Article
Behavioral Sciences
Marie Lindvik Jorstad, Morgan Scarth, Svenn Torgersen, Harrison Graham Pope, Astrid Bjornebekk
Summary: This study found that personality disorders and clinical psychiatric syndromes are common among users of anabolic-androgenic steroids. The study identified four distinct psychopathology subgroups among AAS users, highlighting the importance of considering individual psychiatric profiles when providing treatment to this population.
BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Morgan Scarth, Lars T. Westlye, Ingrid A. Havnes, Astrid Bjornebekk
Summary: This study aimed to understand AAS dependence and muscle dysmorphia symptoms using network analyses. The most central symptoms in the AAS dependence network were continuing use despite side effects, using longer than planned, tolerance, and work/life interference. When comparing AAS users and controls, exercise dependence and size/symmetry concerns were the most central symptoms in muscle dysmorphia. There were no significant connections between AAS dependence and muscle dysmorphia symptoms.
Article
Psychiatry
Barnaby N. Zoob Carter, Ian D. Boardley, Katinka van de Ven
Summary: The study found that the COVID-19 pandemic had an impact on the training and anabolic-androgenic steroid (AAS) use of strength athletes, particularly in terms of reduced training frequency and AAS dose. However, the short-term mental health consequences of the pandemic on training and AAS use did not appear to have long-lasting effects.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Cardiac & Cardiovascular Systems
Kahtan Fadah, Gokul Gopi, Ajay Lingireddy, Vanessa Blumer, Tracy Dewald, Robert J. Mentz
Summary: Synthetic steroids have a negative impact on the heart, leading to cardiomyopathy and heart failure. While some treatments exist, further research is needed to understand the long-term effects and potential therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Aditi Sharma, Bonnie Grant, Heraa Islam, Aditi Kapoor, Anjali Pradeep, Channa N. Jayasena
Summary: AAS misuse is prevalent, especially among young men, and withdrawal symptoms can be distressing. Effective therapies are needed to support AAS withdrawal.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychiatry
Razieh Chegeni, Guy Notelaers, Stale Pallesen, Dominic Sagoe
Summary: The study utilized MLCA to classify AAS users into subgroups of aggression and distress, identifying five distinct patterns. While a homogenous model was best for both sexes, gender significantly influenced subgroup membership probabilities. The findings suggest unique profiles of aggression and psychological distress among male and female AAS users.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Peter Bond, Diederik L. Smit, Willem de Ronde
Summary: This review provides a comprehensive overview of the working mechanism and potential side effects of anabolic-androgenic steroids (AAS). It discusses the absorption and transportation of AAS in the body and highlights the importance of understanding treatment options and self-medication practices for AAS users.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Morgan Scarth, Marie Lindvik Jorstad, Amund Reierstad, Sandra Klonteig, Svenn Torgersen, Ingunn R. Hullstein, Astrid Bjornebekk
Summary: Females who use anabolic-androgenic steroids (AAS) generally experience increased levels of psychopathology compared to weight-lifting controls (WLC). These include externalizing personality disorders, such as borderline, antisocial, and sadistic, as well as depressive, negativistic, and masochistic personality disorders. The study also found that all clinical syndromes were elevated among AAS users, with 56% of them meeting the clinical criteria for six or more disorders. These findings highlight the importance of recognizing and addressing the challenges in providing care for this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Medicine, Legal
Nawal Izzat, Rana Abu-Farha, Mea'ad M. Harahsheh, Samar Thiab
Summary: This study aims to assess the intentions, perceptions, and safety of anabolic-androgenic steroid (AAS) use among Jordanian gym users. The findings reveal that the desire to compete in bodybuilding contests is the primary motivation for AAS use. Gym coaches are an important source of information for users, but there is a lack of awareness about the side effects and health risks associated with AAS. To address this issue, structured awareness campaigns should be conducted, and sports governing bodies should implement stricter measures to discourage AAS use among athletes.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Substance Abuse
Tjeerd Idger de Zeeuw, Tibor Markus Brunt, Jan van Amsterdam, Katinka van de Ven, Wim van den Brink
Summary: This study aimed to determine whether patterns of AAS use and other variables are associated with the presence of AASUD. The results showed that the probability of moderate-severe AASUD increases with the duration and average dose of AAS use. This indicates that moderate-severe AASUD is relatively frequent among male AAS consumers and is positively associated with the duration and dose of AAS use in the last 12 months.
EUROPEAN ADDICTION RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Ana Petrovic, Sonja Vukadin, Renata Sikora, Kristina Bojanic, Robert Smolic, Davor Plavec, George Y. Wu, Martina Smolic
Summary: Anabolic androgenic steroids have therapeutic benefits but are commonly misused and have detrimental effects on various organs, particularly the liver. This article reviews the latest knowledge on the adverse effects of anabolic androgenic steroids on the liver and their mechanisms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Health Care Sciences & Services
Giuseppe Davide Albano, Francesco Amico, Giuseppe Cocimano, Aldo Liberto, Francesca Maglietta, Massimiliano Esposito, Giuseppe Li Rosi, Nunzio Di Nunno, Monica Salerno, Angelo Montana
Summary: AASs are widely used molecules that enhance muscle growth and athletic performance, but also come with systemic side effects, particularly impacting the cardiovascular and reproductive systems. Preventive measures such as improving healthcare worker knowledge, standardized diagnostic tests, and educational interventions are essential to mitigate the negative effects of AAS abuse.
Article
Sport Sciences
Shalender Bhasin, Disa L. Hatfield, Jay R. Hoffman, William J. Kraemer, Michele Labotz, Stuart M. Phillips, Nicholas A. Ratamess
Summary: This consensus statement acknowledges the lawful and ethical therapeutic use of anabolic-androgenic steroids (AAS) but condemns the illicit use of AAS for enhancing performance and appearance, especially among competitive athletes. It updates the science behind how AAS work metabolically/biochemically, discusses potential side effects, prevalence of use among athletes, and AAS use in clinical scenarios.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Jon J. Rasmussen, Caroline Kistorp
Summary: Abuse of anabolic-androgenic steroids (AAS) is associated with reduced fibrin clot lysis, likely due to increased plasma concentrations of fibrinogen, FXIII, and plasmin inhibitor, rather than alterations in fibrin structure. This suggests a potential link between AAS abuse and increased thrombotic disease risk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Substance Abuse
Ingrid Amalia Havnes, Marie Lindvik Jorstad, Ingveig Innerdal, Astrid Bjornebekk
Summary: This study explored how women with current or previous anabolic-androgenic steroids (AAS) use experience and process masculinizing effects. The majority of women were introduced to AAS and advised on usage by a trusted male partner, friend, or coach. Most were unprepared for unwanted masculinizing effects, some of which they found outweighed the desired effects.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Oncology
Bjornar Hassel, Pitt Niehusmann, Bente Halvorsen, Daniel Dahlberg
Summary: This study quantitatively analyzed leukocyte markers and cytokines in the cyst fluid of cystic glioblastomas and found that their concentrations were higher compared to brain abscess pus, indicating a highly pro-inflammatory environment. Furthermore, the study revealed an important interaction between cystic glioblastomas and the circulation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Daniel Dahlberg, Jutta Rummel, Sonia Distante, Gustavo Antonio De Souza, Maria Ekman Stensland, Espen Mariussen, Helge Rootwelt, Oyvind Voie, Bjornar Hassel
Summary: The cyst fluid of cystic glioblastomas contains various hormones, which may originate from the circulation, the tumor, or the brain tissue. The wide variation in hormone concentrations in the fluid may have differential effects on tumor growth.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Clinical Neurology
Ahmed Jamali, Erle Kristensen, Trine Tangeraas, Vibeke Arntsen, Alma Sikiric, Guste Kupliauskiene, Sverre Myren-Svelstad, Siren Berland, Yngve Sejersted, Thorsten Gerstner, Bjornar Hassel, Laurence A. Bindoff, Eylert Brodtkorb
Summary: This study aimed to assess the spectrum of PDE at various ages in Norway. The results showed a higher prevalence of PDE-ALDH7A1 in children, highlighting the importance of early diagnosis.
Article
Psychology, Educational
Goril Brevik Svae, Bjornar Hassel, Erik Sondenaa
Summary: This study aimed to identify barriers to preventing harmful sexual behaviour in people with intellectual disabilities within the support sector and the justice system. The study found that a lack of education and guidelines was a major challenge in regulating the sexual behaviour of people with intellectual disabilities.
JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES
(2023)
Article
Medicine, General & Internal
Ane Rogne, Bjornar Hassel
Summary: This case report suggests that moderately reduced serum levels of free testosterone may contribute to the ADHD symptoms of some adult male patients, and testosterone treatment may be beneficial for these patients.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Psychiatry
Emilie S. M. Kildal, Daniel S. Quintana, Attila Szabo, Christian Tronstad, Ole Andreassen, Terje Naerland, Bjornar Hassel
Summary: This study aims to use heart rate monitoring to identify potentially painful care procedures for non-communicative patients with autism and intellectual disability. It also aims to assess the effect of HR-informed changes in care procedures on biomarkers of pain and the quality of communication between patients and caregivers through HR.
Article
Rehabilitation
Tone Oderud, Elin S. Boysen, Frode Strisland, Inger-Lise Dahl, Emilie Kildal, Bjornar Hassel, Cecilie Morland
Summary: This study explores how professional caregivers and parents identify pain and distress in non-verbal persons with severe intellectual disability (ID), and their attitudes towards using wearable sensors for detection. The results indicate that current methods of observation and behavioral signs are insufficient, and caregivers and parents are positive about using wearable sensors as long as user autonomy and privacy are not compromised.
TECHNOLOGY AND DISABILITY
(2023)
Article
Medicine, Research & Experimental
Leiv Otto Watne, Christian Thomas Pollmann, Bjorn Erik Neerland, Else Quist-Paulsen, Nathalie Bodd Halaas, Ane-Victoria Idland, Bjornar Hassel, Kristi Henjum, Anne-Brita Knapskog, Frede Frihagen, Johan Raeder, Aasmund Godo, Per Magne Ueland, Adrian McCann, Wender Figved, Geir Selbaek, Henrik Zetterberg, Evandro F. Fang, Marius Myrstad, Lasse M. Gill
Summary: This study found that in patients with delirium, the concentration of the neurotoxic metabolite quinolinic acid in the cerebrospinal fluid (CSF-QA) was increased and was associated with neuronal damage markers and 1-year mortality. This discovery reveals a strong link between systemic inflammation, neurotoxicity, and delirium.
JOURNAL OF CLINICAL INVESTIGATION
(2023)