Article
Biotechnology & Applied Microbiology
Na Li, Jianjun Lin, Chunping Liu, Qian Zhang, Riwang Li, Chuang Wang, Chaochao Zhao, Lu Lu, Changren Zhou, Jinhuan Tian, Shan Ding
Summary: The efficacy of chemotherapy for solid tumors is hindered by dose-limiting toxicity and heterogeneous drug distribution caused by the dense extracellular matrix. In situ-formed hydrogels at the tumor site show potential in promoting drug accumulation, retention, and long-lasting release, overcoming these obstacles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jingshu Meng, Xiao Yang, Jing Huang, Zhan Tuo, Yan Hu, Zhiyun Liao, Yu Tian, Suke Deng, Yue Deng, Zhiyuan Zhou, Jonathan F. Lovell, Honglin Jin, Yang Liu, Kunyu Yang
Summary: This study presents an injectable hydrogel drug delivery system based on chitosan hydrochloride and oxidized dextran (CH-OD) for loading sulfasalazine (SSZ) to effectively treat malignant ascites in advanced hepatocellular carcinoma (HCC). The CH-OD-SSZ hydrogel exhibits enhanced cytotoxicity and immunogenic ferroptosis compared to free SSZ. In preclinical models, the intraperitoneal administration of CH-OD-SSZ hydrogel significantly suppresses tumor progression, repolarizes macrophages, activates dendritic cells, and achieves ascites regression when combined with anti-PD-1 immunotherapy.
Article
Chemistry, Applied
Wenxue Zhang, Yan Shi, Hu Li, Miao Yu, Jiaxuan Zhao, Hao Chen, Ming Kong
Summary: A novel in situ injectable nano-complexed hydrogel was developed in this study for combining tumor therapy, which could regulate TAMs polarization and alleviate hypoxia in the tumor microenvironment to improve the anti-tumor therapeutic efficacy.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Haolei Shi, Dongxu Ma, Di Wu, Xiao Qiu, Shuai Yang, Yingying Wang, Lei Xiao, Xinyao Ji, Wei Zhang, Shuaiyuan Han, Pengfei Huo, Jidong Dong, Xianzhi Kong, Xue Guan, Dawei Zhang
Summary: A smart hydrogel with pH-responsive, injectable, and self-healing properties was prepared for controlled drug release. The hydrogel demonstrated tunable drug release rate and shape, and showed no cytotoxicity. Animal experiments revealed favorable biodegradability and compatibility of the hydrogel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Hamidreza Garshasbi, Saba Salehi, Seyed Morteza Naghib, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Injectable hydrogels have gained significant attention in the past decade for their functional properties in drug delivery, particularly in precise, non-invasive, and targeted tissue locations. The development of drug delivery systems that are responsive to hydrogel stimuli to release drugs under various external stimuli is a challenging task. Chitosan-based hydrogels, known for their biocompatibility, mucosal adhesion, and hemostatic activity, hold great potential for tissue engineering and drug delivery. However, managing the structure of stimuli-responsive chitosan hydrogels or incorporating additional crosslinking agents, such as those with dual pH and thermo-responsiveness, can be difficult. Therefore, it is crucial to create these hydrogels for medicinal applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Marcella Matos Cordeiro Borges, Bruna Carneiro Pires, Sara Silveira Vieira, Keyller Bastos Borges, Luiz Gustavo de Lima Guimaraes
Summary: A novel magnetic and pH responsive composite hydrogel based on poly(2-(diethylamino)ethyl methacrylate)/chitosan was synthesized and investigated for fipronil removal from aqueous medium. The adsorbent showed high efficiency with an adsorption rate of 80% under optimal conditions of pH 4, 25 mg of adsorbent, and stirring for 60 s. The kinetic and isothermal models provided insights into the adsorption mechanism and demonstrated the potential for removing fipronil from wastewater.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Lianlian Yang, Junhong Ling, Nan Wang, Yongjun Jiang, Yuqing Lu, Li-Ye Yang, Xiao-kun Ouyang
Summary: GMA was used to modify CMCS to prepare nanogels for targeted delivery of DOX. The experimental results showed that GCMCS-FA-DOX had high glutathione and pH responsiveness, exhibited excellent inhibitory effect on tumor cell proliferation, and improved drug uptake efficiency.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biophysics
Ziqi Wang, Wen Zeng, Zhiran Chen, Weilong Suo, Hong Quan, Zhi-Jie Tan
Summary: Utilizing a hybrid light-controlled hydrogel system, this study developed an injectable nanoplatform using Prussian Blue nanoparticles for thermoradiotherapy. Under near-infrared laser irradiation, PB nanoparticles release heat energy and drive the decomposition of endogenous hydrogen peroxide to improve tumor hypoxic microenvironment, enhancing radiation sensitivity. The PRC demonstrated excellent effects of PTT-RT in vitro and in vivo, indicating its potential for anti-cancer combination thermoradiotherapy with greater clinical significance.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Xiaosheng Tao, Fujian Jiang, Kang Cheng, Zhenzhen Qi, Vamsi K. Yadavalli, Shenzhou Lu
Summary: The study introduces a new conjugated material, cationic silk fibroin (CSF), created through chemical modification of silk fibroin with epsilon-Poly-(L-lysine) (epsilon-PLL), that demonstrates excellent pH responsiveness and swelling behavior. Additionally, the CSF hydrogel shows glucose-responsive properties when glucose oxidase (GOx) is added, providing potential for rapid drug release applications. The versatility and biological properties of fibroin make stimuli-responsive silk hydrogels promising for intelligent drug delivery and other biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pingping Sun, Jingmiao Jiao, Xiaoyu Wang, Long Chen, Zhiyong Chen, Kun Zhang, Kai Qu, Xian Qin, Zailiang Yang, Julia Li Zhong, Wei Wu
Summary: A multifunctional nanocomposite hydrogel (CS-HCA-Icps) with a pathological pH-responsive drug release has been developed to promote wound healing impaired by microbial infection. The hydrogel composed of catechol-grafted chitosan (CS-HCA) and a curcumin-Fe3+ coordination nanoparticles (Icps, Cur-Fe3+) exhibits favorable activities in free radical scavenging, anti-bacterial, and anti-inflammatory. It also shows good biocompatibility in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaojing Zhang, Yang Meng, Weiwei Shen, Jingcheng Dou, Ruixue Liu, Qingxian Jin, Shaoming Fang
Summary: This study successfully prepared a family of injectable nanocomposite hydrogels through the Schiff base reaction between OCAPS, CS, and HPC, demonstrating good biocompatibility and biodegradability. The addition of OCAPS enhanced the mechanical properties and drug load efficiency of the hydrogels, showing great potential for drug delivery and tissue engineering applications.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Medicine, Research & Experimental
Ruihao Yang, Shiyan Fu, Ruidong Li, Lei Zhang, Zhigang Xu, Yang Cao, Hongjuan Cui, Yuejun Kang, Peng Xue
Summary: ROS have potential in eliminating tumor cells in situ, with the help of SF for synthesis of metallic nanocrystals. The nanozyme developed from this process showed antitumor effects by continuously supplying H2O2 in vitro and depleting GSH intracellularly.
Article
Engineering, Environmental
Amrita Singh, Aditya K. Kar, Divya Singh, Rahul Verma, Nikita Shraogi, Alina Zehra, Krishna Gautam, Sadasivam Anbumani, Debabrata Ghosh, Satyakam Patnaik
Summary: The study presents an innovative pesticide formulation using chitosan-alginate-cenosphere composite hydrogel beads for sustained release of imidacloprid, with high encapsulation efficiency and slower release profile under different pH conditions. The formulation shows promise for on-field application and sustainable pest management, as supported by various experiments and safety assessments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Applied
Wentao Wang, Qicheng Zhang, Ming Zhang, Xintong Lv, Zihan Li, Mohsen Mohammadniaei, Ninglin Zhou, Yi Sun
Summary: A novel therapeutic nanocomposite was developed for wound bacterial infections and tumor recurrence, utilizing released reactive oxygen species to kill bacteria and inhibit tumor cell regeneration, as well as utilizing photothermal properties to penetrate the blood tumor barrier for brain tumor treatment. The combination of the nanocomposite with immunotherapy showed potential for improving postoperative therapy and multi-tumor treatments.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Liubing Li, Jun Gu, Jie Zhang, Zonggang Xie, Yufeng Lu, Liqin Shen, Qirong Dong, Yangyun Wang
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Chemistry, Medicinal
Jun Gu, Zheng Shuai Jin, Chun Ming Wang, Xue Fei Yan, Yuan Qing Mao, Sheng Chen
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Chemistry, Analytical
Yanxian Wu, Jun Gu, Shaodian Zhang, Yuan Gu, Jie Ma, Yangyun Wang, Leshuai W. Zhang, Yong Wang
Summary: The development of novel iodinated bovine serum albumin nanoparticles for computed tomography (CT) imaging and repair of acute gastritis based on gastritic microenvironment has shown promising results. These pH-sensitive nanoparticles can sediment under acidic conditions and be uniformly distributed in the defected mucosa through phagocytosis of inflammatory cells. The nanoparticles have potential in accurate diagnosis and treatment of gastritis in the early stage by repairing atrophic gastric mucosa and enhancing CT images.
ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Xinzhu Zhang, Wu Xiong, Guang Kong, Yushan Zhen, Qiang Zeng, Siming Wang, Sheng Chen, Jun Gu, Cong Li, Kaijin Guo
Summary: This study introduces a new drug loading system that encapsulates paclitaxel into spermine-functionalized acetal-dextran nanoparticles. The sustained release of paclitaxel for 4 days can promote nerve process extension and reduce scar formation in a rat spinal cord injury model. This neuroprotective treatment shows better therapeutic effects compared to traditional paclitaxel treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jun Gu, Lijun Pang, Donghua Yan, Chunming Wang, Yuekun Song, Zhengshuai Jin, Zhenwei Xu, Yuanqing Mao, Shengzhe Liu, Sheng Chen
Summary: This study reveals the important role of the ubiquitin-proteasome system in the low-grade glioma tumor microenvironment. By analyzing the ubiquitination modification patterns and their associations with tumor immune traits, stemness, and cellular senescence, this research provides insights into the personalized and effective immunotherapeutic tactics for low-grade glioma.