Developmental Regulation of the Growth Plate and Cranial Synchondrosis

Generation ofEvc2/Limbinglobal and conditional KO mice and its roles during mineralized tissue formation

(2015) Honghao Zhang et al.   GENESIS

Wnt signaling in cartilage development and diseases: lessons from animal studies

(2015) Yu Usami et al.   LABORATORY INVESTIGATION

Deletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation

(2015) Xue Yuan et al.   PLoS One

FGFR3 induces degradation of BMP type I receptor to regulate skeletal development

(2014) Huabing Qi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes

(2014) Zi-Qiang Zhou et al.   HUMAN MOLECULAR GENETICS

Earlier Evidence of Spheno-Occipital Synchondrosis Fusion Correlates with Severity of Midface Hypoplasia in Patients with Syndromic Craniosynostosis

(2014) Jesse A. Goldstein et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

CCAAT/Enhancer Binding Protein β Regulates Expression of Indian Hedgehog during Chondrocytes Differentiation

(2014) Takahiro Ushijima et al.   PLoS One

The B55  Regulatory Subunit of Protein Phosphatase 2A Mediates Fibroblast Growth Factor-Induced p107 Dephosphorylation and Growth Arrest in Chondrocytes

(2013) V. Kolupaeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling

(2013) Jinying Piao et al.   Scientific Reports

Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification

(2012) Cheng Lu et al.   BONE

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia

(2012) Jose A. Caparrós-Martín et al.   HUMAN MOLECULAR GENETICS

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ift88 regulates Hedgehog signaling,Sfrp5expression, and β-catenin activity in post-natal growth plate

(2012) Ching-Fang Chang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base

(2011) María Pacheco et al.   BONE

The Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses

(2011) Jason Laurita et al.   DEVELOPMENTAL DYNAMICS

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia

(2011) Suzanne Rix et al.   HUMAN MOLECULAR GENETICS

The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling

(2010) Masaki Nagata et al.   BONE

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes

(2010) Diego Correa et al.   DEVELOPMENTAL CELL

Transient Activation of Wnt/β-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice

(2009) Takahito Yuasa et al.   AMERICAN JOURNAL OF PATHOLOGY

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

(2009) Yukiko Maeda et al.   BONE

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

δ-EF1 is a negative regulator ofIhhin the developing growth plate

(2009) Ellen Bellon et al.   JOURNAL OF CELL BIOLOGY

PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation

(2009) M. Zhang et al.   JOURNAL OF CELL SCIENCE

Wnt/β-catenin Signaling Regulates Cranial Base Development and Growth

(2009) M. Nagayama et al.   JOURNAL OF DENTAL RESEARCH

Roles of the Primary Cilium Component Polaris in Synchondrosis Development

(2009) T. Ochiai et al.   JOURNAL OF DENTAL RESEARCH

Parathyroid Hormone-Related Peptide Represses Chondrocyte Hypertrophy through a Protein Phosphatase 2A/Histone Deacetylase 4/MEF2 Pathway

(2009) E. Kozhemyakina et al.   MOLECULAR AND CELLULAR BIOLOGY

Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease

(2009) Iben R. Veland et al.   NEPHRON PHYSIOLOGY

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

(2008) T. Matsushita et al.   HUMAN MOLECULAR GENETICS

Inhibition of  -catenin signaling causes defects in postnatal cartilage development

(2008) M. Chen et al.   JOURNAL OF CELL SCIENCE

A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis

(2007) Liangjun Yin et al.   BONE

Wnt signaling and skeletal development

(2007) Fei Liu et al.   CELLULAR SIGNALLING