Article
Endocrinology & Metabolism
Bunpei Ishizuka, Masataka Furuya, Machiko Kimura, Eri Kamioka, Kazuhiro Kawamura
Summary: The study analyzed the effectiveness of HR treatment on patients with POI, showing that OS combined with HR therapy can increase fertility rates, especially in the IVF-1-a and IVF-2 groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Yueming Xu, Jie Zhang, Aimin Li, Ni Yang, Na Cui, Guimin Hao, Bu-Lang Gao
Summary: Elevated progesterone levels during the late follicular phase significantly impact early pregnancy outcomes and live births among IVF/ICSI patients after fresh embryo transfers. With increasing progesterone levels, clinical pregnancy rate, intrauterine pregnancy rate, and live birth rate all decrease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Agnieszka Katarzyna Warzecha, Mette Villads Nielsen, Claus Yding Andersen, Marianne Dreyer Holt, Morten Ronn Petersen, Negjyp Sopa, Anne Zedeler, Anne Lis Englund, Anja Pinborg, Marie Louise Grondahl, Sven Olaf Skouby, Nicholas Stephen Macklon
Summary: LZ co-treatment during ovarian stimulation with gonadotropins for in IVF does not impact follicle recruitment, oocyte number and quality, embryo quality, or live birth rate (LBR).
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Rulan Jiang, Mingya Cao, Haomeng Hao, Rui Jia, Peipei Chen, Yuanyuan Liu, Zhiming Zhao
Summary: The follicular output rate (FORT) has significant effects on the cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR) in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF) treatment. A higher FORT is beneficial for achieving better pregnancy outcomes, especially for patients with polycystic ovarian morphology, ovulation disorder, or hyperandrogenic manifestations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Giulia Scaravelli, Carlotta Zaca, Paolo Emanuele Levi Setti, Claudia Livi, Filippo Maria Ubaldi, Maria Teresa Villani, Ermanno Greco, Maria Elisabetta Coccia, Alberto Revelli, Giuseppe Ricci, Francesco Fusi, Vincenzo Vigiliano, Roberto De Luca, Simone Bolli, Andrea Borini
Summary: The study revealed a positive association between fertilization rate and CLBR, suggesting the predictive clinical relevance of this parameter and its adoption as a key performance indicator.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Efstathios Theodorou, Benjamin P. Jones, Suzanne Cawood, Carleen Heath, Paul Serhal, Jara Ben-Nagi
Summary: When only one high-quality blastocyst is available, transferring an additional low-quality blastocyst may slightly increase the live birth rate, but significantly increases the twin rate. When two high-quality blastocysts are available, transferring both in a double embryo transfer can result in higher live birth rate and lower miscarriage rate, but also significantly increases the risk of twin gestation compared to a single embryo transfer.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Lin Qi, Ya-ping Liu, Shi-ming Wang, Hao Shi, Xiao-li Chen, Ning-ning Wang, Ying-chun Su
Summary: This study investigated the impact of BMI in male and/or female partners on embryo development and clinical pregnancy outcome during assisted reproductive technology (ART). The results showed that higher female BMI was associated with lower formation of high-quality embryos in the ICSI cycle. Both female and/or male BMI had a greater impact on the implantation rate (AR) and live birth rate (LBR) compared to the clinical pregnancy rate (CPR), in both IVF and ICSI cycles.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Lifeng Tian, Leizhen Xia, Hongbo Liu, Yan Kou, Zhihui Huang, Xingwu Wu, Lu Fan, Jialyu Huang, Qiongfang Wu
Summary: This study aimed to investigate the relationship between blastomere number on day 3 and pregnancy outcomes. The results showed that an increased blastomere number was associated with a higher live birth rate in single day 3 embryo transfer cycles. This finding challenges the consensus on the reduced developmental potential of fast-cleaving embryos, and further large prospective studies are needed for confirmation.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Paolo Emanuele Levi-Setti, Andrea Busnelli, Roberto De Luca, Giulia Scaravelli
Summary: The study indicates that strategies favoring frozen-thawed embryo transfer (FET) are associated with increased cumulative live birth rate (CLBR), decreased weighted mean cost per live birth, and reduced multiple pregnancy rate (MPR).
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rui Jia, Yuanyuan Liu, Rulan Jiang, Xuli Zhu, Liang Zhou, Peipei Chen, Mingya Cao, Zhiming Zhao
Summary: This study aimed to determine the optimal number of oocytes retrieved for patients with PCOS undergoing IVF to achieve the best CLBR and live birth after fresh embryo transfer. The study found that the number of oocytes retrieved was an independent protective factor for CLBR, with a higher CLBR observed when the number of oocytes retrieved was 15 or more. Patients with 7-16 oocytes retrieved had a greater chance of live birth after fresh embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoyuan Xu, Aimin Yang, Yan Han, Wei Wang, Guimin Hao, Na Cui
Summary: This retrospective cohort study analyzed the association between serum E2 levels on the hCG trigger day and LBRs. The results showed a positive association between serum E2 levels and LBRs, especially in patients with low follicle counts on the trigger day. Additionally, a two-piecewise linear regression model demonstrated a strong positive association between serum E2 and LBR when the E2 concentration was below 2.1 ng/ml.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Jianjun Hu, Emanuela Molinari, Sarah K. Darmon, Lin Zhang, Pasquale Patrizio, David H. Barad, Norbert Gleicher
Summary: The study found that the granulation patterns of donor oocytes are predictive of IVF success rates, with higher quality granulation patterns associated with higher pregnancy and live birth rates in fresh donor oocytes. Similar trends were observed in thawed donor oocytes, but with relatively worse outcomes.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Meng Wang, Lei Jin, Juanzi Shi, Yundong Mao, Cuilian Zhang, Rui Huang, Xiaoyan Liang
Summary: This study aimed to assess the effects of estradiol (E2) levels on trigger day on cumulative live birth rates (CLBRs) and pregnancy outcomes after fresh and frozen-thawed embryo transfer (FET). The results showed that CLBR increased by 10% for every 1000 pg/mL increase in E2 when E2 was <5500 pg/mL. When E2 levels were between 5500 and 13,281 pg/mL, CLBR increased by 1.8% for every 1000 pg/mL increase in E2. CLBR decreased by 3% for every 1000 pg/mL increase in E2 when E2 was >13,281 pg/mL. The live birth rate in FET cycles was highest in the group with E2 >= 5000 pg/mL.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Yaxin Guo, Shuai Liu, Shiqiao Hu, Fei Li, Lei Jin
Summary: The study revealed that higher baseline AMH levels in PCOS patients are associated with lower LBR, CPR, and FR, but do not impact CLBR.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jennifer K. Y. Ko, Jinghua Shi, Raymond H. W. Li, William S. B. Yeung, Ernest H. Y. Ng
Summary: This study found that vitamin D deficiency was prevalent in infertile women in subtropical Hong Kong. The cumulative live birth rate of the first IVF cycle was significantly lower in the vitamin D-deficient group compared to the non-deficient group.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
N. Gleicher, D. F. Albertini, D. H. Barad, H. Homer, D. Modi, M. Murtinger, P. Patrizio, R. Orvieto, S. Takahashi, A. Weghofer, S. Ziebe, N. Noyes
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2020)
Article
Engineering, Electrical & Electronic
Etienne Puyoo, David Albertini
IEEE ELECTRON DEVICE LETTERS
(2020)
Article
Genetics & Heredity
D. Bebbere, A. Abazari-Kia, S. Nieddu, B. Melis Murgia, D. F. Albertini, S. Ledda
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Correction
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Editorial Material
Genetics & Heredity
David F. Albertini
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Valentina Lodde, Alberto Maria Luciano, Giulia Musmeci, Ileana Miclea, Irene Tessaro, Mariella Aru, David F. Albertini, Federica Franciosi
Summary: Women's reproductive performance declines starting in midlife, with a very low possibility of pregnancy by age 40-45. Premature ovarian failure and early ovarian aging can lead to low-quality eggs, impacting fertility. Understanding cellular mechanisms is essential for finding solutions to reproductive aging issues.
Article
Obstetrics & Gynecology
D. H. Barad, D. F. Albertini, E. Molinari, N. Gleicher
Summary: This study aimed to investigate the effects of intraovarian injection of platelet-rich plasma (PRP) on ovarian function in patients with extremely low functional ovarian reserve (LFOR). The results showed that PRP treatment did not have clinically significant effects on ovarian function over a 1-year follow-up period. However, two patients with poor prognosis achieved pregnancy after PRP treatment. The study suggests that sporadic pregnancies are possible even in extremely poor prognosis patients due to LFOR, but further research is needed to determine the role of PRP treatments in these pregnancies.
HUMAN REPRODUCTION OPEN
(2022)
Article
Endocrinology & Metabolism
Norbert Gleicher, Sarah Darmon, Emanuela Molinari, Lin Zhang, Jianjun Hu, David F. Albertini, David H. Barad
Summary: This study found that young women under the age of 41 with adrenal hypoandrogenism may actually suffer from secondary ovarian insufficiency (SOI) rather than primary ovarian insufficiency (POI). In some cases, this condition could be treated with androgen supplementation.
Meeting Abstract
Obstetrics & Gynecology
Jianjun Hu, Lin Zhang, David F. Albertini, Emanuela Molinari, David H. Barad, Norbert Gleicher
FERTILITY AND STERILITY
(2020)
Meeting Abstract
Obstetrics & Gynecology
Jianjun Hu, Min Yang, Lin Zhang, David F. Albertini, Emanuela Molinari, David H. Barad, Norbert Gleicher
FERTILITY AND STERILITY
(2020)
Meeting Abstract
Obstetrics & Gynecology
Min Yang, Tiago Rito, Jeffrey Naftaly, Jianjun Hu, David F. Albertini, David H. Barad, Ali H. Brivanlou, Norbert Gleicher
FERTILITY AND STERILITY
(2020)
Meeting Abstract
Obstetrics & Gynecology
D. Barad, D. Albertini, E. Molinari, N. Gleicher
HUMAN REPRODUCTION
(2020)
Article
Developmental Biology
David F. Albertini
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)