Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-32205-3
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Funding
- LINCS-BD2K Data Coordination and Integration Center U54 grant [U54HL127624]
- Computational Tool Development and Integrative Data Analysis for LINCS U01 grant [U01HL111638]
- Center for Environmental Genetics Bioinformatics Core: [P30ES006096]
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iLINCS is an integrative web-based platform that integrates multiple omics data types and analysis tools for the analysis and visualization of cellular perturbations and omics data. Its user-friendly interface enables users to perform complex omics signatures analysis and drug repositioning.
There are only a few platforms that integrate multiple omics data types, bioinformatics tools, and interfaces for integrative analyses and visualization that do not require programming skills. Here we present iLINCS (http://ilincs.org), an integrative web-based platform for analysis of omics data and signatures of cellular perturbations. The platform facilitates mining and re-analysis of the large collection of omics datasets (>34,000), pre-computed signatures (>200,000), and their connections, as well as the analysis of user-submitted omics signatures of diseases and cellular perturbations. iLINCS analysis workflows integrate vast omics data resources and a range of analytics and interactive visualization tools into a comprehensive platform for analysis of omics signatures. iLINCS user-friendly interfaces enable execution of sophisticated analyses of omics signatures, mechanism of action analysis, and signature-driven drug repositioning. We illustrate the utility of iLINCS with three use cases involving analysis of cancer proteogenomic signatures, COVID 19 transcriptomic signatures and mTOR signaling.
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