Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study

A putative antipruritic mechanism of the phosphodiesterase-4 inhibitor E6005 by attenuating capsaicin-induced depolarization of C-fibre nerves

(2015) Hisashi Wakita et al.   EXPERIMENTAL DERMATOLOGY

Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis

(2015) Fuminori Ohba et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Is Adult Atopic Eczema More Common Than We Think? – A Population-based Study in Danish Adults

(2014) G Vinding et al.   ACTA DERMATO-VENEREOLOGICA

Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch-related responses in mice with chronic atopy-like dermatitis

(2014) Tsugunobu Andoh et al.   EXPERIMENTAL DERMATOLOGY

Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: Inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP

(2014) Tsugunobu Andoh et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: Results of a randomized, vehicle-controlled, multicenter clinical trial

(2014) Masutaka Furue et al.   JOURNAL OF DERMATOLOGY

Systemic therapy for atopic dermatitis

(2013) D. Simon et al.   ALLERGY

Characterization of different courses of atopic dermatitis in adolescent and adult patients

(2013) D. Garmhausen et al.   ALLERGY

Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012)

(2013) Amadeu Gavaldà et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

EASI, (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference

(2011) M. E. Schram et al.   ALLERGY

Regulation of the immune response and inflammation by histamine and histamine receptors

(2011) Liam O’Mahony et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PDE4 inhibitors: a review of current developments (2005 – 2009)

(2009) Lluís Pagès et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Guidelines for management of atopic dermatitis

(2009) Hidehisa SAEKI et al.   JOURNAL OF DERMATOLOGY

ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis

(2009) U Darsow et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Is eczema really on the increase worldwide?

(2007) Hywel Williams et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY