Article
Medicine, General & Internal
Prateek Sharma, Gary W. W. Falk, Menaka Bhor, A. Burak Ozbay, Dominick Latremouille-Viau, Annie Guerin, Sherry Shi, Margaret M. M. Elvekrog, Paul Limburg
Summary: This study addresses the prevalence of GERD, BE, and BERN in the US, as well as the utilization patterns of upper endoscopy. The results show an increase in upper endoscopy utilization from GERD to BE to BERN, and a decrease in time between upper endoscopies as the disease stage progresses from BE to BERN.
Article
Primary Health Care
Carl Bryce, Merima Bucaj, Renee Gazda
Summary: Barrett's esophagus is a premalignant change of the esophagus, but malignant transformation to esophageal adenocarcinoma is rare without dysplasia. Risk factors for Barrett's esophagus include gastroesophageal reflux disease, obesity, age older than 50 years, male sex, tobacco use, and a family history of Barrett's esophagus or esophageal adenocarcinoma. Screening should be considered for patients with chronic gastroesophageal reflux symptoms and additional risk factors. Diagnosis of Barrett's esophagus is confirmed through visualizing mucosal changes during upper endoscopy and biopsy. Management depends on the presence and severity of dysplasia, with endoscopic treatment reducing the risk of malignant transformation.
AMERICAN FAMILY PHYSICIAN
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sung-Goo Kang, Hyun Jee Hwang, Youngwoo Kim, Junseak Lee, Jung Hwan Oh, Jinsu Kim, Chul-Hyun Lim, Seung Bae Youn, Sung Hoon Jung
Summary: The study evaluated the association between reflux esophagitis and fatigue, finding no statistically significant association between reflux esophagitis and daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, being women, anxiety, and depression. Further research is needed to clarify the relationship between fatigue and reflux esophagitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
L. Lallemand, E. Duchalais, N. Musquer, D. Jacobi, E. Coron, S. Bruley des Varannes, E. Mirallie, C. Blanchard
Summary: The study highlights the incidence of postoperative GERD and endoscopic lesions following sleeve gastrectomy. While SG is not contraindicated in cases of reflux, patients may require close endoscopic surveillance post-surgery. Some patients also reported a lack of regular medical follow-up after 5 years.
Review
Medicine, General & Internal
Prateek Sharma
Summary: Barrett esophagus affects approximately 5% of people in the US and approximately 1% worldwide, with a risk of developing esophageal adenocarcinoma. Management typically includes acid-suppressive medications and periodic surveillance endoscopy.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Xuening Zhang, Xiaorong Yang, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ming Lu
Summary: Educational attainment is related to the risk of esophageal cancer, Barrett's esophagus, and gastroesophageal reflux disease. Genetically predicted higher educational attainment has a protective effect on these diseases, partly mediated by reducing adiposity, smoking, and depression.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Xiaoyu Wang, Puya Gharahkhani, David M. Levine, Rebecca C. Fitzgerald, Ines Gockel, Douglas A. Corley, Harvey A. Risch, Leslie Bernstein, Wong-Ho Chow, Lynn Onstad, Nicholas J. Shaheen, Jesper Lagergren, Laura J. Hardie, Anna H. Wu, Paul D. P. Pharoah, Geoffrey Liu, Lesley A. Anderson, Prasad G. Iyer, Marilie D. Gammon, Carlos Caldas, Weimin Ye, Hugh Barr, Paul Moayyedi, Rebecca Harrison, R. G. Peter Watson, Stephen Attwood, Laura Chegwidden, Sharon B. Love, David MacDonald, John DeCaestecker, Hans Prenen, Katja Ott, Susanne Moebus, Marino Venerito, Hauke Lang, Rupert Mayershofer, Michael Knapp, Lothar Veits, Christian Gerges, Josef Weismueller, Matthias Reeh, Markus M. Noethen, Jakob R. Izbicki, Hendrik Manner, Horst Neuhaus, Thomas Roesch, Anne C. Boehmer, Arnulf H. Hoelscher, Mario Anders, Oliver Pech, Brigitte Schumacher, Claudia Schmidt, Thomas Schmidt, Tania Noder, Dietmar Lorenz, Michael Vieth, Andrea May, Timo Hess, Nicole Kreuser, Jessica Becker, Christian Ell, Ian Tomlinson, Claire Palles, Janusz A. Jankowski, David C. Whiteman, Stuart MacGregor, Johannes Schumacher, Thomas L. Vaughan, Matthew F. Buas, James Y. Dai
Summary: This study identified novel genetic susceptibility loci for esophageal adenocarcinoma and Barrett esophagus using an eQTL set-based genetic association approach, expanding the pool of genetic susceptibility loci.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Gastroenterology & Hepatology
Melissa Schmidt, Richard J. Hackett, Ann-Marie Baker, Stuart A. C. McDonald, Michael Quante, Trevor A. Graham
Summary: Cancer development is a dynamic evolutionary process with intratumoural heterogeneity. Barrett's esophagus serves as a model system to study malignant evolution, with evidence suggesting pre-programmed progression to esophageal adenocarcinoma years before clinical detection. Understanding the evolutionary dynamics of Barrett's esophagus may lead to novel therapeutic targets and personalized surveillance programs to prevent progression to EAC.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
Zhiqiang Liu, Xiaoli Gao, Lirong Liang, Xuan Zhou, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Shu Deng, Zuomin Wang, Chen Wang
Summary: The purpose of this study was to assess the prevalence and identify the risk factors of gastroesophageal reflux disease (GERD) in the Chinese adult population. Data from a nationally representative sample of Chinese adults were collected, and the overall prevalence of GERD was found to be 5.6%. Women, smokers, older individuals, those with higher BMI, urban residents, individuals with lower education level or comorbidities were more likely to have GERD. Symptoms of severe periodontitis and lower frequency of tooth brushing were significantly associated with the risk of GERD.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yan-Lin Du, Ru-Qiao Duan, Li-Ping Duan
Summary: The study found a significant inverse relationship between Hp, especially the CagA-positive Hp strain, and BE, but no significant difference in Hp infection prevalence was observed between BE patients and the GERD control group. Hp was negatively correlated with long-segment BE and associated with a reduced risk of dysplasia, but had no correlation with short-segment BE.
BMC GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Gary E. Markey, Claire L. Donohoe, Eoin N. McNamee, Joanne C. Masterson
Summary: MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate mRNA targets through RNA interference. They play a crucial role in physiological and pathological processes including cell proliferation, differentiation, apoptosis, and inflammation. This review discusses the potential of miRNAs in overall esophageal disease, focusing on eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC). The dysregulation of miRNA expression in these diseases highlights their key role in disease progression and suggests their potential as diagnostic and prognostic biomarkers. Furthermore, targeting miRNAs could be a therapeutic option for esophageal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Surgery
Marialuisa Lugaresi, Benedetta Mattioli, Niccolo Daddi, Francesco Bassi, Vladimiro Pilotti, Luca Ferruzzi, Sandro Mattioli
Summary: The study found that 31.8% of patients undergoing GERD/HH surgery had true short esophagus (TSE), and satisfactory results can be achieved using CN and SASF surgeries performed according to determined surgical principles. This finding necessitates confirmation through a prospective multicenter study.
Article
Public, Environmental & Occupational Health
Shuai Yuan, Susanna C. Larsson
Summary: Observational studies have shown associations between adiposity, diabetes, and lifestyle factors with gastroesophageal reflux disease (GERD). This study used Mendelian randomization analysis and found causal roles of adiposity, diabetes, and smoking, and a possible role of high caffeine consumption in the development of GERD.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
