Journal
LIGHT-SCIENCE & APPLICATIONS
Volume 11, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41377-022-00864-y
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Funding
- National Key RAMP
- D Program of China [2020YFA0908900, 2021YFB3502300, 2020YFA0712102]
- National Natural Science Foundation of China [21834007, 22020102003, 22107097, 21907088, 22125701]
- Youth Innovation Promotion Association of CAS [2020228, 2021226]
- China Postdoctoral Science Foundation [2020M681055]
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Rare-earth based materials with unique optical properties, superior magnetism, and high X-ray absorption abilities are promising for high-resolution brain imaging and therapy. When combined with biomolecules, rare-earth based materials can overcome the blood-brain barrier and enable targeted treatment for brain diseases.
Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced.
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