Journal
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
Volume 15, Issue 5, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793545822500328
Keywords
Surface-enhanced Raman spectroscopy (SERS); serum; liver cancer; multivariate analysis
Funding
- National Natural Science Foundation of China [61775037]
- Natural Science Foundation of Fujian Province of China [2019J01270]
- Special Funds of the Central Government Guiding Local Science and Technology Development [2020L3008]
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In this study, the feasibility of using serum surface-enhanced Raman spectroscopy (SERS) to identify liver cancer was investigated. The differences between pre-operation and post-operation SERS spectra of liver cancer patients were analyzed. The results showed the potential of SERS spectroscopy in early diagnosis of liver cancer.
Early diagnosis of liver cancer plays a significant role in reducing its high mortality. In this preliminary study, the feasibility of using serum surface-enhanced Raman spectroscopy (SERS) to identify liver cancer was studied. Serum samples were obtained from liver cancer patients and healthy controls. The differences between the SERS spectra of pre-operation and post-operation of liver cancer patients were also analyzed. The general shape and trend of SERS spectra of health control and liver cancer patients were similar. Multivariate analysis, e.g., PLS-SVM, might be useful for the discrimination of serum SERS spectra of pre-operation and post-operation.
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