Article
Cell Biology
Man Tong, Tin-Lok Wong, Hongzhi Zhao, Yuanyuan Zheng, Yu-Nong Xie, Cheuk-Hin Li, Lei Zhou, Noelia Che, Jing-Ping Yun, Kwan Man, Terence Kin-Wah Lee, Zongwei Cai, Stephanie Ma
Summary: The study identified a loss of tyrosine catabolism and an increase in serum tyrosine levels during liver cancer development. Liver cells with disordered tyrosine catabolism displayed augmented tumorigenic and proliferative potentials. There is a metabolic link between tyrosine and glutamine metabolism, which could be explored as a potential anticancer therapy for liver cancer.
Article
Environmental Sciences
Linchen He, Xinyan Hu, Drew B. Day, Meilin Yan, Yanbo Teng, Xing (Lucy) Liu, Erik Yan, Jianbang Xiang, Xinghua Qiu, Jinhan Mo, Yinping Zhang, Junfeng (Jim) Zhang, Jicheng Gong
Summary: Exposure to certain nitro-PAHs may affect glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Julio Jose Jimenez-Alonso, Emilio Guillen-Mancina, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: Sulfur-containing amino acids methionine (Met), cysteine (Cys), and taurine (Tau) play important roles in cellular functions and metabolism. This study investigates the role of Cys and Tau in the anticancer activity of Met-restricted diets. The results show that diets supplemented with Cys or Tau exhibit marked anticancer activity in animal models of colon cancer, ovarian cancer, and renal cell carcinoma. These findings suggest the potential use of these diets in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Abdelrahim Alqudah, Mohammed Wedyan, Esam Qnais, Hassan Jawarneh, Lana McClements
Summary: The study found changes in the levels of certain amino acids in patients with type 2 diabetes, with some essential amino acids increased and some non-essential amino acids decreased. These amino acids were shown to be correlated with the patients' blood glucose and HbA1c levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jones Gyamfi, Jinyoung Kim, Junjeong Choi
Summary: Cancer is not only a genetic disease but also a result of metabolic dysregulation. Metabolic alterations in cancer cells, including key changes in glucose, glutamine, and fatty acid metabolism, are more common among different subtypes and types of cancer. Recognizing cancer as a metabolic disorder can reveal important diagnostic and treatment markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Summary: It was found that deficiency of Ppm1k leads to reduced metabolism of branched-chain amino acids (BCAAs) and protects against obesity-induced glucose intolerance. Accumulation of branched-chain keto acids (BCKAs) inhibits glucose production in liver cells. It was observed that BCKAs suppress the activity of liver mitochondrial pyruvate carrier (MPC) and pyruvate-supported respiration. Selective suppression of pyruvate-supported gluconeogenesis was seen in Ppm1k-deficient mice and could be restored through pharmacological activation of BCKA catabolism by BT2. Furthermore, liver MPC was found to be most sensitive to circulating BCKA levels, making it a sensor of BCAA metabolism.
Article
Medicine, Research & Experimental
Arnaud Germain, Ludovic Giloteaux, Geoffrey E. Moore, Susan M. Levine, John K. Chia, Betsy A. Keller, Jared Stevens, Carl J. Franconi, Xiangling Mao, Dikoma C. Shungu, Andrew Grimson, Maureen R. Hanson
Summary: Post-exertional malaise (PEM) is a prominent symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). By monitoring plasma metabolites, this study found significant differences in metabolic response and recovery pattern between ME/CFS patients and healthy control participants after two maximal exercise tests. Glutamate metabolism was identified as a crucial factor in the metabolic disruptions that lead to PEM.
Review
Oncology
Ahmad Ali, Ugo Chianese, Chiara Papulino, Antonella Toraldo, Mawada Elmagboul Abdalla Abakar, Eugenia Passaro, Rosario Cennamo, Nunzio Del Gaudio, Lucia Altucci, Rosaria Benedetti
Summary: This article describes the metabolic features of pancreatic ductal adenocarcinoma and discusses how this could be exploited as a weakness for clinical interventions. Metabolism plays a crucial role in the development of PDAC, and interventions on bioenergetic circuits could potentially reduce its aggressiveness.
Review
Oncology
Oliver Abrahamsen, Eva Balslev, Estrid Hogdall
Summary: Cancer cells increase metabolic activity to meet their energy demands, leading to a need for building materials like glucose and amino acids. Investigating the supply lines of these materials in the blood may offer therapeutic opportunities targeting the thermodynamic foundation of cancer. Understanding how these metabolic supply lines affect survival and metastasis in cancer patients could provide insights for potential interventions.
ANTICANCER RESEARCH
(2021)
Review
Medicine, Research & Experimental
Xi-Zi Zhu, Zhi-Min Deng, Fang-Fang Dai, Hua Liu, Yan-Xiang Cheng
Summary: Miscarriage is the most common complication of pregnancy with various causes, including chromosomal abnormalities, endocrine disorders, organ malformations, immune factors, and metabolic abnormalities. The roles of glucose, lipid, amino acid metabolism, and oxidation-reduction balance, along with metabolism-related genes, in miscarriage are discussed. While hormonal and immunological drugs, as well as surgery, are currently used for miscarriage treatment, there are limited therapies for metabolism-related factors. Therefore, the study of altered metabolism in miscarriage not only helps in understanding the mechanisms but also contributes to the development of new therapies.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Marc-Olivier Deguise, Lucia Chehade, Rashmi Kothary
Summary: Spinal muscular atrophy (SMA) is a genetic disorder causing paralysis, muscle atrophy, and death. Recent research suggests that gastrointestinal, metabolic, and endocrine defects may contribute to the disease phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Julio Jose Jimenez-Alonso, Emilio Guillen-Mancina, Jose Manuel Calderon-Montano, Victor Jimenez-Gonzalez, Patricia Diaz-Ortega, Estefania Burgos-Moron, Miguel Lopez-Lazaro
Summary: The study evaluated the therapeutic potential of selective amino acid restriction in colon cancer and found that artificial diets based on this restriction can improve survival rates.
Article
Biochemistry & Molecular Biology
Qian Ji, Hengchao Li, Zhiwei Cai, Xiao Yuan, Xi Pu, Yumeng Huang, Shengqiao Fu, Liangmei Chu, Chongyi Jiang, Junli Xue, Xiaoxin Zhang, Rongkun Li
Summary: Bioinformatics analyses identified glycogen phosphorylase L (PYGL) as a key regulator of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC). PYGL overexpression promotes PDAC cell migration and invasion, while PYGL knockdown has opposite effects. Hypoxia induces PYGL expression in a HIF1 alpha-dependent manner and regulates glycogen accumulation to fuel glycolysis, thereby inducing the EMT process. Clinically, elevated PYGL expression is associated with poor prognosis in PDAC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
D. N. Coleman, P. Totakul, N. Onjai-uea, A. Aboragah, Q. Jiang, M. Vailati-Riboni, R. T. Pate, D. Luchini, P. Paengkoum, M. Wanapat, F. C. Cardoso, J. J. Loor
Summary: This study investigates the effects of rumen-protected Methionine during a heat stress challenge on hepatic abundance of mTOR, insulin, and antioxidant signaling proteins, as well as enzymes in 1-carbon metabolism and innate immunity in dairy cows. The results suggest that feeding rumen-protected Methionine may help cows maintain homeostasis in mTOR, insulin signaling, and 1-carbon metabolism, as well as whole-blood antioxidant response during heat stress, which is crucial for innate immune function.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Endocrinology & Metabolism
Sarah L. Armour, Jade E. Stanley, James Cantley, E. Danielle Dean, Jakob G. Knudsen
Summary: Glucagon and its producing cells, pancreatic islet alpha cells, have remained enigmatic in relation to insulin-producing beta cells. However, recent data suggest a more holistic model of metabolic signaling, involving the regulation of multiple nutrients and reciprocal feedback to regulate glucagon secretion and alpha cell mass.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sebastian Kjaergaard, Thorbjorn S. R. Jensen, Ulrike R. Feddersen, Niels Bindslev, Kaare Grunddal, Steen S. Poulsen, Hanne B. Rasmussen, Esben Budtz-Jorgensen, Mark Berner-Hansen
Summary: Patients with quiescent ulcerative colitis have a relatively low number of colonic tuft cells compared to controls. Further studies are needed to investigate the potential involvement of tuft cells in the pathogenesis of ulcerative colitis.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Clara Amalie Gade Timmermann, Marianne Skovsager Andersen, Esben Budtz-Jorgensen, Henriette Boye, Flemming Nielsen, Richard Christian Jensen, Signe Bruun, Steffen Husby, Philippe Grandjean, Tina Kold Jensen
Summary: This study found a positive association between increased serum-PFAS concentrations during early pregnancy and an increased risk of terminating breastfeeding after childbirth. However, there was no correlation between serum-PFAS concentrations and serum-prolactin concentrations. These findings are of public health importance given the global exposures to PFAS and the long-term health consequences they may have on breastfeeding ability.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Public, Environmental & Occupational Health
Philippe Grandjean, Howard Hu, Christine Till, Rivka Green, Morteza Bashash, David Flora, Martha Maria Tellez-Rojo, Peter X. K. Song, Bruce Lanphear, Esben Budtz-Jorgensen
Summary: This study used benchmark dose modeling to analyze data from two prospective birth cohort studies. Results showed an association between maternal urinary fluoride concentrations during pregnancy and children's IQ, with boys showing lower benchmark concentrations than girls. The study found a BMCL of approximately 0.2 mg/L for adjusted urinary fluoride concentrations in pregnant women, providing guidance for preventing excess fluoride exposure.
Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Esben Budtz-Jorgensen, Thomas Gerds
Summary: The study confirmed a decreased response to antidepressants in patients with depression and comorbid epilepsy, especially among younger and unemployed patients. This emphasizes the importance of close monitoring and psychological support for these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Statistics & Probability
Brice Ozenne, Esben Budtz-Jorgensen, Sebastian Elgaard Ebert
Summary: This article introduces the use of the max-test procedure in latent variable models for multiple testing. The effectiveness of the procedure for Wald and Score tests in LVMs is evaluated through simulation studies. The procedure is then applied to quantify the neuroinflammatory response to mild traumatic brain injury in multiple brain regions.
COMPUTATIONAL STATISTICS
(2023)
Article
Clinical Neurology
Marie N. N. Hellem, Rachel Y. Cheong, Simone Tonetto, Tua Vinther-Jensen, Rebecca K. Hendel, Ida U. Larsen, Troels T. Nielsen, Lena E. Hjermind, Asmus Vogel, Esben Budtz-Jorgensen, Asa Petersen, Jorgen E. Nielsen
Summary: This study is the first to measure oxytocin levels in the cerebrospinal fluid (CSF) of Huntington's disease gene expansion carriers (HDGECs). The study found that HDGECs have significantly lower levels of oxytocin compared to controls, and there is a correlation between oxytocin levels and social cognition. These findings suggest that oxytocin could be an objective and comparable biomarker for impaired social cognition in HD, and further treatment trials are recommended to evaluate the potential effect of oxytocin on social cognition in HD.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Thomas Gerds, Esben Budtz-Jorgensen
Summary: This nationwide population-based longitudinal register linkage study aimed to investigate the long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy. The study also aimed to compare differences in responses between lithium, valproate, and lamotrigine within patients with comorbid bipolar disorder and epilepsy. The findings suggest that valproate and lamotrigine should be given priority in these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Eva Bolling-Ladegaard, Julie Werenberg Dreier, Lars Vedel Kessing, Esben Budtz-Jorgensen, Kasper Lolk, Jakob Christensen
Summary: This study investigates the magnitude and long-term association between epilepsy and depression, comparing with the risks of the 2 disorders after another chronic medical illness (asthma). Results show a long-term bidirectional relationship between depression and epilepsy, with higher risk estimates than for epilepsy or depression after asthma.
Article
Environmental Sciences
Esben Budtz-Jorgensen, Philippe Grandjean
Summary: By analyzing two data sets using the BMD method, the study found that using different dose-response models can lead to more accurate results. The toxicity of different PFAS was compared, confirming differences in toxicity among them. It was concluded that EFSA's proposed tolerable exposure limit is too high, while the EPA's proposal is more in line with the research results.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Marie Pedersen, Shuo Liu, Jiawei Zhang, Zorana Jovanovic Andersen, Jorgen Brandt, Esben Budtz-Jorgensen, Klaus Bonnelykke, Lise Marie Frohn, Anne-Marie Nybo Andersen, Matthias Ketzel, Jibran Khan, Leslie Stayner, Bert Brunekreef, Steffen Loft
Summary: This study found that early-life exposure to ambient air pollution increases the risk of childhood asthma.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Endocrinology & Metabolism
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Anders Sjodin, Mads F. F. Hjorth, Arne Astrup, Esben Budtz-Jorgensen
Summary: The objective of this study was to test the association between perfluorinated alkylate substance (PFAS) exposures and body weight increases in a dietary intervention study. The results showed that elevated plasma concentrations of PFOA and PFHxS were significantly associated with increased weight gain, exceeding the effects of different diet groups. The findings suggest that obesogenic PFASs may contribute to the obesity pandemic.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jack J. J. Xu, Lars Loenn, Esben Budtz-Jorgensen, Samir Jawad, Peter S. S. Ulriksen, Kristoffer L. L. Hansen
Summary: This study compared the noise, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and image quality of deep-learning image reconstruction (DLIR) vs. adaptive statistical iterative reconstruction (ASIR-V) in gray scale 74 keV virtual monoenergetic (VM) abdominal dual-energy CT (DECT) with different slice thicknesses. The results showed that DLIR significantly reduced image noise, increased CNR and SNR, and improved image quality, especially in 0.625 mm slice images, compared to ASIR-V.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jack Junchi Xu, Lars Lonn, Esben Budtz-Jorgensen, Kristoffer L. Hansen, Peter S. Ulriksen
Summary: The study demonstrates that DLIR significantly reduces image noise compared to ASIR-V in DECT image reconstruction, with significant improvements in certain measurements. Additionally, qualitative assessment shows substantial enhancement in image quality with DLIR, especially in thin sliced images.
EUROPEAN RADIOLOGY
(2022)
Meeting Abstract
Clinical Neurology
Eva Bolling-Ladegaard, Julie Dreier, Lars V. Kessing, Esben Budtz-Jorgensen, Jakob Christensen