Article
Endocrinology & Metabolism
Jonatan Bagger, Magnus F. G. Grondahl, Asger Lund, Jens J. Holst, Tina Vilsboll, Filip K. Knop
Summary: The study showed that GLP-1 potentiated the glucagon-suppressive effect of glucose in a dose-dependent manner in healthy individuals and patients with type 2 diabetes. However, patients with type 1 diabetes were insensitive to the glucagonostatic effects of both glucose and GLP-1.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Nutrition & Dietetics
Wei-Lun Wen, Hui-Chun Huang, Hsiu-Chu Lin, Wan-Ching Lo, Szu-Chia Chen, Mei-Yueh Lee
Summary: In patients newly diagnosed with T2DM, glycemic durability is negatively associated with higher glycemic burden.
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Review
Nutrition & Dietetics
Alessia Quarta, Miriana Guarino, Roberta Tripodi, Cosimo Giannini, Francesco Chiarelli, Annalisa Blasetti
Summary: In children with type 1 diabetes, a healthy lifestyle is crucial for glycemic control and reducing inflammatory effects. Glycemic index and load are important indicators to assess the quality of food consumed. Recent studies have shown that incorporating low-glycemic-index foods into the diet can result in better glycemic stability and reduced hyperglycemic peaks.
Article
Biochemistry & Molecular Biology
Ahmad Haidar, Leif Erik Lovblom, Nancy Cardinez, Nikita Gouchie-Provencher, Andrej Orszag, Michael A. Tsoukas, C. Marcelo Falappa, Adnan Jafar, Milad Ghanbari, Devrim Eldelekli, Joanna Rutkowski, Jean-Francois Yale, Bruce A. Perkins
Summary: New research shows that empagliflozin improves time in range for patients with type 1 diabetes using a closed-loop automated insulin delivery system. Adding empagliflozin to the closed-loop system improves glycemic control and increases time spent in the target glucose range.
Article
Microbiology
Chih-Wei Luan, Chia-Yen Liu, Yao-Hsu Yang, Ming-Shao Tsai, Yao-Te Tsai, Cheng-Ming Hsu, Ching-Yuan Wu, Pey-Jium Chang, Geng-He Chang
Summary: Deep neck infection is a deadly condition, especially for patients with diabetes. Treatment involves surgical drainage and antibiotics, with Klebsiella pneumoniae and Viridans Streptococci being common pathogens. Patients with diabetes have higher mortality risks when infection markers are elevated.
Article
Medicine, General & Internal
Jennifer M. Ladd, Atul Sharma, Elham Rahme, Kristine Kroeker, Marjolaine Dube, Marc Simard, Celine Plante, Claudia Blais, Marni Brownell, Celia Rodd, Meranda Nakhla
Summary: This study compares socioeconomic status (SES) disparities in insulin pump uptake in children with type 1 diabetes (T1D) in Quebec (fully funded pumps) and Manitoba (partially funded pumps). Results suggest that full coverage programs in Quebec partially mitigate SES disparities in uptake and may serve as a model to improve access for all children with T1D.
Article
Medicine, General & Internal
Shweta Urva, Tamer Coskun, Mei Teng Loh, Yu Du, Melissa K. Thomas, Sirel Gurbuz, Axel Haupt, Charles T. Benson, Martha Hernandez-Illas, David A. D'Alessio, Zvonko Milicevic
Summary: LY3437943, a multi-receptor agonist for the treatment of type 2 diabetes and obesity, demonstrated acceptable safety, suitable pharmacokinetics for once-weekly dosing, and significant improvements in glucose and bodyweight outcomes in this study.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Medicine, General & Internal
Julio Rosenstock, Juan Frias, Ania M. Jastreboff, Yu Du, Jitong Lou, Sirel Gurbuz, Melissa K. Thomas, Mark L. Hartman, Axel Haupt, Zvonko Milicevic, Tamer Coskun
Summary: In this randomized trial, retatrutide showed clinically meaningful improvements in glycemic control and robust reductions in bodyweight in people with type 2 diabetes, with a safety profile consistent with GLP-1 receptor agonists and GIP and GLP-1 receptor agonists.
Article
Clinical Neurology
Jay A. Brieler, Joanne Salas, Elizabeth Keegan-Garrett, Jeffrey F. Scherrer
Summary: This study investigated the association between acute phase antidepressant medication treatment and glycemic control in patients with type 2 diabetes. The results showed that acute phase treatment was significantly associated with achieving glycemic control within 36 months, but not beyond 36 months. There was no association between acute vs. less than acute phase treatment and glycemic control.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Karin Adamo, Ulf Gunnarsson, Katarina Eeg-Olofsson, Karin Strigard, Fredrik Brannstrom
Summary: The study found that patients with type 1 diabetes had a lower rate of perianal abscess than those with type 2 diabetes, but poor glycemic control increased the risk for perianal abscess. Complications related to poor glycemic control were also associated with a higher incidence of perianal abscess.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Diana Sagastume, Elly Mertens, Deogratias Katsuva Sibongwere, Jean-Claude Dimbelolo, Jean Clovis Kalobu Kabundi, Jeroen de Man, Josefien Van Olmen, Jose L. Penalvo
Summary: This study analysed the clinical data of patients with type 2 diabetes in Kinshasa, the Democratic Republic of the Congo, and found that overall glycemic control was poor but showed some improvement over time. Older patients had a higher chance of achieving glycemic control, while younger patients should be prioritized for attention.
Article
Endocrinology & Metabolism
Jarvis C. Noronha, Jeffrey I. Mechanick
Summary: This article discusses the role of diabetes-specific nutrition formulas (DSNFs) as meal replacements in the prevention and management of type 2 diabetes. DSNFs are shown to improve glycemic control and cardiometabolic outcomes in both short- and long-term studies. The transcultural diabetes nutrition algorithm can be utilized to facilitate the delivery of DSNFs in clinical settings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Medicine, General & Internal
Carlos Alatorre, Eric H. Schultz, David R. Nelson
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2016)
Article
Economics
Emily Nash Smyth, Ilaria Conti, James E. Wooldridge, Lee Bowman, Li Li, David R. Nelson, Daniel E. Ball
JOURNAL OF MEDICAL ECONOMICS
(2016)
Article
Emergency Medicine
Michael A. Kaufmann, David R. Nelson, Puneet Kaushik, N. Clay Mann, Beth Mitchell
PREHOSPITAL EMERGENCY CARE
(2019)
Meeting Abstract
Economics
C. Radawski, D. R. Nelson, A. Nyhuis, B. Mitchell, J. A. Johnston
Article
Economics
Janet H. Ford, Wenyu Ye, Russell M. Nichols, Shonda A. Foster, David R. Nelson
JOURNAL OF MEDICAL ECONOMICS
(2019)
Article
Multidisciplinary Sciences
Joseph A. Johnston, David R. Nelson, Limin Zhang, Sarah E. Curtis, James R. Voelker, John R. Wetterau
Article
Public, Environmental & Occupational Health
Julie Beyrer, David R. Nelson, Kristin M. Sheffield, Yu-Jing Huang, Tim Ellington, Ana L. Hincapie
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Multidisciplinary Sciences
Joseph A. Johnston, David R. Nelson, Pallav Bhatnagar, Sarah E. Curtis, Yu Chen, James G. MacKrell
Summary: Essential fructosuria (EF) is a rare, benign, autosomal recessive condition caused by loss-of-function variants in the ketohexokinase gene, leading to the intermittent appearance of fructose in the urine. Limited knowledge exists regarding the long-term clinical consequences of ketohexokinase gene variants, mainly due to the ongoing preliminary research in this field.
Article
Multidisciplinary Sciences
David R. Nelson, Jacqueline Brown, Aki Morikawa, Michael Method
Summary: This study aimed to investigate the impact of breast cancer subtypes on breast cancer-specific mortality in early breast cancer (EBC) and the incidence of high-risk indicators for recurrence. It also examined the mortality risk difference between patients who met/did not meet the high-risk criteria defined in the monarchE trial.
Article
Medicine, General & Internal
Iris Goetz, Casey Choong, Jennifer Winnie, David R. Nelson, Julie Birt, Virginia Noxon, Helen Varker, Nicole Zimmerman, Joseph Tkacz
Summary: This study developed a claims-based algorithm to identify flares of systemic lupus erythematosus (SLE) using a linked claims-electronic medical record (EMR) dataset. The algorithm showed promise in providing an alternative and streamlined way to identify flares in administrative claims data, which will advance the study of SLE within the context of flares.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Criminology & Penology
Janet H. Ford, Terrell W. Zollinger, Jianjun Zhang, Joseph O'Neil, David R. Nelson, Gregory K. Steele
Summary: This study analyzed the association between physical fighting behavior among adolescents and depressed mood/suicidal behaviors among female youths from 2001 to 2015. The odds of depressed mood/suicidal behaviors have been increasing, with electronic bullying contributing to polyvictimization.
JOURNAL OF INTERPERSONAL VIOLENCE
(2021)
Article
Medicine, General & Internal
Carlos I. Alatorre, Byron J. Hoogwerf, Mark A. Deeg, David R. Nelson, Theresa M. Hunter, Wee Teck Ng, Mark D. Rekhter
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Meeting Abstract
Endocrinology & Metabolism
Beth D. Mitchell, David R. Nelson, Michael Kaufmann
Meeting Abstract
Endocrinology & Metabolism
Magaly Perez-Nieves, Daniel Girdano, David R. Nelson