Article
Biochemistry & Molecular Biology
Zhou Jingyang, Che Jinhui, Xu Lu, Yang Weizhong, Li Yunjiu, Wang Haihong, Zhou Wuyuan
Summary: miR-320b suppressed pancreatic cancer cell proliferation by targeting FOXM1, providing a potential new diagnostic marker for pancreatic cancer.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Reproductive Biology
Sifan Sun, Hailiang Fang
Summary: This study demonstrated that curcumin inhibits ovarian cancer cell proliferation and promotes apoptosis by regulating the circ-PLEKHM3/miR-320a/SMG1 axis. This suggests a potential therapeutic role of curcumin in ovarian cancer through mediating the circRNA/miRNA/mRNA network.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wenqing Sun, Yan Li, Dongyu Ma, Yi Liu, Qi Xu, Demin Cheng, Guanru Li, Chunhui Ni
Summary: The study finds that ALKBH5 promotes silica-induced lung fibrosis through the miR-320a-3p/FOXM1 axis or direct targeting of FOXM1. Inhibition of ALKBH5 may be effective in treating lung fibrosis.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Ling Qi, Weiyao Wang, Guifang Zhao, Hong Jiang, Yu Zhang, Donghai Zhao, Hong Jin, Haiyang Xu, Hongquan Yu
Summary: The study revealed that circCCDC66 acts as an oncogene in glioma by promoting cell proliferation, invasion and migration. CircCCDC66 was found to down-regulate miR-320a and up-regulate FOXM1, which in turn regulates multiple cancer-related pathways involved in DNA damage response. This suggests circCCDC66 may play a key role in glioma progression.
Article
Oncology
Jun Liu, Jianwen Zhao, Guang Feng, Rui Li, Jianhang Jiao
Summary: This study explores the role of circ-CDK14 in the progression of osteosarcoma. The results show that silencing circ-CDK14 can inhibit proliferation, migration, and invasion of osteosarcoma cells and promote apoptosis. In addition, circ-CDK14 regulates the progression of osteosarcoma cells by targeting the miR-198/E2F2 axis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Haitao Wei, Li Li, Haifeng Zhang, Feng Xu, Longqi Chen, Guowei Che, Yun Wang
Summary: The study revealed that circ-FOXM1 is upregulated in NSCLC and can affect the proliferation, migration, and apoptosis of lung cancer cells by modulating the miR-149-5p/ATG5 axis.
Article
Orthopedics
Rui Hu, Shan Chen, Jianxin Yan
Summary: Circ-CNST plays a role in OS progression by upregulating LDHA and PDK1 while downregulating miR-578, leading to increased cell proliferation, colony formation, migration, and invasion. Blocking circ-CNST and restoring miR-578 can reverse these effects, offering a potential therapeutic target for OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Oncology
Yali Yu, Guixiang Dong, Zijun Li, Yan Zheng, Zhisong Shi, Guanghui Wang
Summary: This study discovered that circ-LRP6 inhibits the proliferation, migration, and invasion of osteosarcoma cells by regulating the miR-141-3p/HDAC4/HMGB1 axis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Pei Xu, Lei Wang, Qingtao Liu, Pengkai Gao, Fengqing Hu, Xiao Xie, Lianyong Jiang, Rui Bi, Fangbao Ding, Qi Yang, Haibo Xiao
Summary: This study found that circ-ARAP2 is upregulated in ESCC and promotes ESCC progression through regulating the miR-761/FOXM1 axis-mediated stemness and EMT.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xinli Dong, Yanhua Wang, Hua Zhuang, Gang An
Summary: This study investigated the therapeutic effect of Hydroxygenkwanin (HGK) on osteosarcoma and its specific molecular mechanism. The findings suggest that HGK inhibits proliferation, migration, and invasion of MG-63 and U2OS cells through the miR-320a/SOX9 axis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Jie Gao, Chengzhi Ding, Junhui Zhou, Gang Wu, Zongmao Han, Jianchao Li, Feilong Hei
Summary: Propofol inhibited lung cancer progression by mediating the circ-ERBB2/miR-7-5p/FOXM1 axis, providing a potential effective therapeutic target for lung cancer treatment.
Article
Pathology
Elahe Abdollahi, Hossein Mozdarani
Summary: Assessing the radiosensitivity of cells can help select appropriate treatment regimens and minimize adverse effects in breast cancer patients. The study found that circ-HIPK3 and circ-PVT1 may serve as promising biomarkers for predicting breast cancer and cellular radiosensitivity.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kankui Wu, Xiaowei Wang, Huiming Yu, Zhifen Yu, Dazhao Wang, Xiaohong Xu
Summary: Our study demonstrated that LINC00460 promotes TSCC progression through the miR-320b/IGF2BP3 axis, suggesting a potential therapeutic target for TSCC treatment.
Article
Immunology
Alicia Gonzalez-Martinez, Gauruv Bose, Hrishikesh Lokhande, Shrishti Saxena, Brian C. Healy, Mariann Polgar-Turcsanyi, Howard L. Weiner, Tanuja Chitnis
Summary: miR-320b and miR-25-3p expression are early biomarkers associated with MS severity and brain atrophy. This study suggests that miR-320b and miR-25-3p may serve as potential indicators for early diagnosis and treatment decisions in multiple sclerosis.
JOURNAL OF NEUROINFLAMMATION
(2023)