Article
Biochemistry & Molecular Biology
Yi Chen, Xiaoyun Guo, Yachang Zeng, Xiaoliang Mo, Siqi Hong, Hui He, Jing Li, Rachel Steinmetz, Qinghang Liu
Summary: Excessive stimulation of β-adrenergic receptors induces ferroptosis in cardiomyocytes, contributing to catecholamine-induced cardiac injury and remodeling. Isoproterenol promotes glutathione depletion and degradation of GPX4, leading to enhanced lipid peroxidation. It also upregulates HO-1 expression and increases labile iron accumulation through heme degradation. Inhibition of ferroptosis or HO-1 activity effectively alleviates cardiac necrosis, pathological remodeling, and heart failure induced by isoproterenol administration.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yining Liu, Wenyan Chen, Yanli Cen, Xiaodeng Zhao, Zaiping Chen, Yuedong Liang, Zhongfeng Huang, Xiu He, Guanghong Yang
Summary: Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a common adverse event during tuberculosis treatment, but the underlying molecular mechanisms are unclear. This study found that ferroptosis and lipid peroxidation play a role in ATB-DILI. Treatment with anti-TB drugs led to increased lipid peroxidation and reduced antioxidant levels, along with increased expression of ACSL4 and Fe2+ concentration. The study also showed that inhibiting ferroptosis reversed drug-induced liver damage, while inducing ferroptosis exacerbated the damage. Additionally, the study found that the HIF-1 alpha/SLC7A11/GPx4 signaling pathway was inhibited by anti-TB drug treatment. Knockdown of HIF-1 alpha enhanced ferroptotic events and liver damage. These findings provide new insights into the mechanisms of ATB-DILI and suggest potential therapeutic strategies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Dongning Li, Chengzhu Song, Jie Zhang, Xiaoyan Zhao
Summary: This study demonstrates that resveratrol has protective effects against 5-FU-induced cardiotoxicity by inhibiting GPX4-dependent ferroptosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yilan Li, Jingru Yan, Qianqian Zhao, Yan Zhang, Yao Zhang
Summary: Sorafenib is a recommended drug for advanced hepatocellular carcinoma, but its use is limited due to cardiotoxicity. This study investigates the mechanism of sorafenib-induced cardiotoxicity, focusing on ferroptosis. The results show that sorafenib reduces levels of anti-ferroptotic markers and causes obvious mitochondria damage. Ferrostatin-1 can alleviate these effects by reducing ferroptosis. Furthermore, the expression of Slc7a11 is down-regulated in sorafenib-induced cardiotoxicity, and targeting ferroptosis may be a novel therapeutic approach.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaowei Zhu, Xiangfei Wang, Baoling Zhu, Suling Ding, Hongyu Shi, Xiangdong Yang
Summary: This study reveals the role of the histamine/H1R signaling pathway in doxorubicin-induced cardiotoxicity. Histamine deficiency or H1R antagonism accelerates myocardial ferroptosis and aggravates doxorubicin-induced cardiotoxicity. These findings provide a potential target for the treatment of doxorubicin-induced cardiotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Yue Li, Zhijun Huang, Shuaifei Pan, Yuhui Feng, Haokun He, Shuguang Cheng, Lijing Wang, Liping Wang, Janak Lal Pathak
Summary: The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study found that diabetic periodontitis triggers alveolar osteocyte ferroptosis and resveratrol has a therapeutic potential to alleviate osteocyte ferroptosis. The effects were observed in both mouse models and in vitro experiments.
Article
Chemistry, Medicinal
Xiaoming Jin, Riming He, Yunxin Lin, Jiahui Liu, Yuzhi Wang, Zhongtang Li, Yijiao Liao, Shudong Yang
Summary: The study found that Shenhuaifu granule (SSF) can attenuate acute kidney injury (AKI) by inhibiting ferroptosis mediated by the p53/SLC7A11/GPX4 pathway, thus serving as a preventive and therapeutic method for AKI.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Ping Huang, Han Zhao, Jinying Li, Hua Dai, Jia Wang, Chunhua Xia, Fanglan Liu
Summary: This study found that SIRT3 regulates autophagy by phosphorylation of AMPK, and promotes ferroptosis by inducing the formation of BECN1-SLC7A11 complexes. This discovery has potential therapeutic value for treating breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Yuan, Yanyu Zhai, Jingjiong Chen, Xiaofeng Xu, Hongmei Wang
Summary: The study demonstrated that oxygen-glucose deprivation/reperfusion induces ferroptosis in neurons, and kaempferol protects neurons from ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway, reducing lipid peroxidation accumulation.
Article
Neurosciences
Hua Liu, Tian-ai Zhang, Wen-Yue Zhang, Si-Rui Huang, Yue Hu, Jia Sun
Summary: The study demonstrates that Rhein, a natural anthraquinone compound, attenuates ischemic stroke-induced damage by inhibiting ferroptosis through the NRF2/SLC7A11/GPX4 axis. Rhein suppresses oxidative stress and ferroptosis-related protein expression in both in vivo and in vitro models of oxygen-glucose deprivation/reperfusion and middle cerebral artery occlusion. These findings highlight Rhein as a potential therapeutic agent for ischemic stroke.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Environmental Sciences
Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang, Xinyuan Zhao
Summary: This study reveals a novel mechanism by which antimony (Sb) triggers neurotoxicity through inducing ferroptosis in neurons by limiting the degradation of the antioxidant glutathione peroxidase 4 (GPX4). The study also found that inhibition of chaperone-mediated autophagy (CMA) can attenuate Sb-induced GPX4 degradation. These findings provide new insights into the understanding of Sb-induced neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Plant Sciences
Qiuju Li, Fu Peng, Xiaoyu Yan, Yan Chen, Jie Zhou, Shuangyue Wu, Wanyanhan Jiang, Xuhui Jin, Jie Liang, Cheng Peng, Xiaoqi Pan
Summary: This study aims to explore the effects and molecular mechanism of ferroptosis caused by aconitine. Through experiments, it was found that aconitine can induce ferroptosis by inhibiting the SLC7A11/GPX4 signal pathway, resulting in lipid peroxidation damage and iron overload. The results of this study are of great significance for understanding the neurotoxic effects of aconitine.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xue Guan, Zhonghua Li, Shu Zhu, Meijia Cheng, Yetao Ju, Lu Ren, Guanlin Yang, Dongyu Min
Summary: Galangin treatment significantly improved learning and memory in gerbils after I/R injury, reduced lipid peroxide levels, decreased cell death, and increased the expression of SLC7A11 and GPX4. Additionally, galangin inhibited ferroptosis, with its effect weakened when SLC7A11 was knocked down.
Article
Oncology
Xiaocong Mo, Di Hu, Kaisheng Yuan, Juyu Luo, Cheng Huang, Meng Xu
Summary: This study demonstrated that Tetrandrine citrate (TetC) inhibits the progression of lung adenocarcinoma (LUAD) by inducing ferroptosis. It was found that TetC caused iron overload, accumulation of reactive oxygen species (ROS), over-expression of malondialdehyde (MDA), and depletion of glutathione (GSH) in tumor cells. TetC also inhibited the expression of solute carrier family 7 (SLC7A11) and glutathione peroxidase-4 (GPX4), leading to ferroptosis.
Article
Endocrinology & Metabolism
Bingxuan Zheng, Yingcong Guo, Yuxi Qiao, Yang Li, Jin Zheng, Puxun Tian, Xiaoming Ding, Wujun Xue, Chenguang Ding
Summary: This study aimed to explore the role of ferroptosis in ischemia/reperfusion-induced acute kidney injury (AKI). Ferroptosis was observed in the renal tissue of IR rats, and miR-188-3p was found to promote ferroptosis in IR-associated AKI through downregulation of GPX4.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Chemistry, Organic
Xian Liu, Song Liu, Quanjun Wang, Gang Zhou, Lin Yao, Qin Ouyang, Ru Jiang, Yu Lan, Weiping Chen
Article
Chemistry, Organic
Xian Liu, Jialin Wen, Lin Yao, Huifang Nie, Ru Jiang, Weiping Chen, Xumu Zhang
Article
Pharmacology & Pharmacy
Hui-Fang Deng, Lan-Xin Yue, Ning-Ning Wang, Yong-Qiang Zhou, Wei Zhou, Xian Liu, Yu-Hao Ni, Cong-Shu Huang, Li-Zhen Qiu, Hong Liu, Hong-Ling Tan, Xiang-Lin Tang, Yu-Guang Wang, Zeng-Chun Ma, Yue Gao
Summary: This study demonstrated that ALI-induced cytotoxicity in renal tubular epithelial cells is assisted by mitochondrial iron overload-mediated antioxidant system inhibition, and the Nrf2-HO-1/GPX4 antioxidative system could be an important intervention target to prevent medicine containing ALI-induced nephropathy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Li-zhen Qiu, Lan-xin Yue, Yu-hao Ni, Wei Zhou, Cong-shu Huang, Hui-fang Deng, Ning-ning Wang, Hong Liu, Xian Liu, Yong-qiang Zhou, Cheng-rong Xiao, Yu-guang Wang, Yue Gao
Summary: The study found that emodin-induced oxidative stress activated ER stress and the UPR through the BiP/IRE1 alpha/CHOP signaling pathway, resulting in ER Ca2+ release and cytoplasmic Ca2+ overloading. Additionally, redox imbalance caused by emodin increased mtROS while decreasing function, leading to leakage of proapoptotic factors. Blocking Ca2+ release from ER could inhibit emodin-induced apoptosis, indicating potential targets for treatment of liver injury induced by Cassia seeds and related substances.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cardiac & Cardiovascular Systems
Yan Ma, Xian Liu, Yiming Bi, Tianhu Wang, Cheng Chen, Yabin Wang, Dong Han, Feng Cao
Summary: The study investigated the methylation modification of m(6)A mRNA in hiPSC-CMs post-TKI treatment and suggested that FTO may be a promising therapeutic target for TKI-induced cardiotoxicity. The m(6)A methylation level was significantly elevated in SUN-treated hiPSC-CMs and positively correlated with cellular damage level. Genome-wide analysis identified significant changes in m(6)A mRNA methylation peaks, with FTO being determined as cardioprotective in TKI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Organic
Xian Liu, Cheng Chen, Haohuan Yuan, Xianglin Tang, Ru Jiang, Yue Gao, Huifang Nie
Summary: In this study, we reported a straightforward and efficient synthesis of chiral alpha, gamma-disubstituted gamma-butyrolactones. The reaction achieved high yields, excellent diastereoselectivities, and high enantioselectivities through the double asymmetric hydrogenation of (E)-2-methyl-4-oxo-2-alkenoic acids using the rhodium/JosiPhos catalytic system.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Cheng Chen, Chun Yin, Yanhu Wang, Jing Zeng, Shuili Wang, Yurong Bao, Yixuan Xu, Tongbo Liu, Jiao Fan, Xian Liu
Summary: The authors established an XGBoost-based model to predict the hemorrhage risk of rivaroxaban in geriatric patients. The model showed good discrimination, accuracy, and calibration. This model facilitates individualized treatment for geriatric patients.
Article
Chemistry, Organic
Ruixia Liu, Jingkuo Han, Bin Li, Xian Liu, Zhao Wei, Jiaxin Wang, Qiaofeng Wang, Ru Jiang, Huifang Nie, Shengyong Zhang
Summary: A highly efficient intramolecular asymmetric reductive amination transformation catalyzed by an iridium complex has been achieved through a one-pot sequence. This method provides chiral tetrahydroisoquinolines in moderate to high yields and good to excellent enantioselectivities, which are important and common in natural products and biologically active molecules.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Multidisciplinary
Xian Liu, Huifang Nie, Lin Yao, Ru Jiang, Weiping Chen