A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir

Novel Nitrile Peptidomimetics for Treating COVID-19

(2022) C. S. Brian Chia   ACS Medicinal Chemistry Letters

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

(2021) Cheng Liu et al.   ANTIVIRAL RESEARCH

A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors

(2021) Subramanyam Vankadara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents

(2021) Sho Konno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors

(2021) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A tale of two antiviral targets — and the COVID-19 drugs that bind them

(2021) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

(2021) Dafydd R. Owen et al.   SCIENCE

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

(2021) Britton Boras et al.   Nature Communications

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics

(2020) Arun K. Ghosh et al.   ChemMedChem

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

(2020) Chunlong Ma et al.   CELL RESEARCH

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients

(2020) Christian Gampe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential SARS-CoV-2 main protease inhibitors

(2020) Riddhidev Banerjee et al.   DRUG DISCOVERY TODAY

Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery

(2019) Nenad Manevski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

(2018) Wint Wint Phoo et al.   ANTIVIRAL RESEARCH

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease

(2016) Yong Wah Tan et al.   Scientific Reports

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study

(2015) Melgious J. Y. Ang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease

(2015) Yangyang Zhai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: A P1–P4 SAR study

(2013) Melgious Jin Yan Ang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

(2013) Pillaiyar Thanigaimalai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: A P3 and N-cap optimization study

(2013) Huichang Annie Lim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel therapies for hepatitis C — one pill fits all?

(2013) Michael P. Manns et al.   NATURE REVIEWS DRUG DISCOVERY

Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

(2012) Chi-Pang Chuck et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

(2011) Lili Zhu et al.   ANTIVIRAL RESEARCH