Journal
CANCER DISCOVERY
Volume 12, Issue 9, Pages 2026-2030Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-22-0703
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The confirmation of the HER2-low paradigm is expected to have a major impact on breast oncology, leading to significant changes in treatment algorithms and posing challenges in interpretation and diagnosis.
The confirmation of the HER2-low paradigm is expected to have a major impact in breast oncology. About half of all breast cancers harbor HER2-low expression, which can be targeted with the anti-HER2 anti-body-drug conjugate trastuzumab deruxtecan (T-DXd), leading to a relevant survival benefit in the metastatic setting. Given this observation, treatment algorithms for both hormone receptor-positive and triple-negative breast cancer are expected to significantly evolve in the next future. Several challenges, however, remain in the interpretation of HER2-low expression related to its biological role, its pathologic diagnosis, and the definition itself of HER2-low. In this article, we recapitulate the current knowledge on HER2-low breast cancer, discussing whether it should be considered a distinct subtype, how it should be implemented in the clinic, and how its defini-tion may evolve in the coming years with the evolution of our clinical and translational knowledge.
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