Article
Engineering, Biomedical
Yang Zhou, Kang Chen, Wing Kak Lin, Jinzhao Liu, Weirong Kang, Yaming Zhang, Ranyao Yang, Leigang Jin, Yiyun Cheng, Aimin Xu, Weiping Wang
Summary: This study developed a novel strategy to trigger ferroptosis by PDT and FSP1 inhibition, using a photoresponsive nanocomplex self-assembled by BODIPY-modified poly(amidoamine) (BMP) to stably encapsulate the inhibitor of FSP1 (iFSP1) and chlorin e6 (Ce6). The nanosystem demonstrated high-performance triggering of ferroptosis and immunogenic cell death (ICD) in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Danqi Li, Jingli Ren, Jun Li, Yamin Zhang, Yuchen Lou, Jinjin Zhu, Pei Liu, Yu Chen, Zhen Yu, Liang Zhao, Lianbin Zhang, Xiang Chen, Jintao Zhu, Juan Tao
Summary: The study developed a nanotechnology-based PDT strategy for melanoma treatment, utilizing mesoporous coated upconverting nanoparticles to convert NIR light to UV-vis light, enabling deep tissue destruction and enhancing anti-tumor immunity. By elevating levels of hydroxyl radicals and inducing apoptosis, the strategy aimed to ease tumor burden and amplify intratumoral oxidative stress.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Huocheng Yang, Xuemei Yao, Yingqi Liu, Xinkun Shen, Menghuan Li, Zhong Luo
Summary: Ferroptosis, a regulated cell death driven by iron-dependent phospholipid peroxidation, has gained attention in nanomedicine since 2012. It has unique features compared to other cell death modes and shows promise in treating resistant cancers. Recent insights suggest its connection to the tumor immune microenvironment, indicating its potential in stimulating antitumor immunity. Understanding the relationship between tumor metabolism and ferroptosis is important for developing antitumor therapies.
Article
Chemistry, Multidisciplinary
Xiaolong Liang, Min Chen, Pravin Bhattarai, Sadaf Hameed, Yida Tang, Zhifei Dal
Summary: The study presents a theranostic nanoplatform based on Fe3O4@PGL NPs, which showed outstanding therapeutic effects against cancer cells through excellent self-assembling nature, high loading of porphyrins, and photodynamic effects.
Article
Cell Biology
Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Ye An, Meng-Yao Xu, Zheng Liu, Jia Hu, Shao-Gang Wang
Summary: In this study, different ferroptosis patterns were identified and a ferroptosis scoring system was established in bladder cancer patients. The results showed that ferroptosis patterns were closely related to clinical characteristics, prognosis, immune cell infiltration in the tumor microenvironment, and could be used to guide clinical treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Wenbo Han, Xiaopin Duan, Kaiyuan Ni, Youyou Li, Christina Chan, Wenbin Lin
Summary: This study demonstrates the enhanced antitumor efficacy of DHA through co-delivery with a cholesterol derivative and an iron complex in nanoparticles. The combination treatment also improves tumor immunogenicity, making non-immunogenic colorectal tumors more susceptible to immunotherapy.
Review
Pharmacology & Pharmacy
Fan Zeng, Yunping Lan, Ning Wang, Xiaobo Huang, Qiao Zhou, Yi Wang
Summary: Bladder cancer, the most frequent type of urinary system cancer, has a poor prognosis due to high metastasis rates and multidrug resistance. The development of novel therapies targeting bladder cancer cell death is urgently needed. Ferroptosis, a novel cell death type with strong antitumor potential, has been investigated by many groups for its potential in bladder cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qixiong Lu, Xiaoyang Lu, Yuansheng Zhang, Wei Huang, Hu Zhou, Tao Li
Summary: Ferroptosis is a form of cell death characterized by excessive iron-dependent lipid peroxidation. It disrupts the cellular antioxidant capacities and leads to oxidative overload and cell death. Ferroptosis plays a significant role in various diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qifang Chen, Xianbin Ma, Li Xie, Wenjie Chen, Zhigang Xu, Erqun Song, Xiaokang Zhu, Yang Song
Summary: The nanosystem designed in this study, coated with FDA approved PLGA, Fe3O4, and Ce6, is capable of synergistic ferroptosis-photodynamic anticancer therapy by releasing ferrous/ferric ions and Ce6 in the acidic TME for Fenton reaction and ROS generation under laser irradiation. The nanosystem also possesses excellent MRI properties and highly efficient tumor suppression in vivo due to the synergism of photodynamic and ferroptosis antitumor therapies.
Article
Chemistry, Multidisciplinary
Yongjuan Li, Ningjing Lei, Xiaohan Yao, Yu Zhang, Ya Dong, Jinmeng Yi, Xinyan Li, Wenjing Deng, Guangjun Nie, Zhihai Qin
Summary: A polyvalent ferroptosis agonist, hPPAA18C6, is developed to stimulate ferroptosis by releasing endogenous iron and depleting glutathione in hypoxia. In addition, hPPAA18C6 acts as an immune adjuvant, facilitating dendritic cells maturation and CD8(+) T-cell activation. The combination of hPPAA18C6 and Ce6 leads to combined therapeutic outcomes in primary, distant, and metastatic tumors.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qiubo Ding, Weinan Tang, Xianglong Li, Yuanzhen Ding, Xinnan Chen, Wenmin Cao, Xinwu Wang, Wenjing Mo, Zhigui Su, Qing Zhang, Hongqian Guo
Summary: The study developed a mitochondrial-targeted liposome loaded with brequinar to enhance ferroptosis in bladder cancer cells, which promotes the release of immunogenic cell death-related molecules and improves the effectiveness of immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Ronan Talty, Marcus Rosenberg
Summary: Melanoma is a deadly form of skin cancer with current treatments not benefiting all patients. Ferroptosis, a newly identified iron-dependent cell death form, is linked to the development of several cancers including melanoma. Future directions in melanoma treatment may involve targeting ferroptosis to improve outcomes.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Caiju Zhang, Shuting Lu, Kai Deng, Wang Qian, Yue Liu, Yi Li, Shiqi Jin, Ruiyang Suo, Haibo Xu, Bo Wu
Summary: This study proposes an X-ray-activated iron ion supply platform for tumor therapy. The platform utilizes a CaWO4 nanoscintillator to emit UV light under X-ray excitation, which catalyzes ferrous to generate highly toxic hydroxyl radicals through the Fenton reaction. Immunotherapy is also triggered during this process. The platform shows superior tumor therapeutic efficacy and can be used as an MR/CT dual-mode imaging contrast agent for tumor diagnosis and treatment monitoring.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Medicine, Research & Experimental
Jumei Yin, Xingqi Meng, Lixuan Peng, Wei Xie, Xuan Liu, Weiguo He, Suyun Li
Summary: Traditional treatment strategies for cancer are unsatisfactory. Ferroptosis, a non-apoptotic cell death process characterized by iron-dependent lipid peroxide accumulation, has emerged as a new target for tumor treatment. Studies have shown that ferroptosis can enhance the immunogenicity of cancer and interact with immune cells. By inducing iron deposition-based ferroptosis, natural and adaptive immune responses can be stimulated, leading to immune-stimulating factors inducing iron deposition in cancer cells.
CURRENT MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Shuzheng Tan, Ying Kong, Yongtong Xian, Pengbo Gao, Yue Xu, Chuzhong Wei, Peixu Lin, Weilong Ye, Zesong Li, Xiao Zhu
Summary: Ferroptosis is a newly discovered non-apoptotic cell death mode that is distinct from classical cell death modes. It is characterized by the accumulation of iron dependence and lipid peroxides. Identifying key sites of ferroptosis in diseases is crucial, and it is also linked to tumor development, providing personalized plans for cancer patients. Despite the need for further study on its mechanisms and side effects, ferroptosis remains a promising method for cancer treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hsu
Summary: This study suggests that lenvatinib can enhance the anti-hepatocellular carcinoma (HCC) efficacy of radiation therapy (RT) by inhibiting Src/STAT3/NF-KB signaling. The findings reveal the role of targeting Src and its regulation of epithelial-mesenchymal transition (EMT) in increasing the sensitivity of HCC to radiation. Lenvatinib and sorafenib, both multikinase inhibitors, are effective in treating HCC.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Li-Cho Hsu, Chen-Yu Kuo, Fei -Ting Hsu, Hsin Feng Chang, Jing-Jim Ou
Summary: This study found that hyperforin, an active constituent from Hypericum perforatum, suppresses the progression and transformation of colorectal cancer (CRC) by inhibiting the JAK/STAT3, ERK, and AKT signaling pathways, suggesting its therapeutic potential.
Review
Medicine, Research & Experimental
Yuan-Hua Wu, Rong-Jane Chen, Hui-Wen Chiu, Li-Xing Yang, Yung-Li Wang, Yu-Ying Chen, Ya-Ling Yeh, Mei-Yi Liao, Ying-Jan Wang
Summary: Immunotherapy is an efficient anticancer strategy that utilizes the host's immune system to fight against cancer cells. Nanotechnology plays a crucial role in enhancing the anticancer effects of immunotherapy by targeting cancer cells and the tumor microenvironment. Autophagy, triggered by nanomaterials, plays a critical role in optimizing immune function and mediating cell-extrinsic homeostatic effects.
Article
Oncology
Wei-Ting Chen, Yuan-Hsin Tsai, Peggy Tan, Fei-Ting Hsu, Hui-Min David Wang, Wei-Chin Lin, Feng-Huei Lin, Ching-Te Wu
Summary: Osteosarcoma is a common bone malignancy with high metastatic characteristics and poor prognosis. Fluoxetine, an anti-depressant, has been shown to have antitumor potential. In this study, fluoxetine was found to induce cytotoxicity and apoptosis in osteosarcoma cells, while also suppressing metastasis and angiogenesis by targeting STAT3.
ANTICANCER RESEARCH
(2023)
Article
Cell Biology
Yu-Chang Liu, Cheng Hsun Lin, Kuan-Tin Chen, De-Wei Lai, Fei-Ting Hsu
Summary: Hepatocellular carcinoma (HCC) is a common cancer in Asian population and is relatively insensitive to radiotherapy (RT). Epidermal growth factor receptor (EGFR)-mediated signalling plays a crucial role in HCC treatment efficacy. 18beta-glycyrrhetinic acid (18 beta-GA) has anti-tumor effects, but its ability to sensitize HCC to RT is unclear. This study used RNA data to analyze the relationship between EGFR/ERK/nuclear factor kappa B (NF-kappa B) signalling and RT and found that NF-kappa B activation may lead to RT resistance in HCC. Combining 18 beta-GA with RT enhanced RT efficacy in a Hep3B-bearing animal model. 18 beta-GA acts as a radiosensitizer by inhibiting EGFR-mediated HCC progression and inducing caspase-dependent apoptosis signalling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Letter
Oncology
Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hsu
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Plant Sciences
Fei-Ting Hsu, Wei-Lin Liu, Sin-Rong Lee, Long-Bin Jeng, Jiann-Hwa Chen
Summary: Researchers have found that magnolol, a compound derived from Magnolia officinalis, shows potential in the treatment of bladder cancer. Through a series of experiments, it was discovered that magnolol can inhibit the development of bladder cancer by activating apoptosis signaling pathways and inhibiting the NF-kappa B pathway. Importantly, magnolol does not exhibit significant toxicity in normal tissues and holds promise as a safe adjunctive therapy.
Meeting Abstract
Oncology
Po-Fu Yueh, Yuan Chang, Keng-Li Lan, Fei-Ting Hsu
Meeting Abstract
Oncology
Peggy Tan, Jai-Jen Tsai, Fei-Ting Hsu, Yu-Chiang Liu
Meeting Abstract
Oncology
Kai-Jen Pai, I-Tsang Chiang, Fei-Ting Hsu, Jai-Jen Tsai
Meeting Abstract
Oncology
Tsal-Lan Liao, I-Tsang Chiang, Yuan Chang, Fei-Ting Hsu
Meeting Abstract
Oncology
Tsai Lin Lo, Jai-Jen Tsai, Fei-Ting Hsu, Yuan Chang
Meeting Abstract
Oncology
Ying-Tzu Chen, I-Tsang Chiang, Yuan Chang, Fei-Ting Hsu
Article
Biochemistry & Molecular Biology
Hsu-Shan Huang, I-Tsang Chiang, Bashir Lawal, Yueh-Shan Weng, Long-Bin Jeng, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu
Summary: A newly developed drug called CC12 has been found to effectively penetrate the blood-brain barrier and possess anti-GBM capacity. It initiates apoptotic mechanisms and disrupts LYN/ERK/STAT3/NF-KB-regulated GBM progression, inhibiting tumor growth and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
