Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium

A Model of Human Small Airway on a Chip for Studies of Subacute Effects of Inhalation Toxicants

(2022) Courtney Sakolish et al.   TOXICOLOGICAL SCIENCES

Characterizing the Reproducibility in Using a Liver Microphysiological System for Assaying Drug Toxicity, Metabolism and Accumulation

(2021) Andres Rubiano et al.   CTS-Clinical and Translational Science

3D Cell Culture Models: Drug Pharmacokinetics, Safety Assessment, and Regulatory Consideration

(2021) Hongbing Wang et al.   CTS-Clinical and Translational Science

Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs

(2021) Jong Hwan Sung   Expert Opinion on Drug Metabolism & Toxicology

Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development

(2021) Passley Hargrove-Grimes et al.   CELLS TISSUES ORGANS

Applicability of organ-on-chip systems in toxicology and pharmacology

(2021) Marlon R. Schneider et al.   CRITICAL REVIEWS IN TOXICOLOGY

Human microphysiological systems for drug development

(2021) Adrian Roth et al.   SCIENCE

Prediction of Hepatic Drug Clearance with a Human Microfluidic Four-Cell Liver Acinus MicroPhysiology System

(2021) Courtney Sakolish et al.   TOXICOLOGY

Putting Science into Standards workshop on standards for organ-on-chip

(2021) Monica Piergiovanni et al.   Stem Cell Reports

Emerging technologies and their impact on regulatory science

(2021) Elke Anklam et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Adoption of organ-on-chip platforms by the pharmaceutical industry

(2021) Paul Vulto et al.   NATURE REVIEWS DRUG DISCOVERY

The Future of Uncertainty Factors With In Vitro Studies Using Human Cells

(2021) Michael Dourson et al.   TOXICOLOGICAL SCIENCES

Update and Evaluation of a High-Throughput In Vitro Mass Balance Distribution Model: IV-MBM EQP v2.0

(2021) James M. Armitage et al.   Toxics

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Opportunities and challenges with microphysiological systems: a pharma end-user perspective

(2020) Lorna Ewart et al.   NATURE REVIEWS DRUG DISCOVERY

A next generation risk assessment case study for coumarin in cosmetic products

(2020) M T Baltazar et al.   TOXICOLOGICAL SCIENCES

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)

(2020) Amy M. Avila et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Interstitial flow regulates in vitro three-dimensional self-organized brain micro-vessels

(2020) Agathe Figarol et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

(2020) Yizhong Liu et al.   TOXICOLOGY

Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)

(2020) Courtney Sakolish et al.   TOXICOLOGY

Development of an in vitro approach to point-of-contact inhalation toxicity testing of volatile compounds, using organotypic culture and air-liquid interface exposure

(2020) Artik Mistry et al.   TOXICOLOGY IN VITRO

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

(2019) Russell S Thomas et al.   TOXICOLOGICAL SCIENCES

Impact of organ-on-a-chip technology on pharmaceutical R&D costs

(2019) Nora Franzen et al.   DRUG DISCOVERY TODAY

Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data

(2019) Kirsten Rasmussen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs

(2019) Courtney Sakolish et al.   TOXICOLOGICAL SCIENCES

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling

(2019) Courtney Sakolish et al.   TOXICOLOGY IN VITRO

In Vitro Research Reproducibility: Keeping Up High Standards

(2019) Cordula Hirsch et al.   Frontiers in Pharmacology

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

(2018) Lorna Ewart et al.   Annual Review of Pharmacology and Toxicology

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

3S - Systematic, systemic, and systems biology and toxicology

(2018) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

(2018) Anna Bal-Price   ALTEX-Alternatives to Animal Experimentation

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

(2018) Courtney Sakolish et al.   Scientific Reports

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals

(2018) Helen Prior et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Organs-on-chips: Progress, challenges, and future directions

(2017) Lucie A Low et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

(2017) Antony J. Williams et al.   Journal of Cheminformatics

The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

(2016) Ila Cote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The FAIR Guiding Principles for scientific data management and stewardship

(2016) Mark D. Wilkinson et al.   Scientific Data

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public–private partnerships

(2016) Christine A. Livingston et al.   Computational and Structural Biotechnology Journal

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Developing microphysiological systems for use as regulatory tools – challenges and opportunities

(2014) Melvin E. Andersen   ALTEX-Alternatives to Animal Experimentation

Regulatory advice and drug development-A case study in negotiating with regulators

(2011) Jørgen Seldrup   STATISTICS IN MEDICINE