Article
Immunology
Maria Jose Bordagaray, Alejandra Fernandez, Mauricio Garrido, Jessica Astorga, Anilei Hoare, Marcela Hernandez
Summary: The study found that bacteria, especially Porphyromonas spp., were frequently detected in endodontic canals and apical lesions. Total bacteria and Porphyromonas endodontalis DNA were also found in peripheral blood mononuclear cells, indicating their potential role in bacterial systemic translocation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
William A. Chen, Yuetan Dou, Hansel M. Fletcher, Danilo S. Boskovic
Summary: P. gingivalis is a gram-negative anaerobe that causes periodontitis. It disrupts commensal interactions in the oral cavity to induce a dysbiotic, proinflammatory state. P. gingivalis avoids complete host immunosuppression to take advantage of inflammation-induced tissue damage for robust bacterial growth.
Article
Microbiology
J. Astorga, M. Hernandez, D. Bravo, A. Hoare
Summary: This study evaluated the effectiveness of two PCR primers in identifying P. endodontalis in apical periodontitis, and only one primer set showed specificity for P. endodontalis clones both in silico and in vitro.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Immunology
Marlies P. Noz, Adelina S. Plachokova, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Siroon Bekkering, Prya Vart, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen
Summary: Periodontitis-associated bacteria can induce trained immunity in monocytes, accelerating atherosclerosis development. Patients with severe periodontitis showed signs of increased systemic inflammation and hematopoietic tissue activation, but their circulating monocytes did not exhibit a hyperresponsive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
O. Barel, Y. Aizenbud, Y. Tabib, Y. Jaber, A. Leibovich, Y. Horev, K. Zubeidat, Y. Saba, L. Eli-Berchoer, O. Heyman, A. Wilensky, I Prinz, A. H. Hovav
Summary: Gamma delta T cells play various roles in the development of periodontitis, with different impacts in different models. While they are important in maintaining host-biofilm homeostasis, they can also contribute to pathological responses under specific conditions.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Microbiology
Lorena Horvat Aleksijevic, Marko Aleksijevic, Ivana Skrlec, Marko Sram, Miroslav Sram, Jasminka Talapko
Summary: Porphyromonas gingivalis is a pathogenic bacterium that can cause periodontal disease and cardiovascular problems. It can enter the bloodstream through periodontal lesions and spread to other organs, which can lead to the development of subacute endocarditis and cardiovascular diseases. P. gingivalis has several virulence and pathogenicity factors, including fimbriae, hemolysin, hemagglutinin, capsule, etc. Additionally, P. gingivalis in biofilm form is less sensitive to antimicrobial drugs, posing a challenge in treating infections caused by this bacterium.
Article
Hematology
Niema Kazem, Felix Hofer, Lorenz Koller, Andreas Hammer, Christian Hengstenberg, Alexander Niessner, Patrick Sulzgruber
Summary: In patients aged 65 and older, lymphocyte fraction, neutrophil fraction, and neutrophil-to-lymphocyte ratio were strongly and independently associated with mortality, indicating their potential as prognostic markers. Conversely, no significant effects were observed in patients under 65 years old. These findings suggest age-specific cellular immunity markers can aid in identifying high-risk individuals and informing proper secondary prevention strategies after ACS.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Shaowen Zheng, Shiwen Yu, Xiaomiao Fan, Yonghuan Zhang, Yangyang Sun, Li Lin, Hongyan Wang, Yaping Pan, Chen Li
Summary: Periodontitis is a common oral disease that affects 70% of the global population and is associated with various systemic diseases. Porphyromonas gingivalis, a gram-negative oral anaerobic bacterium, plays a crucial role in the pathogenesis of periodontitis by evading host immunity through various virulence factors, leading to periodontal tissue destruction and systemic disease connections.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Chaitanya Joshi, Ranjeet Bapat, William Anderson, Dana Dawson, George Cherukara, Karolin Hijazi
Summary: The meta-analysis showed a significant association between elevated serum IgG antibody responses (anti-Pg and anti-Aa) and CHD, suggesting their potential use as biomarkers for detecting and monitoring at-risk populations. However, inconsistencies in the design and interpretation of immunoassays highlight the need for standardization in assessing antibody responses against periodontal bacteria.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caroline Loureiro, Marilia Afonso Rabelo Buzalaf, Talita Mendes Oliveira Ventura, Vinicius Taioqui Pela, Gladiston William Lobo Rodrigues, Julia Guerra Andrade, Juliano Pelim Pessan, Rogerio Castilho Jacinto
Summary: This study quantitatively and qualitatively analyzed the proteomic profile of teeth with acute apical abscesses (AAA) and chronic apical periodontitis (CAP). The results showed significant differences in protein expression between the two groups, with AAA group mainly associated with immune inflammatory response and oxidative stress response, and CAP group mainly associated with DNA/RNA regulation and repair, and structural function.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yingle Wu, Yanyu Wang, Laijing Du, Ke Wang, Shaoxin Wang, Guangping Li
Summary: This study aimed to observe the relationship between different infection forms of Porphyromonas gingivalis (Pg), systemic inflammation, and acute myocardial infarction (AMI). The results showed that both the oral colonization and distant invasion of Pg were positively correlated with systemic inflammation and also affected the severity of coronary heart disease (CHD). The presence of Pg was likely able to drive systemic inflammation, suggesting an inflammatory relationship between periodontitis and AMI.
Article
Chemistry, Analytical
Krishnamachari Janani, Kavalipurapu Venkata Teja, Mohammad Khursheed Alam, Deepti Shrivastava, Azhar Iqbal, Osama Khattak, Khalid Al-Johani, May Othman Hamza, Jerry Jose, Mohmed Isaqali Karobari, Kumar Chandan Srivastava
Summary: The study found that oregano essential oil extract effectively inhibits bacterial LPS-induced osteoclastogenesis in a dose-dependent manner. This suggests that the extract may serve as a targeted therapeutic agent for periapical bone resorption caused by bacterial infections. Further randomized controlled studies are needed to assess its potential clinical use.
Review
Cardiac & Cardiovascular Systems
Chaitanya Joshi, Ranjeet Bapat, William Anderson, Dana Dawson, Karolin Hijazi, George Cherukara
Summary: This systematic review found a high prevalence of periodontal bacterial DNA in coronary atherosclerotic plaque specimens, with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans being the most commonly detected species. In addition to periodontal microbes, DNA from a variety of other microbes was also recovered from the collected samples.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Nutthapong Kantrong, Worakanya Buranaphatthana, Doosadee Hormdee, Waraporn Suwannarong, Rajda Chaichit, Komkham Pattanaporn, Poramaporn Klanrit, Suttichai Krisanaprakornkit
Summary: This study revealed that caspase-4 expression is diminished in gingival tissues affected by periodontitis, while IL-18 expression is enhanced. Furthermore, caspase-4 activation in P. gingivalis-infected GECs upregulates three innate immune effector molecules.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Biology
Elin Storjord, Stella Airila-Mansson, Katarzyna Karlsen, Martin Madsen, Jim Andre Dahl, Anne Landsem, Hilde Fure, Judith Krey Ludviksen, Johannes Ostrem Fjose, Amy K. Dickey, Bard Ove Karlsen, Erik Waage Nielsen, Tom Eirik Mollnes, Ole-Lars Brekke
Summary: The study found that dental health in AIP patients is associated with insulin resistance, inflammatory markers, and biomarkers of kidney and liver function.
Article
Dentistry, Oral Surgery & Medicine
Mika Huttunen, Antti Kamppi, Aapo Soudunsaari, Jari Pakkila, Leo Tjaderhane, Marja-Liisa Laitala, Vuokko Anttonen, Pertti Patinen, Tarja Tanner
Summary: Studies have found associations between self-reported physical activity and physical fitness and oral health in young men. Regular exercise is linked to a reduced need for dental restorative treatment and better dental health. Good physical fitness and higher levels of physical activity are associated with reduced caries burden.
Article
Cardiac & Cardiovascular Systems
Hirokazu Miyashita, Lauri Mansikkaniemi, Juha Sinisalo, Juhani Stewart, Petri Laine
Summary: This study compares the long-term angina pectoris relief of successful versus failed percutaneous coronary intervention of chronic total occlusions (CTO PCI). The results show that successful CTO PCI is associated with better long-term relief of symptoms of angina pectoris compared to failed CTO PCI. The all-cause death rate did not differ between the groups.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2023)
Article
Peripheral Vascular Disease
Mirjami Laivuori, Fausto Biancari, Juha Sinisalo, Anders Alback, Harri Hakovirta, Reijo Sund, Maarit Venermo
Summary: This study analyzed the impact of statin use on survival and cardiovascular mortality in patients with LEAD of different severity depicted by the ABI level. The results showed that statin use improved overall survival and amputation free survival regardless of ABI level. Statin use was also associated with lower mortality from cerebrovascular disease, overall mortality, and cardiovascular mortality in patients with ABI<0.9 or >1.3.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Jari Haukka, Juha Sinisalo
Summary: This study aimed to evaluate the long-term mortality and cause-specific mortality of patients with atrial septal defect (ASD) in a nationwide cohort. The results showed that patients with ASD had higher overall mortality, with increased cause-specific mortality in congenital malformations, stroke, and heart diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Giovanna Speranza Zabeu, Marina Ciccone Giacomini, Polliana Mendes Candia Scaffa, Leo Tjaderhane, Victor Mosquim, Linda Wang
Summary: This study aimed to determine the effectiveness of DMSO as a pretreatment to improve the mechanical properties and minimize degradation of the adhesive interface in different categories of dentin bonding systems. The results showed that incorporating DMSO improved the degree of conversion and bond strength in certain dentin bonding systems.
Review
Dentistry, Oral Surgery & Medicine
Shanon Patel, Gabriel Krastl, Roland Weiger, Paul Lambrechts, Leo Tjaderhane, Gianluca Gambarini, Peng-Hui Teng
Summary: This article represents the consensus of an expert committee convened by the European Society of Endodontology (ESE) on root resorption. It aims to provide authoritative information on the etiology, histopathology, clinical presentation, and management recommendations for root resorption based on current evidence and expert knowledge. The committee intends to update this statement as new evidence emerges.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Ida Aulanko, Enni Sanmark, Lotta Oksanen, Sampo Oksanen, Laura Lahdentausta, Anne Kivimaeki, Susanna Paju, Milla Pietiaeinen, Pirkko Pussinen, Ahmed Geneid
Summary: This study aimed to increase knowledge about the effects of the COVID-19 pandemic on working conditions in tertiary and primary healthcare. The findings demonstrate that primary healthcare workers had poorer working conditions and wellbeing compared to tertiary healthcare workers. They experienced more stress at work, had difficulty recovering from work, reported mental wellbeing below normal levels, and had increased working hours. Therefore, the study suggests that the challenges in the health and wellbeing of healthcare workers during the COVID-19 pandemic are even greater in primary care than in tertiary care.
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alejandra Fernandez, Daniela Herrera, Anilei Hoare, Marcela Hernandez, Vicente A. A. Torres
Summary: This study aimed to evaluate the angiogenesis-related effects induced by lipopolysaccharide (LPS) from Porphyromonas endodontalis and Porphyromonas gingivalis in vitro via TLR2 and TLR4. The results showed that P. endodontalis LPS stimulated endothelial cell migration and tube formation through TLR2 and TLR4 activation, while P. gingivalis LPS did not have these effects. Moreover, both LPS induced IL-6 and VEGF-A synthesis in endothelial cells.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Letter
Cardiac & Cardiovascular Systems
V Muroke, S. Tuohinen, M. Jalanko, J. Sinisalo
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Sanni Ruotsalainen, Markus Perola, Emmi Helle, Juha Sinisalo
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lili Yu, Yigit Firatli, Samira Elmanfi, Mervi Gursoy, Meltem Ozdemir Kabalak, Gokhan Kasnak, Pirkko Pussinen, Floris J. Bikker, Feriha Caglayan, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The study aimed to localize MCPIP-1 and MALT-1 in gingival tissues and profile their protein expression levels in relation to inflammation, P. gingivalis colonization, and IL-8 levels. The results showed that MCPIP-1 was present in the epithelium and connective tissue, while MALT-1 was observed in all layers of the gingival epithelium and around inflammatory cells. There was no difference in MCPIP-1 and MALT-1 levels based on gingival inflammation severity, but MALT-1 levels were elevated with an increase in P. gingivalis levels and showed an association with IL-8 levels.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Multidisciplinary Sciences
Rasmus Malmgren, Hanna Vaelimaa, Lotta Oksanen, Enni Sanmark, Petra Nikuri, Paavo Heikkilae, Jani Hakala, Aleksi Ahola, Simeoni Yli-Urpo, Ville Palomaeki, Eija Asmi, Svetlana Sofieva, Antti Rostedt, Sirpa Laitinen, Martin Romantschuk, Tarja Sironen, Nina Atanasova, Susanna Paju, Laura Lahdentausta-Suomalainen
Summary: This study investigated the generation and spread of virus-containing aerosols in dental procedures. The air-water syringe produced the highest number of aerosols and spread infectious virus-containing aerosols throughout the room. High-volume evacuation (HVE) reduced aerosol concentrations but did not fully prevent virus spread. Meticulous use of HVE, well-fitting masks, and face shields are recommended to minimize the risk of infection during dental procedures.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Constanza Jimenez, Javier Fernandez, Marcela Aroca, Maria Jose Bordagaray, Elizabeth Pellegrini, Javier Contador, Marcela Hernandez, Fernando Valenzuela, Alejandra Fernandez
Summary: This case-control study found a link between atopic dermatitis (AD) and periodontitis, with Th2-derived cytokines playing a key role in the development of both diseases. The study also found higher levels of IL-31 and TSLP in AD subjects, while severe periodontitis was associated with lower levels of IL-31.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
A. Salminen, A. M. Maatta, P. Mantyla, J. Leskela, M. Pietiainen, K. Buhlin, A. L. Suominen, S. Paju, W. Sattler, J. Sinisalo, P. J. Pussinen
Summary: This study investigates the systemic metabolic signatures of oral diseases and finds associations between current or past infectious/inflammatory oral diseases and circulating metabolites. Periodontitis, in particular, is associated with metabolic profiles typical for inflammation, suggesting that oral diseases may represent a modifiable risk factor for systemic chronic inflammation and cardiometabolic disorders.
JOURNAL OF DENTAL RESEARCH
(2023)
