Ligand-induced transmembrane conformational coupling in monomeric EGFR

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

(2020) J. H. Lorent et al.   Nature Chemical Biology

Direct measurements of VEGF:VEGFR2 binding affinities reveal the coupling between ligand binding and receptor dimerization

(2019) Christopher King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity

(2019) Michael D. Paul et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Single-Molecule Fluorescence Detection of the Epidermal Growth Factor Receptor in Membrane Discs

(2018) Steven D. Quinn et al.   BIOCHEMISTRY

Lipid-Protein Interplay in Dimerization of Juxtamembrane Domains of Epidermal Growth Factor Receptor

(2018) Ryo Maeda et al.   BIOPHYSICAL JOURNAL

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

(2018) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

(2018) Samantha I. Liang et al.   Cell Reports

The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers

(2018) Laura C. Zanetti-Domingues et al.   Nature Communications

Single-molecule spectroscopy of LHCSR1 protein dynamics identifies two distinct states responsible for multi-timescale photosynthetic photoprotection

(2017) Toru Kondo et al.   Nature Chemistry

EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

(2016) Mohammed Kaplan et al.   CELL

Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the Epidermal Growth Factor Receptor (EGFR) and HER3 Receptor Tyrosine Kinases

(2016) Theodore R. Keppel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Changes in the Epidermal Growth Factor Receptor: Role of the Transmembrane Domain Investigated by Coarse-Grained MetaDynamics Free Energy Calculations

(2016) Mickaël Lelimousin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

(2016) Sarah R. Needham et al.   Nature Communications

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

(2016) Yongjian Huang et al.   eLife

Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea

(2016) Sara Barberán et al.   Scientific Reports

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

The Membrane Mimetic Affects the Spatial Structure and Mobility of EGFR Transmembrane and Juxtamembrane Domains

(2015) Konstantin S. Mineev et al.   BIOCHEMISTRY

Interactions of the EGFR juxtamembrane domain with PIP 2 -containing lipid bilayers: Insights from multiscale molecular dynamics simulations

(2015) Khairul Bariyyah Abd Halim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Growth Factor Identity Is Encoded by Discrete Coiled-Coil Rotamers in the EGFR Juxtamembrane Region

(2015) Amy Doerner et al.   CHEMISTRY & BIOLOGY

CHARMM-GUI Martini Maker for Coarse-Grained Simulations with the Martini Force Field

(2015) Yifei Qi et al.   Journal of Chemical Theory and Computation

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   MOLECULAR AND CELLULAR BIOLOGY

Electrostatics, structure prediction, and the energy landscapes for protein folding and binding

(2015) Min-Yeh Tsai et al.   PROTEIN SCIENCE

Cell-free expression of functional receptor tyrosine kinases

(2015) Wei He et al.   Scientific Reports

Balanced Protein–Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association

(2014) Robert B. Best et al.   Journal of Chemical Theory and Computation

Tracking Single Particles on Supported Lipid Membranes: Multimobility Diffusion and Nanoscopic Confinement

(2014) Chia-Lung Hsieh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor

(2014) Nicholas J. Bessman et al.   Cell Reports

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Structure and function of epigen, the last EGFR ligand

(2013) Marlon R. Schneider et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Finding the missing links in EGFR

(2012) Nicholas J Bessman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Consequences of replacing EGFR juxtamembrane domain with an unstructured sequence

(2012) Lijuan He et al.   Scientific Reports

Development of SNAP-Tag Fluorogenic Probes for Wash-Free Fluorescence Imaging

(2011) Xiaoli Sun et al.   CHEMBIOCHEM

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Watching conformational- and photodynamics of single fluorescent proteins in solution

(2010) Randall H. Goldsmith et al.   Nature Chemistry

Characterizing diffusion dynamics of a membrane protein associated with nanolipoproteins using fluorescence correlation spectroscopy

(2010) Tingjuan Gao et al.   PROTEIN SCIENCE

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

(2009) Markus Almén et al.   BMC BIOLOGY

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Orientation and dynamics of transmembrane peptides: the power of simple models

(2009) Andrea Holt et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ligand-induced ErbB receptor dimerization

(2008) Mark A. Lemmon   EXPERIMENTAL CELL RESEARCH

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS