Article
Physiology
Lianguo Wang, Rachel C. Myles, I-Ju Lee, Donald M. Bers, Crystal M. Ripplinger
Summary: The study demonstrates that inhibition of SERCA can slow down SR Ca2+ reuptake, leading to an increase in the magnitude of Ca2+ alternans in cardiac cells, especially at fast pacing frequencies. Notably, the alternation of SR Ca2+ release precedes the alternation of SR Ca2+ load during rapid ventricular pacing.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuan Xiong, Xiaoqin Zhang, Yuan Zhang, Jiaqi Xie, Yuan Bian, Qinan Yin, Rongsheng Tong, Dongke Yu, Lingai Pan
Summary: This study found that TCEP exposure can cause cardiac fibrosis by inhibiting the expression of SERCA and leading to Ca2+ overload, which in turn triggers ER stress and overactive autophagy. The results reveal the important role of the Ca2+ overload/ER stress/autophagy axis in TCEP-induced cardiotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Weixing Zhu, Yanwei Duan, Jiqiang Chen, Hans Merzendorfer, Xu Zou, Qing Yang
Summary: The study identified a novel role of DmSERCA in chitin synthesis, demonstrating its physical interaction with epidermal chitin synthase and its importance in chitin deposition and structure formation in Drosophila melanogaster.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ha Thu Nguyen, Carlos Noriega Polo, Andreas Wiederkehr, Claes B. Wollheim, Kyu-Sang Park
Summary: Enhancing endoplasmic reticulum (ER) calcium uptake through activation of the sarco/endoplasmic reticulum calcium ATPase (SERCA) can improve survival and function of pancreatic ss-cells. Activation of SERCA increases insulin synthesis and exocytosis, enhances sensitivity to glucose, and improves mitochondrial bioenergetics and antioxidant capability. Targeting SERCA could be a promising therapeutic strategy for protecting ss-cells from lipotoxicity and Type 2 diabetes development.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Toyokazu Kimura, Kazuki Kagami, Atsushi Sato, Ayumu Osaki, Kei Ito, Shunpei Horii, Takumi Toya, Nobuyuki Masaki, Risako Yasuda, Yuji Nagatomo, Takeshi Adachi
Summary: This study found that SERCA2 protein expression decreased in the aorta of diabetic mice, and CDN1163 improved aortic endothelial dysfunction, glucose tolerance, hepatosteatosis, and skeletal muscle function in these mice.
Article
Anatomy & Morphology
Wanying Chen, Mengmeng Li, Xiangyu Lei, Yawen Cheng, Xiaoyu Wu, Xinyue Sun, Yixuan Wu, Zhiheng Li, Guogang Luo, Meng Wei
Summary: Our study found that remote ischemic postconditioning (RIPostC) can alleviate brain ischemic injury by reducing endoplasmic reticulum (ER) stress, providing a theoretical basis for the protective mechanism of ischemic stroke.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Oncology
Zhidong Li, Jia Guo, Yunfei Bian, Mingsheng Zhang
Summary: The study found that IMD can protect cardiomyocytes against thapsigargin-induced apoptosis, at least partially by activating the protein kinase A/SERCA pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Soraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and beta-cell dysfunction, and its incidence is increasing worldwide. Research has shown that long-term high blood sugar leads to beta-cell failure and death through endoplasmic reticulum (ER) stress. Herbal compounds such as ginsenoside compound K, baicalein, quercetin, and resveratrol have demonstrated significant improvement of T2DM through modulation of ER stress. These findings suggest that herbal constituents have the potential to prevent and treat various complications of T2DM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Shahnawaz D. Jadeja, Jay M. Mayatra, Jayvadan Vaishnav, Nirali Shukla, Rasheedunnisa Begum
Summary: Vitiligo is a skin disorder characterized by depigmented macules on the skin, resulting from autoimmune destruction of melanocytes. Oxidative stress and autoimmunity play crucial roles in the onset and progression of the disease, and endoplasmic reticulum stress may serve as a connecting link between them.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Marta Sobolczyk, Joanna Mackiewicz, Malwina Lisek, Bozena Ferenc, Feng Guo, Ludmila Zylinska
Summary: Calcium plays crucial roles in mammalian neurons, with its concentration tightly regulated by calcium pumps to prevent detrimental consequences. These pumps not only transport calcium ions but also have tissue-specific functionalities and are regulated by calmodulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Jing Zheng, Shane Antrobus, Wei Feng, Trevor N. Purdy, Bradley S. Moore, Isaac N. Pessah
Summary: This study found that bromopyrroles can influence neuronal network activity, with higher concentrations of TBP leading to a slow and sustained elevation in cytoplasmic calcium levels, ultimately resulting in loss of neuronal viability. The potential ecological and health impacts of bromopyrroles warrant further investigation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin
Summary: This study elucidates the role and mechanism of SERCA2b gene mutants in glutamate-induced excitotoxicity, showing that they worsen cell damage by accelerating Ca2+ depletion and causing ER stress and mitochondrial Ca2+ overload. Enhancing SERCA2b pumping capacity or inhibiting Ca2+ leakage can alleviate this toxicity response.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Ruqing Qiu, Ziyi Wang, Xiaojing Wei, Hui Sui, Zongzhi Jiang, Xue-fan Yu
Summary: Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy with three subtypes based on serum antibodies. The pathogenesis of IMNM is primarily immune-mediated, but recent studies have highlighted the involvement of non-immune mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Juncheng Wei, Deyu Fang
Summary: Hepatocellular carcinoma is a major cause of cancer mortality globally, and its pathogenesis involves the interplay of ER stress and unfolded protein response. The liver's susceptibility to ER stress, due to its functions in protein synthesis and detoxification, may play a crucial role in HCC development and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Iyuki Namekata, Ryosuke Odaka, Shunsuke Hamazaki, Hina Nisaka, Shogo Hamaguchi, Hikaru Tanaka
Summary: A method using fluorescence microscopy and specific inhibitors was developed to evaluate the activity of NCX and SERCA in mouse ventricular cardiomyocytes. Different adrenoceptor stimulations and inhibitors exhibited distinct effects on cytoplasmic Ca2+ concentration in non-beating ventricular cardiomyocytes, suggesting potential applications for pharmacological evaluations targeting NCX and SERCA.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Editorial Material
Dermatology
M. Kamijo
BRITISH JOURNAL OF DERMATOLOGY
(2016)
Letter
Dermatology
Maya Kamijo, Akino Wada, Reiko Mineki, Tamami Sakanishi, Shigaku Ikeda
JOURNAL OF DERMATOLOGICAL SCIENCE
(2016)
Article
Dermatology
M. Kamijo, C. Nishiyama, A. Takagi, N. Nakano, M. Hara, S. Ikeda, K. Okumura, H. Ogawa
BRITISH JOURNAL OF DERMATOLOGY
(2012)
Editorial Material
Dermatology
M. Kaga-Kamijo, S. Ikeda
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Daniel P. Potaczek, Maya Kamijo, Mutsuko Hara, Ko Okumura, Anetta Undas, Chiharu Nishiyama
MOLECULAR BIOLOGY REPORTS
(2012)
Article
Dermatology
M. Kaga, T. Sugita, A. Nishikawa, Y. Wada, M. Hiruma, S. Ikeda
Letter
Dermatology
Maho Yasui, Mariko Hattori, Nozomi Ikegami, Maya Kaga, Yumi Ogawa, Masataro Hiruma
Letter
Dermatology
Maya Kaga-Kamijo, Shigaku Ikeda
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Yuri Ikeda, Maya Kaga, Hiroshi Koide, Shigaku Ikeda
JOURNAL OF DERMATOLOGY
(2021)
