Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models

A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors

(2021) Barbara Costa et al.   Cancers

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

(2021) Natalia Ochocka et al.   Nature Communications

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

(2021) Ester Gangoso et al.   CELL

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages

(2020) Ilaria Marigo et al.   Cancer Discovery

Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma

(2020) Anne Blank et al.   JOURNAL OF PATHOLOGY

Engineering cytokines and cytokine circuits

(2020) Aileen W. Li et al.   SCIENCE

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

Molecular responses to immune checkpoint blockade in glioblastoma

(2019) Hirotaka Ito et al.   NATURE MEDICINE

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Metabolic Control of Dendritic Cell Functions: Digesting Information

(2019) Stefanie K. Wculek et al.   Frontiers in Immunology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

(2019) Sangeeta Goswami et al.   NATURE MEDICINE

T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

(2018) Karolina Woroniecka et al.   CLINICAL CANCER RESEARCH

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

(2018) Giulia Escobar et al.   Nature Communications

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

IFN  gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment

(2016) M. Catarinella et al.   EMBO Molecular Medicine

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

(2016) Christine E. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

Interleukin 12: still a promising candidate for tumor immunotherapy?

(2014) Witold Lasek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Genetic Engineering of Hematopoiesis for Targeted IFN-  Delivery Inhibits Breast Cancer Progression

(2014) G. Escobar et al.   Science Translational Medicine

Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

(2013) J.-Y. Shi et al.   CLINICAL CANCER RESEARCH

Functional Neuroprotection and Efficient Regulation of GDNF Using Destabilizing Domains in a Rodent Model of Parkinson’s Disease

(2013) Luis Quintino et al.   MOLECULAR THERAPY

Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells

(2012) Virna Marin et al.   Human Gene Therapy Methods

Identification of Hematopoietic Stem Cell-Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy

(2010) B. Gentner et al.   Science Translational Medicine

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

(2008) Michele De Palma et al.   CANCER CELL

Chemical control of protein stability and function in living mice

(2008) Laura A Banaszynski et al.   NATURE MEDICINE