Journal
ACS CATALYSIS
Volume 12, Issue 14, Pages 8380-8385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c02090
Keywords
chiral Suzuki-Miyaura; enzymatic kinetic resolution; high-throughput experimentation; atropisomer; biaryls; hydrolase
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We report an unprecedented chiral Suzuki-Miyaura/enzymatic kinetic resolution sequence for the synthesis of atropisomeric biaryls yielding the targets in high enantiopurity without chiral separation.
Axially chiral biaryl fragments are recurrent scaffolds in drugs. These essential synthons are often built via metal catalyzed Csp2-Csp2 bond formation and subsequent separation of the atropisomers, resulting in low yields and excess waste. Asymmetric variants have been reported, unfortunately without reaching the optical purity desired for active pharmaceutical ingredients. Additional enantioenriching steps are therefore required, but even if efficient, these methods generate waste and are often problematic on scale. Herein, we report an unprecedented chiral Suzuki-Miyaura/enzymatic kinetic resolution sequence for the synthesis of JNJ-4355 and other atropisomeric biaryls yielding the targets in high enantiopurity without chiral separation.
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