Article
Engineering, Multidisciplinary
Mohammad Javed Ansari, Mohammed F. Aldawsari, Ameeduzzafar Zafar, Alireza Soltani, Mohd Yasir, Mohammed Asadullah Jahangir, Mohamad Taleuzzaman, Vahid Erfani-Moghadam, Leila Daneshmandi, Nosrat O. Mahmoodi, Asieh Yahyazadeh, Md Lutfor Rahman, Mohd Sani Sarjadi
Summary: Two different nanoformulations, LTSP micellar/liposomal and TSP micellar/niosomal, were prepared using the thin-film hydration method. These nanoformulations showed potential for delivering SSZ, improving its bioavailability, and exhibited increased cell toxicity.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Nastassja Burrini, Mario D'Ambrosio, Matteo Gentili, Roberta Giaquinto, Veronica Settimelli, Cristina Luceri, Marzia Cirri, Oscar Francesconi
Summary: In this study, an amphiphilic analogue of a mannose receptor was developed and used to functionalize niosomes for the encapsulation of doxorubicin. These functionalized niosomes showed high stability, efficient encapsulation of doxorubicin, and enhanced cytotoxicity towards triple-negative breast cancer cells with overexpressed high-mannose-type glycans. Additionally, the niosomal formulation reduced doxorubicin-induced cytotoxicity towards normal cell lines. This study provides a foundation for further in vivo investigations on the antitumoral activity and pharmacokinetics of the developed active targeted drug delivery system.
Review
Nanoscience & Nanotechnology
Yuehong Ren, Linghui Nie, Shiping Zhu, Xingwang Zhang
Summary: This article explores the significance of oral drug delivery and the role of nanovesicles in enhancing bioavailability. The study discusses the classification, preparative processes, intestinal transport mechanisms, in vivo fate, and design rationale of nanovesicles. By encapsulating drugs in nanoscale vesicles, the efficiency of oral drug delivery can be greatly improved.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Saman Yasamineh, Pooneh Yasamineh, Hesam Ghafouri Kalajahi, Omid Gholizadeh, Zahra Yekanipour, Hamed Afkhami, Majid Eslami, Amir Hossein Kheirkhah, Milad Taghizadeh, Yalda Yazdani, Mehdi Dadashpour
Summary: Niosomes, formed by the accumulation of nonionic surfactants in water, play a critical role in medication delivery systems. They enable controlled release and targeted distribution, making them suitable for treating cancer, infectious illnesses, and other disorders. Niosomes can also be injected through ocular and transdermal routes. Furthermore, they offer exciting opportunities for manufacturing biotechnology goods and novel vaccines.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biophysics
Shuang Fu, Yinan Zhao, Jiao Sun, Ting Yang, Defu Zhi, Enxia Zhang, Fangli Zhong, Yuhong Zhen, Shufen Zhang, Shubiao Zhang
Summary: RGD-modified liposomes showed excellent active targeting ability for integrin ?v?3 receptors and enhanced DOX release due to their pH-sensitivity, resulting in significant antitumor efficacy with low toxicity. This new approach provides a potential avenue for improved tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Oncology
Maryam Moghtaderi, Kamand Sedaghatnia, Mahsa Bourbour, Mahdi Fatemizadeh, Zahra Salehi Moghaddam, Faranak Hejabi, Fatemeh Heidari, Sameer Quazi, Bahareh Farasati Far
Summary: Nanotechnology has become increasingly important in the field of medicine, especially in the areas of drug delivery and diagnosis. Niosomes, polymeric nanoparticles, show promising potential as drug carriers due to their biocompatibility, high absorption, and ability to deliver both hydrophilic and lipophilic drugs. In this review, the characteristics of niosome vesicles were examined and in silico tools for designing and optimizing these nanoparticles were explained. The use of niosomes for delivering anticancer drugs was compared and discussed as a suitable model for designing therapeutic strategies.
Article
Chemistry, Multidisciplinary
Syed Sarim Imam, Sultan Alshehri, Mohammad A. Altamimi, Afzal Hussain, Khaled Hamad Alyahya, Wael A. Mahdi, Wajhul Qamar
Summary: Luteolin-loaded nanovesicles were successfully prepared using the solvent evaporation method, showing nanometric size, optimum polydispersibility index, and negative zeta potential. These nanovesicles exhibited enhanced drug release and permeation properties, with significant variations in encapsulation efficiency depending on the composition. The antioxidant activity of LT-NVs was superior to pure luteolin, and cytotoxicity studies showed a lower IC50 value, suggesting their potential as a natural alternative for lung cancer treatment.
Article
Chemistry, Medicinal
Huiting Chen, Zhou Fang, Mengdi Song, Kehai Liu
Summary: The study presents a hierarchical drug delivery system, HA-GDT-Lip, which exhibits high cell uptake efficiency and mitochondrial targeting ability, inducing cell apoptosis and showing excellent antitumor activity and in vivo safety.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Bwalya A. Witika, Kokoette E. Bassey, Patrick H. Demana, Xavier Siwe-Noundou, Madan S. Poka
Summary: This review provides a comprehensive summary of the research on niosomes, including their preparation methods, characteristics, and applications in drug delivery. Niosomes, as a type of nanocarrier, have shown great potential for effective drug delivery and offer advantages over liposomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Gan Jiang, Chenxuan Wei, Yaoxing Chen, Yingqi Lyu, Jialin Huang, Hongzhuan Chen, Xiaoling Gao
Summary: This passage discusses the process of macropinocytosis, which allows for the internalization of greater quantities of drugs and is a promising avenue for drug delivery. It also introduces various drug delivery systems that utilize macropinocytosis as the primary internalization mechanism. The potential importance of this field lies in its ability to greatly increase the efficiency and specificity of drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Wenzhao Han, Junfeng Ke, Feng Guo, Fanwei Meng, Hui Li, Liping Wang
Summary: An innovative nano-drug delivery system was designed to efficiently release drugs in the tumor microenvironment, showing low cytotoxicity and promising anti-tumor properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Made Budiarta, Sathi Roy, Tobias Katenkamp, Neus Feliu, Tobias Beck
Summary: Due to its pharmacological properties, ferritin (Ftn) is used as a drug delivery vehicle to reduce the cardiotoxicity of doxorubicin (DOX) in chemotherapy. However, DOX encapsulation in Ftn faces challenges such as precipitation and low protein recovery yield. A new strategy using cysteine-maleimide conjugation for DOX encapsulation in Ftn is proposed and shown to be more efficient. The surface charges of Ftn variants affect the cytotoxicity, DOX loading, and cellular uptake mechanism.
Article
Polymer Science
Erhan Demirel, Yasemin Yuksel Durmaz
Summary: Combination therapy involving anticancer drugs and gene therapy agents has been proven effective in treating different types of cancer. In this study, a modified strategy was developed to enhance the use of reduced graphene oxide (rGO) as a carrier for delivering drugs and nucleotides. The newly designed copolymer allowed for the conjugation of a targeting peptide and the loading of hydrophobic drugs, resulting in a multifunctional nanoplatform with controlled drug release and high transfection efficiency. The experiments demonstrated the potential of this nanoplatform in selectively delivering different cargoes to tumor sites.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Sudipta Mallick, Ramadan Abouomar, David Rivas, Max Sokolich, Fatma Ceren Kirmizitas, Aditya Dutta, Sambeeta Das
Summary: Micro-sized magnetic particles, known as microrobots, have shown potential for biomedical applications such as drug delivery and cell manipulation. This study used microrobots to deliver anticancer drugs to cancer cells, resulting in cell death. The findings confirm the promise of microrobots as precise couriers for targeted delivery of therapeutic biomolecules for cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Chunlei Wu, Zhehong Cheng, Danyi Lu, Ke Liu, Yulian Cheng, Pengxin Wang, Yimin Zhou, Meiqing Li, Ximing Shao, Hongchang Li, Wu Su, Lijing Fang
Summary: Researchers discovered a simplified analogue of Coibamide A and designed two novel peptide-drug conjugates, with one showing better drug release in vitro and significant tumor growth suppression in mice-bearing human tumor xenografts, indicating great potential in cancer drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Instruments & Instrumentation
Jasmin Monpara, Divya Velga, Tripti Verma, Sanjay Gupta, Pradeep Vavia
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2019)
Article
Chemistry, Medicinal
Mrunal Patil, Shashir Wanjare, Vivek Borse, Rohit Srivastava, Preeti Mehta, Pradeep Vavia
ARCHIV DER PHARMAZIE
(2020)
Article
Pharmacology & Pharmacy
Mayank R. Patel, Dimitrios A. Lamprou, Pradeep R. Vavia
Article
Pharmacology & Pharmacy
Nisha Yadav, Jacinth Rajendra, Anagha Acharekar, Shilpee Dutt, Pradeep Vavia
Article
Pharmacology & Pharmacy
V. G. Sita, Pradeep Vavia
Article
Pharmacology & Pharmacy
Pankaj Jadhav, Vinod Gokarna, Vineeta Deshpande, Pradeep Vavia
Article
Pharmacology & Pharmacy
Ketan Mahajan, Satish Rojekar, Dipen Desai, Smita Kulkarni, Gandhali Bapat, Smita Zinjarde, Pradeep Vavia
Summary: Novel hyaluronic acid-coated nanostructured lipid carriers targeting CD44 receptors have been developed for delivery of efavirenz to macrophages in HIV infection. The carriers exhibited good uptake in THP-1 cells, prolonged drug release, and significantly higher inhibition of p24 antigen compared to plain carriers. These findings suggest that CD44 receptor targeting with HA-based carriers is a promising strategy for improving drug delivery to macrophages and achieving effective viral inhibition.
Article
Pharmacology & Pharmacy
Ganesh Shevalkar, Manoj Pawar, Pradeep Vavia
Summary: The study aimed to improve the oral administration of lumefantrine by using nanostructured lipid carriers (NLCs), which showed promising results for oral drug delivery of lumefantrine and drugs with similar properties.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Pharmacology & Pharmacy
Nitin Jadhav, Manoj A. Pawar, Pradeep R. Vavia
Summary: This study reports a Pickering dry emulsion (PDE) system for improved oral delivery of fenofibrate. The PDE system, using modified silica nanoparticles as stabilizers, showed high drug loading and significant enhancement in drug release, leading to improved bioavailability. The study demonstrates the potential of the PDE system in drug delivery.
Article
Pharmacology & Pharmacy
Manoj A. Pawar, Ganesh B. Shevalkar, Pradeep R. Vavia
Summary: This study aimed to develop a gastro-retentive floating tablet of TZN, which demonstrated good in vivo gastric retention and stability after optimization of formulation variables. The floating gastro-retentive system could be a viable alternative to the innovator formulation.
Article
Pharmacology & Pharmacy
Satish Rojekar, Leila Fotooh Abadi, Rohan Pai, Mahendra Kumar Prajapati, Smita Kulkarni, Pradeep R. Vavia
Summary: The present investigation focuses on developing and exploring mannosylated lipid-based carriers for delivering anti-HIV drug and selenium nanoparticles to HIV reservoirs. The results demonstrate that the mannosylated nanostructured lipid carriers have improved therapeutic effectiveness against HIV and significantly increase the therapeutic index. The nano selenium also shows protective effects against oxidative stress in rats.
Review
Pharmacology & Pharmacy
Ankita N. Yawalkar, Manoj A. Pawar, Pradeep R. Vavia
Summary: Microspheres, with their biocompatibility, biodegradability, and surface modifications, are widely explored as drug carriers for targeted and sustained delivery of various drugs to specific sites in the body.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ketan Mahajan, Satish Rojekar, Dipen Desai, Smita Kulkarni, Pradeep Vavia
Summary: The development of cationic EFV-NLCs showed high encapsulation efficiency, uniform particle size distribution, good colloidal stability, and excellent cytocompatibility. Fluorescence microscopy and flow cytometry confirmed efficient uptake and superior anti-HIV efficacy of the cationic EFV-NLCs compared to EFV-loaded NLCs.
PHARMACEUTICAL SCIENCES
(2021)