Journal
ORGANIC LETTERS
Volume 24, Issue 23, Pages 4114-4118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01176
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Funding
- Natural Science Foundation of Zhejiang Province [LY22B020010]
- National Natural Science Foundation of China [21772067]
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This work reports the efficient application of N-acyloxybenzamides as acyl nitrene precursors under photoredox/iron dual catalysis. The resulting acyl nitrenes can react with various types of C-H bonds and molecules containing S or P atoms. Mechanistic investigations reveal the process of acyl nitrene formation from N-acyloxybenzamides.
In this work, the use of N-acyloxybenzamides as efficient acyl nitrene precursors under photoredox/iron dual catalysis is reported. The resulting acyl nitrenes could be captured by various types of C-H bonds and S- or P-containing molecules. Mechanism investigations suggested that the formation of the acyl nitrene from the N-acyloxybenzamide occurs by a photoredox process, and it is believed that in this redox process oxidative N-H bond cleavage of the N-acyloxybenzamide occurs prior to reductive N-O bond cleavage of the N-acyloxybenzamide.
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