Dietary and Nutrient Patterns and Brain MRI Biomarkers in Dementia-Free Adults

Cognitive impairment is a rapidly growing public health problem. As there is no curative treatment for dementia, the proactive management of modifiable risk factors and the identification of early biomarkers indicative of the cognitive decline are of great importance. Although nutrition is one of the most extensively studied lifestyle factor in relation to cognitive health, its association with brain magnetic resonance imaging (MRI) biomarkers is not well established. In the present work, we review available studies relating dietary or nutrient patterns with brain MRI biomarkers in dementia-free adults. Greater adherence to the Mediterranean diet has been associated with the preservation of structural connectivity and less brain atrophy in adults without dementia. In addition, specific nutrient patterns, characterized by a high intake of antioxidant vitamins, polyphenols and unsaturated fatty acids, have been related to larger brain volume. Although the results are encouraging regarding the role of dietary and nutrient patterns on imaging biomarkers, more well-designed observational longitudinal studies and clinical trials are needed in order to confirm potentially causal relationships and better understand underlying mechanisms.

Automated summary

Cognitive impairment is a growing public health problem and proactive management of modifiable risk factors and early identification of biomarkers are important. Studies have shown that adherence to the Mediterranean diet and specific nutrient patterns are associated with preserved brain connectivity, reduced brain atrophy, and larger brain volume in adults without dementia. However, more well-designed studies are needed to confirm causal relationships and understand underlying mechanisms.