Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines

Tumor vascular biomarkers: New opportunities for cancer diagnostics1

(2017) Chunsheng Li et al.   Cancer Biomarkers

Nano-graphene oxide-mediated In vivo fluorescence imaging and bimodal photodynamic and photothermal destruction of tumors

(2016) Poliraju Kalluru et al.   BIOMATERIALS

Pegylated folate and peptide-decorated graphene oxide nanovehicle for in vivo targeted delivery of anticancer drugs and therapeutic self-monitoring

(2016) Jiangwei Tian et al.   BIOSENSORS & BIOELECTRONICS

One-pot synthesis of dextran decorated reduced graphene oxide nanoparticles for targeted photo-chemotherapy

(2016) Yanfang Hu et al.   CARBOHYDRATE POLYMERS

Carboxymethyl chitosan-mediated synthesis of hyaluronic acid-targeted graphene oxide for cancer drug delivery

(2016) Huihui Yang et al.   CARBOHYDRATE POLYMERS

Graphene oxide-wrapped PEGylated liquid crystalline nanoparticles for effective chemo-photothermal therapy of metastatic prostate cancer cells

(2016) Raj Kumar Thapa et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide

(2016) Xin Ting Zheng et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

In vitro and in vivo brain-targeting chemo-photothermal therapy using graphene oxide conjugated with transferrin for Gliomas

(2016) Haixin Dong et al.   LASERS IN MEDICAL SCIENCE

Targeted delivery and controlled release of doxorubicin into cancer cells using a multifunctional graphene oxide

(2016) Yao Lv et al.   Materials Science & Engineering C-Materials for Biological Applications

Targeted, triggered drug delivery to tumor and biofilm microenvironments

(2016) Danielle SW Benoit et al.   Nanomedicine

Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity

(2016) Ligeng Xu et al.   Nanoscale

Monitoring of the tumor response to nano-graphene oxide-mediated photothermal/photodynamic therapy by diffusion-weighted and BOLD MRI

(2016) Jianbo Cao et al.   Nanoscale

Evaluation of the toxicity of graphene oxide exposure to the eye

(2016) Wei Wu et al.   Nanotoxicology

pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment

(2016) Zuhong Li et al.   Small

Fabrication of Graphene and AuNP Core Polyaniline Shell Nanocomposites as Multifunctional Theranostic Platforms for SERS Real-time Monitoring and Chemo-photothermal Therapy

(2016) Haolin Chen et al.   Theranostics

Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics

(2016) Dehong Hu et al.   Theranostics

Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies

(2016) Christopher B. Howard et al.   Advanced Healthcare Materials

Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier

(2015) Zhiyuan Xu et al.   ACS Applied Materials & Interfaces

Photothermal Therapeutic Response of Cancer Cells to Aptamer–Gold Nanoparticle-Hybridized Graphene Oxide under NIR Illumination

(2015) Lingyan Yang et al.   ACS Applied Materials & Interfaces

Development of a Graphene Oxide Nanocarrier for Dual-Drug Chemo-phototherapy to Overcome Drug Resistance in Cancer

(2015) Tuan Hiep Tran et al.   ACS Applied Materials & Interfaces

Endoperoxides Revealed as Origin of the Toxicity of Graphene Oxide

(2015) Hanna Pieper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biotin-Containing Reduced Graphene Oxide-Based Nanosystem as a Multieffect Anticancer Agent: Combining Hyperthermia with Targeted Chemotherapy

(2015) Nicolò Mauro et al.   BIOMACROMOLECULES

VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo

(2015) Sixiang Shi et al.   BIOMATERIALS

Radionuclide 131I labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer

(2015) Lei Chen et al.   BIOMATERIALS

Targeting the tumor vasculature to enhance T cell activity

(2015) Evripidis Lanitis et al.   CURRENT OPINION IN IMMUNOLOGY

Graphene Oxide-Based Nanocarriers for Cancer Imaging and Drug Delivery

(2015) Peihong You et al.   CURRENT PHARMACEUTICAL DESIGN

Accumulation and toxicity of intravenously-injected functionalized graphene oxide in mice

(2015) Kai-Ping Wen et al.   JOURNAL OF APPLIED TOXICOLOGY

Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy

(2015) Peng Huang et al.   Journal of Biomedical Nanotechnology

Methotrexate-conjugated quantum dots: synthesis, characterisation and cytotoxicity in drug resistant cancer cells

(2015) Mohammad Johari-Ahar et al.   JOURNAL OF DRUG TARGETING

Self-degrading niosomes for encapsulation of hydrophilic and hydrophobic drugs: An efficient carrier for cancer multi-drug delivery

(2015) Varsha Sharma et al.   Materials Science & Engineering C-Materials for Biological Applications

Hydrous RuO2nanoparticles as an efficient NIR-light induced photothermal agent for ablation of cancer cells in vitro and in vivo

(2015) Zhiyin Xiao et al.   Nanoscale

Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer

(2015) Hui Ding et al.   Nanoscale

Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer

(2015) Lin Hou et al.   NANOTECHNOLOGY

Formulation, characterization, and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles

(2015) Morteza Eskandani et al.   PHARMACEUTICAL BIOLOGY

Graphene oxide selectively targets cancer stem cells, across multiple tumor types: Implications for non-toxic cancer treatment, via “differentiation-based nano-therapy”

(2015) Marco Fiorillo et al.   Oncotarget

Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

(2015) Jaleh Barar et al.   JOURNAL OF NANOBIOTECHNOLOGY

One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery

(2014) Jingqin Chen et al.   BIOMATERIALS

Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier

(2014) Ting Zhou et al.   BIOMATERIALS

Cancer nanomedicine and the complement system activation paradigm: Anaphylaxis and tumour growth

(2014) S.M. Moghimi   JOURNAL OF CONTROLLED RELEASE

Immune response is required for the control of in vivo translocation and chronic toxicity of graphene oxide

(2014) Qiuli Wu et al.   Nanoscale

Molecular signals regulating translocation and toxicity of graphene oxide in the nematode Caenorhabditis elegans

(2014) Qiuli Wu et al.   Nanoscale

NIR photoregulated chemo- and photodynamic cancer therapy based on conjugated polyelectrolyte–drug conjugate encapsulated upconversion nanoparticles

(2014) Youyong Yuan et al.   Nanoscale

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Polyethylene Glycol (PEG) Linked to Near Infrared (NIR) Dyes Conjugated to Chimeric Anti-Carcinoembryonic Antigen (CEA) Antibody Enhances Imaging of Liver Metastases in a Nude-Mouse Model of Human Colon Cancer

(2014) Ali A. Maawy et al.   PLoS One

Ligand-targeted particulate nanomedicines undergoing clinical evaluation: Current status

(2013) Roy van der Meel et al.   ADVANCED DRUG DELIVERY REVIEWS

Clinical Application of Drug Delivery Systems in Cancer Chemotherapy: Review of the Efficacy and Side Effects of Approved Drugs

(2013) Takuya Iwamoto   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The antifungal activity of graphene oxide–silver nanocomposites

(2013) Chao Li et al.   BIOMATERIALS

Tumor vasculature targeting and imaging in living mice with reduced graphene oxide

(2013) Sixiang Shi et al.   BIOMATERIALS

Graphene-based magnetic plasmonic nanocomposite for dual bioimaging and photothermal therapy

(2013) Xiaoze Shi et al.   BIOMATERIALS

Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy

(2013) Abhishek Sahu et al.   BIOMATERIALS

Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy

(2013) Zonghai Sheng et al.   BIOMATERIALS

A review of optical imaging and therapy using nanosized graphene and graphene oxide

(2013) Jing-Liang Li et al.   BIOMATERIALS

Graphene oxide covalently grafted upconversion nanoparticles for combined NIR mediated imaging and photothermal/photodynamic cancer therapy

(2013) Yinghui Wang et al.   BIOMATERIALS

Safety and tumor tissue accumulation of pegylated graphene oxide nanosheets for co-delivery of anticancer drug and photosensitizer

(2013) Wenjun Miao et al.   BIOMATERIALS

Tamoxifen loaded folic acid armed PEGylated magnetic nanoparticles for targeted imaging and therapy of cancer

(2013) Mostafa Heidari Majd et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

(2013) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Specific targeting of cancer cells by multifunctional mitoxantrone-conjugated magnetic nanoparticles

(2013) Mostafa Heidari Majd et al.   JOURNAL OF DRUG TARGETING

Multifunctional Mesoporous Silica-Coated Graphene Nanosheet Used for Chemo-Photothermal Synergistic Targeted Therapy of Glioma

(2013) Yi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo optical-resolution photoacoustic computed tomography with compressed sensing

(2013) Jing Meng et al.   OPTICS LETTERS

Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery

(2013) Liangzhu Feng et al.   Small

In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene

(2012) Hao Hong et al.   ACS Nano

Ultrasmall Gold Nanoparticles Anchored to Graphene and Enhanced Photothermal Effects by Laser Irradiation of Gold Nanostructures in Graphene Oxide Solutions

(2012) Abdallah F. Zedan et al.   ACS Nano

PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer’s Disease

(2012) Davide Brambilla et al.   ACS Nano

Nanoparticle and targeted systems for cancer therapy

(2012) Lisa Brannon-Peppas et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

(2012) Zhenjiang Zhang et al.   ADVANCED MATERIALS

In vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-graphene

(2012) Hao Hong et al.   BIOMATERIALS

Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumors

(2012) Bart Cornelissen et al.   BIOMATERIALS

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

Nontoxic concentrations of PEGylated graphene nanoribbons for selective cancer cell imaging and photothermal therapy

(2012) Omid Akhavan et al.   JOURNAL OF MATERIALS CHEMISTRY

The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy

(2012) Omid Akhavan et al.   JOURNAL OF MATERIALS CHEMISTRY

Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy

(2012) X.C. Qin et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Low Band Gap Donor-Acceptor Conjugated Polymer Nanoparticles and their NIR-mediated Thermal Ablation of Cancer Cells

(2012) Christopher M. MacNeill et al.   MACROMOLECULAR BIOSCIENCE

A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging

(2012) Xinxing Ma et al.   Nano Research

Hybrid gold–gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo

(2012) De-Hong Hu et al.   Nanoscale

Purified Graphene Oxide Dispersions Lack In Vitro Cytotoxicity and In Vivo Pathogenicity

(2012) Hanene Ali-Boucetta et al.   Advanced Healthcare Materials

Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts

(2011) Ken-Hsuan Liao et al.   ACS Applied Materials & Interfaces

Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide

(2011) Bo Tian et al.   ACS Nano

Theranostic Nanoshells: Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy (Adv. Mater. 45/2011)

(2011) Wenjie Dong et al.   ADVANCED MATERIALS

Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide

(2011) Wen Zhang et al.   BIOMATERIALS

The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power

(2011) Kai Yang et al.   BIOMATERIALS

Colorimetric platform for visual detection of cancer biomarker based on intrinsic peroxidase activity of graphene oxide

(2011) Fengli Qu et al.   BIOSENSORS & BIOELECTRONICS

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

(2011) Vanesa C. Sanchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Phase II study of a cremophor-free, polymeric micelle formulation of paclitaxel for patients with advanced urothelial cancer previously treated with gemcitabine and platinum

(2011) Jae-Lyun Lee et al.   INVESTIGATIONAL NEW DRUGS

Impact of albumin on drug delivery — New applications on the horizon

(2011) Bakheet Elsadek et al.   JOURNAL OF CONTROLLED RELEASE

Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

(2011) Joshua T. Robinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

(2011) Georgy Mikhaylov et al.   Nature Nanotechnology

Chitosan-Functionalized Graphene Oxide as a Nanocarrier for Drug and Gene Delivery

(2011) Hongqian Bao et al.   Small

Synthesis of hexagonal close-packed gold nanostructures

(2011) Xiao Huang et al.   Nature Communications

Exfoliation of Graphite Oxide in Propylene Carbonate and Thermal Reduction of the Resulting Graphene Oxide Platelets

(2010) Yanwu Zhu et al.   ACS Nano

Magnetic and Acoustically Active Lipospheres for Magnetically Targeted Nucleic Acid Delivery

(2010) Dialechti Vlaskou et al.   ADVANCED FUNCTIONAL MATERIALS

In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes

(2010) Zoran M. Markovic et al.   BIOMATERIALS

Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors

(2010) Xiaowen Liu et al.   BIOMATERIALS

Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting

(2010) Adam J. Cole et al.   BIOMATERIALS

Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy

(2010) Kai Yang et al.   NANO LETTERS

High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes

(2010) Joshua T. Robinson et al.   Nano Research

Multifunctional nanocomposites of superparamagnetic (Fe3O4) and NIR-responsive rare earth-doped up-conversion fluorescent (NaYF4 : Yb,Er) nanoparticles and their applications in biolabeling and fluorescent imaging of cancer cells

(2010) Congcong Mi et al.   Nanoscale

Section-illumination photoacoustic microscopy for dynamic 3D imaging of microcirculation in vivo

(2010) Liang Song et al.   OPTICS LETTERS

High-Photoluminescence-Yield Gold Nanocubes: For Cell Imaging and Photothermal Therapy

(2009) Xi Wu et al.   ACS Nano

Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes

(2009) Supratim Ghosh et al.   ACS Nano

Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices

(2009) Andres W. Martinez et al.   ANALYTICAL CHEMISTRY

Prostate-Specific Antigen Is a “Chymotrypsin-like” Serine Protease with Unique P1 Substrate Specificity†

(2009) Aaron M. LeBeau et al.   BIOCHEMISTRY

Fast and Facile Preparation of Graphene Oxide and Reduced Graphene Oxide Nanoplatelets

(2009) Jianfeng Shen et al.   CHEMISTRY OF MATERIALS

High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array

(2009) Liang Song et al.   MEDICAL PHYSICS

Gold nanocages covered by smart polymers for controlled release with near-infrared light

(2009) Mustafa S. Yavuz et al.   NATURE MATERIALS

Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs

(2009) Liming Zhang et al.   Small

In Situ Amplified Electrochemical Immunoassay for Carcinoembryonic Antigen Using Horseradish Peroxidase-Encapsulated Nanogold Hollow Microspheres as Labels

(2008) Dianping Tang et al.   ANALYTICAL CHEMISTRY

Paper-Based Bioassays Using Gold Nanoparticle Colorimetric Probes

(2008) Weian Zhao et al.   ANALYTICAL CHEMISTRY

Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

(2008) Erin B. Dickerson et al.   CANCER LETTERS

PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs

(2008) Zhuang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nano-graphene oxide for cellular imaging and drug delivery

(2008) Xiaoming Sun et al.   Nano Research

Microarray Analysis of the Toxicogenomics and the Genotoxic Potential of a Cationic Lipid-Based Gene Delivery Nanosystem in Human Alveolar Epithelial A549 Cells

(2008) Yadollah Omidi et al.   TOXICOLOGY MECHANISMS AND METHODS

Synthesis of amphiphilic graphite oxide

(2007) Chao Xu et al.   CARBON