Review
Chemistry, Medicinal
Mohammad Bagherniya, Hamed Khedmatgozar, Omid Fakheran, Suowen Xu, Thomas P. Johnston, Amirhossein Sahebkar
Summary: The NLRP3 inflammasome is a multiprotein complex that is activated by a wide range of danger signals resulting from metabolic dysregulation. Nutraceuticals and medicinal plants have antiinflammatory properties and can be used as complementary therapy in chronic diseases related to inflammation by inhibiting NLRP3 inflammasome activation. Herb-based medicine has shown protective effects against NLRP3 inflammasome activation.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Michaela Komaromyova, Dominika Mravcakova, Daniel Petric, Katarina Kuckova, Michal Babjak, Michaela Urda Dolinska, Alzbeta Konigova, Michaela Mad'arova, Ewa Pruszynska-Oszmalek, Adam Cieslak, Klaudia Cobanova, Zora Varadyova, Marian Varady
Summary: The study found that medicinal plants and organic selenium can improve the performance of infected lambs, aiding in the control of gastrointestinal nematode infection.
Review
Plant Sciences
Andreea Balan, Marius Alexandru Moga, Lorena Dima, Catalina Georgeta Dinu, Carmen Constantina Martinescu, Diana Elena Panait, Claudia Alexandrina Irimie, Costin Vlad Anastasiu
Summary: Endometriosis is a chronic and complex disease affecting young women worldwide, with symptoms such as infertility and pain. Traditional treatments have side effects, while herbal medicines and plant compounds may offer beneficial effects.
Review
Biochemistry & Molecular Biology
Eduardo Antuna, Cristina Cachan-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez
Summary: In a world where life expectancy is increasing, understanding and promoting healthy aging has become a contemporary demand. Inflammaging, a chronic and low-grade systemic inflammation in the elderly, is linked with many age-associated diseases. There are correlations between sarcopenia, the loss of strength and mass in skeletal muscle related to aging, and inflammaging. Inflammatory signals from chronic diseases negatively affect skeletal muscle, and autophagic mechanisms play a role in inflammation. Strategies such as using melatonin or senotherapeutic compounds could counteract inflammation in the muscle. This review aims to present the factors regulating skeletal muscle inflammaging and their implications in sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli, Alessia Cedola
Summary: Neurogenic muscle atrophy is a condition associated with diseases and aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches provide no concrete resolution. Nutritional support could play a relevant part in mitigating neurogenic muscle atrophy.
Article
Biochemistry & Molecular Biology
Luana Tripodi, Davide Molinaro, Francesco Fortunato, Carolina Mella, Barbara Cassani, Yvan Torrente, Andrea Farini
Summary: This study demonstrates that ONX-0914, a selective inhibitor of the PSMB8 subunit of immunoproteasome, improves pathological traits associated with muscle wasting in a mouse model of Duchenne muscular dystrophy. It reduces inflammation, increases regulatory T cells, and buffers oxidative stress, ultimately leading to a decrease in fibrosis. This suggests that ONX-0914 could be a promising therapeutic approach for slowing down muscle mass loss in dystrophic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Most Afia Akhtar
Summary: This article reviews the use of traditional medicinal plants in Bangladesh for the treatment of inflammatory disorders and discusses their anti-inflammatory potential and future research directions. A total of 48 plant species have been reviewed, and the mechanisms, habitats, and anti-inflammatory studies conducted outside of Bangladesh are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Yuan-Yuei Chen, Yi-Lin Chiu, Tung-Wei Kao, Tao-Chun Peng, Hui-Fang Yang, Wei-Liang Chen
Summary: Our study highlights that P3NP, HtrA, and apelin are useful for diagnosis of sarcopenia in the clinical setting.
Review
Physiology
Zineb Bouredji, Anteneh Argaw, Jerome Frenette
Summary: Skeletal muscle, comprising almost half of the body weight, plays vital roles in various functions. It has high plasticity and can adapt to stimuli. Satellite cells and inflammatory cells have important roles in muscle homeostasis, injury, and repair processes. However, uncontrolled recruitment of inflammatory cells or chronic inflammation can lead to muscle atrophy and impairment of function. Muscle atrophy and loss of function occur in both physiological and pathological situations. Recent studies have revealed the molecular mechanisms responsible for muscle atrophy caused by modified mechanical loading, aging, and diseases. The inflammatory process in muscle homeostasis and repair is found to be a double-edged sword. Recent therapeutic approaches for muscle wasting disorders, particularly focusing on the RANK/RANKL/OPG pathway, have been reviewed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: This study found a nonlinear relationship between muscle mass and BMI, and suggested that baseline muscle mass and eFFMI are more reliable predictors of diabetes remission than BMI.
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: The study found a non-linear relationship between muscle mass and BMI, with psoas muscle mass and eFFMI being better predictors of diabetes remission after Roux-en-Y gastric bypass surgery compared to BMI.
Article
Biochemistry & Molecular Biology
Keryn G. Woodman, Chantal A. Coles, Shireen R. Lamande, Jason D. White
Summary: Resveratrol at a lower dosage showed potential efficacy in reducing muscle damage and inflammatory cell markers associated with Duchenne muscular dystrophy, suggesting it as a candidate drug for treating DMD.
Article
Nutrition & Dietetics
Thais C. Borges, Tatyanne LN. Gomes, Claude Pichard, Alessandro Laviano, Gustavo D. Pimentel
Summary: Systemic inflammation measured by NLR was associated with increased sarcopenia risk in hospitalized cancer patients, with NLR ≥ 6.5 group showing higher levels of C-reactive protein, neutrophils, PLR, and SARC-F.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Evelien Van Roie, Charlotte Hiroux, Mathias Vanmunster, Walter Coudyzer, Frank Suhr, Stijn Bogaerts, Ruud Van Thienen, Katrien Koppo
Summary: The study found that while Ω-3 fatty acids contribute to increased muscle strength in older adults, they do not improve beneficial catabolic or inflammatory adaptations induced by resistance exercise. Changes in muscle quality, rather than muscle volume, might explain the gains in strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Oncology
Caroline Joseph Kiriacos, Monika Rafik Khedr, Miray Tadros, Rana A. Youness
Summary: This article introduces some herbal remedies that have potential anticancer activity, immuno-modulatory roles, and promising anti-SARS-CoV-2 actions, with special attention given to matcha as a novel potential protective and therapeutic agent for cancer and immunocompromised patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarina Ataei, Amir Abbas Momtazi-Borojeni, Shiva Ganjali, Maciej Banach, Amirhossein Sahebkar
Summary: This study evaluated the immunogenic potential of a carrier-free peptide-based anti-PCSK9 vaccine in albino mice. The results showed that the vaccine induced a significant production of IgG antibodies and inhibited PCSK9 concentrations and its interaction with LDLR in the blood plasma.
CURRENT MEDICINAL CHEMISTRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maciej Banach, Christopher P. Cannon, Francesco Paneni, Peter E. Penson
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Sajjad Chamani, Omid Kooshkaki, Maryam Moossavi, Mandana Rastegar, Sara Saffar Soflaei, Alice P. McCloskey, Maciej Banach, Amirhossein Sahebkar
Summary: Statins not only lower lipid levels, but also modulate immune cell function and differentiation. Further research is needed to understand the molecular targets of statins in regulating the immune response, given their potential advantages in treating inflammatory and autoimmune disorders.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Adrian V. Hernandez, Vinay Pasupuleti, Nancy Scarpelli, Jack Malespini, Maciej Banach, Agata M. Bielecka-Dabrowa
Summary: This study assessed the benefits and harms of Sacubitril/valsartan (S/V) compared to ACEI or ARB in heart failure patients. The results showed that S/V reduced HF hospitalizations by 20%, CV mortality by 14%, and all-cause mortality by 11% compared to ACEI or ARB. However, S/V had negative effects on renal function and increased hypotension events.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Medicine, General & Internal
Amir Vahedian-Azimi, Farshad Heidari Beni, Zlatko Fras, Maciej Banach, Seyede Momeneh Mohammadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: AKI is a common and severe complication in critically ill patients, with high mortality rates. Statin therapy may have beneficial effects on the disease by reducing mortality rates and overall hospital length of stay. However, the impact of statin treatment on the development of AKI and ICU stay is inconclusive.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Kamila Ryczkowska, Weronika Adach, Kamil Janikowski, Maciej Banach, Agata Bielecka-Dabrowa
Summary: Cardiovascular diseases are common for both men and women, but there are differences in terms of symptoms, pathophysiology, and treatment response. Women often have a lower perception of the risk, leading to delayed diagnosis and recognition of symptoms. The risk of cardiovascular diseases and the importance of monitoring women's health increase after menopause due to the loss of estrogen's protective effect.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Letter
Medicine, General & Internal
Kamal Awad, Carl J. Lavie, Maciej Banach
MAYO CLINIC PROCEEDINGS
(2023)
Article
Clinical Neurology
George Howard, Maciej Banach, Brett Kissela, Mary Cushman, Paul Muntner, Suzanne E. Judd, Virginia J. Howard
Summary: This study assessed the association between stroke risk factors and incident stroke, and evaluated whether the magnitude of this association is uniform across different age groups. The results showed that the associations of hypertension and diabetes with stroke significantly decreased in older age groups, while the associations of smoking, atrial fibrillation, and left ventricular hypertrophy with stroke did not vary with age.
Article
Pharmacology & Pharmacy
Stanislaw Surma, Amirhossein Sahebkar, Maciej Banach
Summary: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation, along with other risk factors such as hypertension, lipid disorders, and diabetes, may contribute to the residual risk of cardiovascular disease (CVD). While modern lipid-lowering treatments are not fully effective in reducing inflammation, selected nutraceuticals with anti-inflammatory properties, including tea and coffee, may have a significant impact on reducing cardiovascular risk and mortality. However, the clinical significance of the anti-inflammatory effects of tea and coffee remains uncertain due to inconsistent results from studies and confounding factors.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Julia Nowak, Roman Jaskulski, Wojciech Kubissa, Bartlomiej Matusiak, Maciej Banach
Summary: This study investigated the strength and thermal properties of concrete with crumb rubber from used tyres replacing part of the aggregate. The results showed a decrease in compressive strength and improved insulation properties with an increase in rubber content. A thermomechanical index was introduced to evaluate the functionality of the concrete, and only three out of twelve series failed to meet the performance requirements.
Review
Cardiac & Cardiovascular Systems
Katarzyna Gryglewska-Wawrzak, Krzysztof Cienkowski, Alicja Cienkowska, Maciej Banach, Agata Bielecka-Dabrowa
Summary: COVID-19 is a severe respiratory syndrome caused by SARS-CoV-2. Heart failure is associated with poor prognosis in COVID-19 patients and can also result from myocardial damage. Understanding the interactions between the disease and viruses is crucial for optimal treatment. Currently, the validity of screening for cardiovascular complications after COVID-19 is uncertain, and individualized diagnosis procedures based on clinical symptoms are recommended. We present a structured approach to COVID-19 patients with heart involvement.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Medicine, General & Internal
Kamal Awad, Maged Mohammed, Seth S. Martin, Maciej Banach
Summary: This study found that electronic nicotine delivery systems (ENDS) use was significantly associated with an increased risk of stroke compared to non-users, while there was no association between former ENDS use and the risk of stroke.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Peripheral Vascular Disease
Maciej Banach, Giuseppe Danilo Norata
Summary: Elevated levels of LDL-C increase the risk of atherosclerotic cardiovascular disease (ASCVD), and reducing LDL-C levels can lower the risk of cardiovascular adverse events. Red yeast rice (RYR) has cholesterol-lowering effects due to its bioactive components (monacolins) that inhibit the activity of HMG-CoA reductase. However, the use of RYR as a food supplement at a dose of 10 mg/day raises significant safety concerns, and serious adverse effects have been reported at even lower doses.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Andy Wai Kan Yeung, Ali Torkamani, Atul J. Butte, Benjamin S. Glicksberg, Bjorn Schuller, Blanca Rodriguez, Daniel S. W. Ting, David Bates, Eva Schaden, Hanchuan Peng, Harald Willschke, Jeroen van der Laak, Josip Car, Kazem Rahimi, Leo Anthony Celi, Maciej Banach, Maria Kletecka-Pulker, Oliver Kimberger, Roland Eils, Sheikh Mohammed Shariful Islam, Stephen T. Wong, Tien Yin Wong, Wei Gao, Soren Brunak, Atanas G. Atanasov
Summary: This narrative review discusses the current use and future strategies of digital health technologies in modern healthcare applications. It outlines the strengths, limitations, and applications of the scientific field and predicts the future impact of emerging key technologies. Additionally, recommendations are provided to accelerate and benefit the research, translation, and utilization of digital health technologies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Alexandr Ceasovschih, Victorita Sorodoc, Annabelle Shor, Raluca Ecaterina Haliga, Lynn Roth, Catalina Lionte, Viviana Onofrei Aursulesei, Oana Sirbu, Nicolae Culis, Albina Shapieva, Mohammed A. R. Tahir Khokhar, Cristian Statescu, Radu A. Sascau, Adorata Elena Coman, Alexandra Stoica, Elena-Daniela Grigorescu, Maciej Banach, Costas Thomopoulos, Laurentiu Sorodoc
Summary: The COVID-19 pandemic, which started in Wuhan, China, in early 2020, has caused a global health crisis. The disease mainly affects the respiratory system but can also have an impact on other systems, including the cardiovascular system. The relationship between atherosclerosis and COVID-19 is bidirectional, with both conditions exacerbating each other. The pandemic has also led to reduced access to healthcare amenities, an increase in sedentary lifestyles and unhealthy eating habits, resulting in a high prevalence of overweight and obese individuals. The long-term healthcare challenges posed by COVID-19 can be mitigated by the lessons learned and the advancements made in patient care during this crisis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)