Medicine
Nastaran Meschi, Mostafa EzEldeen, Andres Eduardo Torres Garcia, Pierre Lahoud, Gertrude Van Gorp, Wim Coucke, Reinhilde Jacobs, Katleen Vandamme, Wim Teughels, Paul Lambrechts
Summary: REP-LP RF appears to be a viable treatment option for achieving PBH and promoting further RD in necrotic immature permanent teeth. Caution is advised when evaluating REP using PR.
JOURNAL OF ENDODONTICS
(2021)
Review
Chemistry, Multidisciplinary
Maria Eugenia Marcela Castro-Gutierrez, Liliana Argueta-Figueroa, Gisela Fuentes-Mascorro, Adriana Moreno-Rodriguez, Rafael Torres-Rosas
Summary: The focus of the study was on examining different scaffolds for regenerative endodontic procedures, and the main outcomes showed no differences between patients who received REP with scaffolds or only REP, indicating that the blood clot remains the gold standard for REP. However, limitations include the low certainty of evidence and significant heterogeneity in the scaffolds used in the included studies.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jiahua Li, Leilei Zheng, Baraa Daraqel, Jing Liu, Yun Hu
Summary: This retrospective study compared the efficacy of concentrated growth factor (CGF) and platelet-rich fibrin (PRF) as scaffolds in regenerative endodontic therapy (RET). The results showed that both CGF and PRF had similar effects in terms of clinical performance, periapical lesion healing, and root development.
Article
Multidisciplinary Sciences
Jianying Zhang, Feng Li, Tyler Augi, Kelly M. Williamson, Kentaro Onishi, MaCalus Hogan, Matthew D. Neal, James H-C Wang
Summary: Platelet-rich plasma (PRP) containing PLT HMGB1 plays a crucial role in tendon wound healing by reducing inflammation, increasing local HMGB1 levels, and recruiting stem cells to the injured area. The efficacy of PRP treatment for tendon injuries in clinics may be dependent on the presence of PLT HMGB1 in PRP preparations.
Article
Dentistry, Oral Surgery & Medicine
Ana Carolina C. L. Cerqueira-Neto, Marina C. Prado, Andrea C. Pereira, Matheus L. Oliveira, Julio Vargas-Neto, Brenda P. F. A. Gomes, Caio C. R. Ferraz, Jose Flavio A. Almeida, Adriana de-Jesus-Soares
Summary: This study compared clinical and radiographic outcomes of regenerative endodontic procedures (REPs) between interappointment dressing or single-visit protocols. The results showed that both treatment approaches resulted in similar clinical and radiographic outcomes.
JOURNAL OF ENDODONTICS
(2021)
Article
Biotechnology & Applied Microbiology
Shijia Tang, Lin Wang, Yunyang Zhang, Feimin Zhang
Summary: Repairing bone defects caused by trauma or diseases is a primary focus of prosthodontics. Researchers developed a novel biomimetic hydrogel by combining methacrylated alginate and 4-arm poly (ethylene glycol)-acrylate (4A-PEGAcr). The hydrogel was then incorporated with platelet-rich plasma (PRP) and biomineralized to promote bone tissue regeneration. In vitro and in vivo studies showed that the hydrogel had excellent biocompatibility and osteogenic activities.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aladdin Al-Qudah, Mohammad Almomani, Layla Hassoneh, Lama Awawdeh
Summary: This randomized clinical trial aimed to assess and compare the long-term clinical and radiographic outcomes of regenerative endodontic procedures (REPs) using 2 intracanal medicaments. The study found that REPs, using either nonsetting calcium hydroxide (Ca[OH]2) or modified triple antibiotic paste (TAP), exhibited high success and survival rates over a follow-up period of 36 months with equally favorable clinical and radiographic outcome data.
JOURNAL OF ENDODONTICS
(2023)
Article
Biotechnology & Applied Microbiology
Hanxin Xu, Fen Xu, Jiajia Zhao, Caixia Zhou, Jiarong Liu
Summary: The study demonstrates that autologous platelet-rich plasma (PRP) can enhance migration, proliferation, and osteogenic differentiation of dental pulp cells, and this process is strengthened by activating autophagy. Inhibiting autophagy weakens the effects of PRP on cells, while an autophagy activator enhances the promoting effects of PRP.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Tuyet Thi Vi Le, Hoang Minh Lam, Tuyet Thi Diem Hoang, Ha Le Bao Tran
Summary: This study demonstrates that double-dose non-activated PRP treatment can effectively promote endometrial regeneration. The treated models showed restored uterine structure, increased number of glands, and increased thickness of the endometrial area. The number of pregnancies in the treated mouse models was also significantly higher.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2023)
Article
Multidisciplinary Sciences
Lucia Merolle, Barbara Lotti, Pamela Berni, Elisa Bedeschi, Katya Boito, Eleonora Maurizi, Gaia Gavioli, Agnese Razzoli, Roberto Baricchi, Chiara Marraccini, Davide Schiroli
Summary: Blood-derived eye drops are used to treat various ocular surface diseases due to their content of metabolites and growth factors. However, the variability in preparation methods and sources makes it difficult to standardize clinical protocols. Sharing detailed procedure information can contribute to the establishment of common guidelines.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Oncology
Ji Won Kim, Tri Ho Minh, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Young-Mo Kim, Jeong-Seok Choi
Summary: Intralesional injection of activated PRP concentrate has potential for tongue regeneration, wound healing, and neural regeneration with minimal scarring after partial glossectomy. The PRP group showed reduced wound scar contracture, promoted wound healing, and less inflammation and wound fibrosis compared to the hemiglossectomy group. Immunohistochemical staining revealed more intense S100 and neurofilament expressions in the hemiglossectomy + PRP group compared to the hemiglossectomy group.
Review
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Current studies have found that Piezo1 plays an important role in the heart, closely related to cardiac regeneration and angiogenesis, providing new research directions for cardiomyocyte regeneration.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Kaja Troha, Domen Vozel, Matevz Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hocevar, Zala Jan, Matic Kisovec, Bostjan Kocjancic, Ljubisa Paden, Manca Pajnic, Samo Penic, Anna Romolo, Neza Repar, Vesna Spasovski, Nejc Steiner, Vid Sustar, Ales Iglic, Damjana Drobne, Ksenija Kogej, Saba Battelino, Veronika Kralj-Iglic
Summary: The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields. Efforts are being made to understand the function and dynamics of PVRP which is complex in its composition and interactions. A review was performed to better understand the constituents of PVRP and promote further studies on its therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Sayuri Uchino, Yoshitomo Saita, Atsushi Wada, Yohei Kobayashi, Takanori Wakayama, Hirofumi Nishio, Shin Fukusato, Yasumasa Momoi, Ryosuke Nakajima, Hiroshi Ikeda, Muneaki Ishijima
Summary: This study analyzed the blood cell counts of patients with knee OA undergoing PRP therapy and found higher platelet concentration and lower leukocyte concentration in PRP compared to whole blood. The percentage of IPF in whole blood was positively correlated with pain improvement, while the percentage of neutrophil in PRP was significantly associated with pain and ADL improvement. The efficacy of PRP therapy for OA may depend on the patient's biological status.
REGENERATIVE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Machut, Agata Zoltowska, Elzbieta Pawlowska, Marcin Derwich
Summary: This manuscript presents two case reports of permanent teeth with closed apexes treated endodontically with the use of PRF. After 6 months, the periapical lesions were significantly reduced, suggesting successful root canal treatments. Further studies are needed to assess the efficacy of additional PRF application in mature teeth undergoing root canal treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Saurav Panda, Lora Mishra, Heber Isac Arbildo-Vega, Barbara Lapinska, Monika Lukomska-Szymanska, Shahnawaz Khijmatgar, Abhishek Parolia, Cristina Bucchi, Massimo Del Fabbro
Article
Chemistry, Multidisciplinary
Stefania Multari, Mario Alovisi, Elio Berutti, Stefano Corbella, Silvio Taschieri, Giorgia Carpegna, Nicola Scotti, Allegra Comba, Damiano Pasqualini
Summary: Root canal shaping techniques have an impact on postoperative quality of life, with pain being a common complication of root canal treatment. Reciprocating instruments may influence patients' quality of life.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Physical
Gianluca Martino Tartaglia, Pier Paolo Poli, Stephen Thaddeus Connelly, Carlo Maiorana, Davide Farronato, Silvio Taschieri
Summary: In sinus floor augmentation, using xenograft material is more successful than using blood clot alone when the residual alveolar bone height is between 4-6 mm. Sinus floor augmentation with grafting materials should be preferred when the residual alveolar bone height is low.
Review
Chemistry, Physical
Alice Alberti, Luca Francetti, Silvio Taschieri, Stefano Corbella
Summary: Enamel matrix derivative (EMD) has shown promising results in promoting bone regeneration and osseointegration in combination with titanium implants. However, further randomized clinical trials are needed to assess its efficacy for peri-implant bone defects and peri-implantitis treatment protocols.
Review
Biochemistry & Molecular Biology
Alessio Danilo Inchingolo, Gianna Dipalma, Angelo Michele Inchingolo, Giuseppina Malcangi, Luigi Santacroce, Maria Teresa D'Oria, Ciro Gargiulo Isacco, Ioana Roxana Bordea, Sebastian Candrea, Antonio Scarano, Benedetta Morandi, Massimo Del Fabbro, Marco Farronato, Gianluca Martino Tartaglia, Mario Giosue Balzanelli, Andrea Ballini, Ludovica Nucci, Felice Lorusso, Silvio Taschieri, Francesco Inchingolo
Summary: COVID-19, caused by SARS-CoV-2, emerged in Wuhan in December 2019 and quickly spread globally. Various treatments such as antivirals and immunomodulators may benefit patients, but no definitive protocol has proven efficacy. Mass vaccination is considered the best option for defeating the disease in the future.
Article
Biochemistry & Molecular Biology
Cristina- Bucchi, Ella Ohlsson, Josep Maria de Anta, Melanie Woelflick, Kerstin Galler, Maria Cristina Manzanares-Cespedes, Matthias Widbiller
Summary: Pluripotent stem cells derived from the amnion show the ability to adhere to dentin and mineralize in vitro, but exhibit unfavorable proliferation behavior and fail to undergo odontoblastic transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Silvio Taschieri, Margherita Tumedei, Luca Francetti, Stefano Corbella, Massimo Del Fabbro
Summary: The study aimed to evaluate the efficacy of a toothpaste containing 67% sodium bicarbonate in improving gingival health parameters. The results showed significant improvements in gingival index, bleeding index, and plaque index in patients using the toothpaste, indicating that it can improve periodontal health.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Cristina Bucchi, Eyal Rosen, Silvio Taschieri
Summary: Apical surgery and non-surgical treatment or retreatment are both options for managing teeth with apical periodontitis, but it is unclear which option is more effective. This systematic review found that apical surgery showed better results in terms of periapical healing and reducing the need for further intervention, although tooth survival rate was higher in the non-surgical treatment group. However, due to the heterogeneity of the studies, meta-analysis was not possible, and further high-quality comparative trials are needed to draw statistically supported conclusions.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Cristina Bucchi, Massimo Del Fabbro, Jordi Marce-Nogue
Summary: This study utilized finite element analysis to investigate the stress distribution in tooth structures under orthodontic loads, finding that mature teeth with dentine or cementum reinforcement have reduced stress values in the periodontal ligament, indicating safe orthodontic treatment. Further in vivo studies will be important to validate these findings.
APPLIED SCIENCES-BASEL
(2022)
Review
Nutrition & Dietetics
Camila Venegas, Nicole Farfan-Beltran, Cristina Bucchi, Jordi Martinez-Gomis, Ramon Fuentes
Summary: This systematic review analyzed the effect of chewing behavior modification on obesity-related parameters. The evidence suggests that modifying chewing behavior can reduce eating rate, improve satiety, and have long-term effects on body mass index.
REVISTA CHILENA DE NUTRICION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cristina Bucchi, Ana Bucchi, Paulina Martinez-Rodriguez
Summary: This study aimed to assess the impact of inflammatory status of the dental pulp and the sustained inflammatory environment on the biological characteristics of dental pulp stem cells (DPSCs). The results showed that the inflammatory status of the pulp significantly reduced the viability and mineralization capacity of DPSCs, while it did not affect the adhesion capacity to dentin or the secretion of proinflammatory cytokines. The inflammatory microenvironment had a significant impact on the secretion of interleukin 6.
JOURNAL OF ENDODONTICS
(2023)
Article
Anatomy & Morphology
Cristina Bucchi, Josep Maria De Anta
Summary: This study describes a method for isolating human amnion epithelial cells (hAECs) from cesarean delivery placentas and investigates their characterization and culture conditions. The results show that hAECs have limited proliferation capacity but can be isolated easily and effectively using a simple protocol.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. Bucchi, S. Arroyo-Bote
Summary: The study aimed to evaluate dentists' knowledge levels of treating dental injuries, finding that dentists need to improve their knowledge and understanding regarding the treatment of tooth intrusion, lateral luxation, and avulsion of mature teeth as well as the use of splinting. While demographic factors did not significantly affect knowledge levels, the study revealed uneven knowledge among dentists depending on the type of dental trauma injury.
EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY
(2021)
Article
Anthropology
Ana Bucchi, Javier Luengo, Maria Cristina Manzanares-Cespedes, Cristina Bucchi, Carlos Lorenzo
HOMO-JOURNAL OF COMPARATIVE HUMAN BIOLOGY
(2020)