Article
Oncology
Yu Zhang, Peigang Ji, Shoujie Wang, Huaizhou Qin, Qing Cai
Summary: This study aimed to evaluate the rate, reasons, and predictors of unplanned reoperation after craniotomy for glioma in a consecutive series at a single institution. The study found that glioma properties and blood pressure management were decisive predictors of early unplanned reoperation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Francisco Martin-Rodriguez, Ancor Sanz-Garcia, Enrique Castro-Portillo, Juan F. Delgado-Benito, Carlos del Pozo Vegas, Guillermo Ortega Rabbione, Francisco Martin-Herrero, Jose Luis Martin-Conty, Raul Lopez-Izquierdo
Summary: Elevated troponin T values are associated with comorbidities and early mortality. This study evaluated the prognostic accuracy of prehospital point-of-care cardiac troponin T to identify the risk of early in-hospital deterioration, including mortality within 28 days. The study found that cTnT had a high predictive ability for mortality and could stratify risk into high, intermediate, and low categories.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Critical Care Medicine
Jing Yang, Shaohua Liu, Jingli Lu, Tongwen Sun, Peile Wang, Xiaojian Zhang
Summary: This study aimed to establish an AUC(ss,24 h) threshold for polymyxin B, finding that an AUC(ss,24 h) threshold of 50-100 mg h/L was associated with decreased nephrotoxicity while assuring clinical efficacy for critically ill patients.
Article
Oncology
Jingru Yu, Alexander Ploner, Maximilian Kordes, Matthias Lohr, Magnus Nilsson, Maria Evangelina Lopez de Maturana, Lidia Estudillo, Harald Renz, Alfredo Carrato, Xavier Molero, Francisco X. Real, Nuria Malats, Weimin Ye
Summary: This study identified and externally validated a panel of eight protein biomarkers that can potentially allow early detection of pancreatic ductal adenocarcinoma (PDAC). The proteins were able to distinguish between early PDAC and healthy individuals, as well as between advanced PDAC and healthy controls, in two populations.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Immunology
Chrysovalantis Stafylis, Kori Keith, Shivani Mehta, David Tellalian, Pamela Burian, Carl Millner, Jeffrey D. Klausner
Summary: This study evaluated the efficacy of oral cefixime 400 mg in the treatment of syphilis, with a successful treatment rate of 87%.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Psychology, Clinical
Alex M. Mirman, Juliana Corlier, Andrew C. Wilson, Reza Tadayonnejad, Katharine G. Marder, Christopher M. Pleman, David E. Krantz, Scott A. Wilke, Jennifer G. Levitt, Nathaniel D. Ginder, Rashi Ojha, Zafiris J. Daskalakis, Andrew F. Leuchter, Jonathan C. Lee
Summary: This study evaluated early changes in sleep, anxiety, and mood as predictors of nonresponse to repetitive transcranial magnetic stimulation (rTMS) treatment. The lack of early mood improvement was identified as a practical method to predict nonresponse, indicating a need for treatment protocol change in patients with severe baseline depression and minimal early mood improvement.
DEPRESSION AND ANXIETY
(2022)
Article
Oncology
Xujun Zhang, Kefan Bi, Xiaoxuan Tu, Qiong Zhang, Qingyi Cao, Yan Liang, Ping Zeng, Lin Wang, Tianxing Liu, Weijia Fang, Hongyan Diao
Summary: Effective cetuximab treatment induces an increase in IL-33 level and decrease in OPN level in the peripheral blood at 4 weeks after treatment, as well as an increase in NK and CD8(+) T cells. Higher expression of CD137 and CD107a on NK cells is also observed in the effective group compared to the ineffective group. Additionally, in vitro cetuximab treatment increases NK and CD8(+) T cells, as well as CD137 and CD107a expression upon IL-33 stimulation.
Article
Clinical Neurology
Wei Zheng, Mei He, Li-Mei Gu, Guo-Hui Lao, Dan-Feng Wang, Jian-Xin Mai, Hua-Wang Wu, Sha Nie, Xiong Huang
Summary: Early symptom improvement can predict eventual remission in TRD patients undergoing ECT with ketofol anesthesia. A 45% reduction in HAMD-17 score after 3 ECT sessions was found to be the optimal definition of early improvement for predicting final remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Ryota Sagami, Takao Sato, Kazuhiro Mizukami, Mitsuteru Motomura, Kazuhisa Okamoto, Satoshi Fukuchi, Yuichiro Otsuka, Takashi Abe, Hideki Ono, Kei Mori, Kurato Wada, Tomoyuki Iwaki, Hidefumi Nishikiori, Koichi Honda, Yuji Amano, Kazunari Murakami
Summary: This study aimed to clarify the factors associated with early stage pancreatic ductal adenocarcinoma (PDAC). Through a retrospective analysis, clinical indicators, risk factors, and imaging findings were identified as significant factors for early stage PDAC detection. A new screening strategy based on these factors showed a relatively high sensitivity, specificity, and areas under the curve, suggesting its potential for early stage PDAC detection.
Article
Oncology
Mingming Deng, Run Tong, Zhe Zhang, Tao Wang, Chaonan Liang, Xiaoming Zhou, Gang Hou
Summary: In this study, we found that increased EFNA3 expression in LUAD patients predicted worse clinical prognosis, promoted LUAD cell proliferation and glycolysis ability, and was related to immunotherapy response. Mechanistically, EFNA3 may be involved in pathways related to nuclear division, synaptic function, and ion channel activity. Furthermore, EFNA3 was negatively correlated with immunity, stromal infiltration, and various tumor infiltrating immune cells (TIICs), but positively associated with multiple immunotherapy biomarkers.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Peile Wang, Hongchang Xie, Qiwen Zhang, Xueke Tian, Yi Feng, Zifei Qin, Jing Yang, Wenjun Shang, Guiwen Feng, Xiaojian Zhang
Summary: This study compares the pharmacokinetic properties of mycophenolic acid (MPA) in adult renal transplant patients at different stages and simulates optimal dosing regimens. The results show significant differences in pharmacokinetic parameters between early and stable stage patients, with significantly lower AUC in the early stage. Monte Carlo simulations suggest that dosing 1.0-1.5 g of mycophenolate mofetil twice daily in the early phase and 0.50-0.75 g twice daily in the stable phase can achieve the desired drug exposure levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wasan Katip, Peninnah Oberdorfer
Summary: This study found that a vancomycin AUC/MIC of >=400 mg·h/L was associated with significant differences in clinical and microbiological responses, but also increased the risk of nephrotoxicity. Adjusting vancomycin dosage to achieve the optimal AUC/MIC target ≥400 mg·h/L is crucial for the treatment of enterococcal infections.
Article
Clinical Neurology
Hongyan Chen, Yang He, Xiaoling Zeng, Qing Chen, Niya Zhou, Huan Yang, Wenzheng Zhou, Liwen Zhang, Rong Yang, Qiao Huang, Hua Zhang
Summary: The subjective sleep quality during the first trimester may be associated with elevated blood glucose levels and an increased risk of gestational diabetes mellitus (GDM) later in pregnancy.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Biochemistry & Molecular Biology
Keiichi Haga, Tomoyoshi Shibuya, Taro Osada, Shunsuke Sato, Yuka Fukuo, Osamu Kobayashi, Toshio Yamada, Daisuke Asaoka, Kentaro Ito, Kei Nomura, Mayuko Haraikawa, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Mariko Hojo, Akihito Nagahara
Summary: This study found that VDZ is effective in the majority of UC patients, with a high rate of mucosal healing even in those who have previously failed biological therapy. Early clinical remission can predict long-term remission, and week 6 can be a useful evaluation point when using VDZ for UC treatment.
Article
Pharmacology & Pharmacy
Zoltan Somogyi, Patrik Mag, Dora Kovacs, Adam Kerek, Pal Szabo, Laszlo Makrai, Akos Jerzsele
Summary: This study presents the pharmacokinetic behavior of florfenicol in swine synovial fluid for the first time and recommends extrapolated critical minimum inhibitory concentrations of S. suis for successful treatment of S. suis arthritis in swine. It highlights the need for a different dosage regimen compared to authorized florfenicol formulations.
Article
Dermatology
Ali Al-Janabi, Amy Charlotte Foulkes, Christopher Ernest Maitland Griffiths, Richard Bruce Warren
Summary: This retrospective case series identified cases of paradoxical eczema developing in biologic-treated patients with psoriasis, with some cases showing eosinophilia and elevated serum IgE levels. Treatment strategies included discontinuation or switch of biologic therapy, as well as topical corticosteroids and broad-acting systemic agents. However, some patients still experienced persistent eczema and psoriasis despite discontinuing all biologic therapies.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Dermatology
Suzanne M. Pilkington, Silvia Bulfone-Paus, Christopher E. M. Griffiths, Rachel E. B. Watson
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Dermatology
Claire Reid, Charlotte Welsh, Holly Martin-Smith, Soney Dharmaprasad, Richard B. Warren, Lis Cordingley, Christopher E. M. Griffiths
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
K. T. Mellody, A. C. Kendall, J. R. Wray, A. R. Foster, A. K. Langton, P. Costello, V. L. Newton, M. Bell, C. E. M. Griffiths, A. Nicolaou, R. E. B. Watson, S. M. Pilkington
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Siew Eng Choon, Alison K. Wright, Christopher E. M. Griffiths, Kwee Eng Tey, Kit Wan Wong, Yoong Wei Lee, Ushananthiny Suvelayutnan, Jeevitha Mariapun, Darren M. Ashcroft
Summary: This study conducted an 11-year investigation in Malaysia and found an increasing incidence and prevalence of psoriasis. The rates varied by age, sex, and ethnicity.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Athanasios Niaouris, Ariana Hernandez-Cordero, Salma Haddad, Niina Karoliina Hassi, Natashia Benzian-Olsson, Carmen Bugarin Diz, A. David Burden, Hywel L. Cooper, Christopher E. M. Griffiths, Richard Parslew, Andrew E. Pink, Nick J. Reynolds, Shyamal Wahie, Richard B. Warren, Andrew Wright, Michael Simpson, Patrick Baum, Sudha Visvanathan, Jonathan N. Barker, Catherine H. Smith, Francesca Capon
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Dermatology
Valeska Padovese, Lucinda C. Fuller, Christopher E. M. Griffiths, Toby Maurer, Esther Freeman
Summary: Skin diseases are prevalent in refugee camps due to a lack of skilled professionals, limited access to diagnostics and medications. This perspective highlights the importance of dermatologists in providing adequate care for migrants and displaced persons during humanitarian crises.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yiqiao Chen, Christopher E. M. Griffiths, Silvia Bulfone-Paus
Summary: The skin is equipped with immune cells like mast cells and CD8 T cells which play a role in recognizing and responding to environmental challenges. These cells are essential for maintaining tissue balance and regulating the immune response in skin diseases. Studies have shown that mast cells can influence the migration and function of CD8 T cells, while CD8 T cells can also activate mast cells. The close proximity between mast cells and CD8 T cells has been observed in dermatoses such as alopecia areata. This review summarizes the bidirectional interactions between human mast cells and CD8 T cells, focusing on their involvement in psoriasis, atopic dermatitis, and vitiligo, and discusses unresolved questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dermatology
Jorg C. Prinz, Siew Eng Choon, Christopher E. M. Griffiths, Joseph F. Merola, Akimichi Morita, Darren M. Ashcroft, Manuelle Viguier
Summary: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease with acute episodes of pustule formation. Understanding the epidemiology and clinical data of GPP is challenging due to its rarity. This review article provides an overview of GPP prevalence estimates in key demographics, genetic mutations associated with the disease, incidence of comorbidities, mortality rate, and causes of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Duc Binh Phan, Anthony P. Bewley, Catherine H. Smith, Teena Mackenzie, Christopher E. M. Griffiths, Mark Lunt, Richard B. Warren, Zenas Z. N. Yiu
Summary: This study investigated the uptake of TNFi biosimilars in the UK and Ireland and found that the use of biosimilars increased over time and varied across regions. Biosimilars were more commonly used by men and patients with lower disease severity.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Leena Chularojanamontri, Krittaya Rattanakorn, Narachai Julanon, Mati Chuamanochan, Christopher E. M. Griffiths
Summary: This article reviews the similarities and differences between acrodermatitis continua of Hallopeau (ACH) and generalized pustular psoriasis (GPP). IL-36RN mutations are more commonly found in GPP patients, while ACH patients have a lower frequency of these mutations. Although ACH can occur before, simultaneously, or after the development of GPP, the response to treatment appears to differ between the two conditions. Based on the findings, ACH should be classified separately from GPP rather than being considered a subtype of GPP.
EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Leena Chularojanamontri, Waratchaya Panjapakkul, Chayada Chaiyabutr, Chutipon Pruksaeakanan, Supisara Wongdama, Surachanee Likittanasombat, Wimolrak Bandidniyamanon, Christopher E. M. Griffiths, Phunchai Charatcharoenwitthaya
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
A. Armstrong, K. Eyerich, C. Conrad, Y. Zhu, Y. -w. Yang, M. Miller, Y. You, Y. -k. Shen, P. Foley, C. E. M. Griffiths, B. Strober
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Teng-Chou Chen, Ting-Chun Wang, Zenas Z. N. Yiu, Meng-Sui Lee, Li-Chia Chen, K. Arnold Chan, Christopher E. M. Griffiths, Darren M. Ashcroft, Global Psoriasis Atlas GPA
Summary: This study examined the risks of serious infections and infection mortality in patients with psoriasis. The results showed that patients with psoriasis had a higher risk of serious infection and infection-related mortality, especially those with moderate-to-severe psoriasis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Rachel Sommer, Ulrich Mrowietz, Kristian Gaarn Du Jardin, Ismail Kasujee, Elisa Martini, Esteban Dauden, Gabriella Fabbrocini, Alexander Zink, Christopher E. M. Griffiths, Matthias Augustin
Summary: Psoriasis has negative impacts on physical, mental, and social health, leading to reduced quality of life. Current management of psoriasis may not adequately address all aspects of health. In order to restore or maintain health, healthcare should focus on the patient's overall well-being, including life satisfaction, quality of life, and mental well-being. This expert review emphasizes the importance of incorporating well-being into the holistic therapeutic approach for psoriasis patients, and provides recommendations for clinical practice to implement well-being assessment and treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)