Article
Oncology
Yao Xu, Fanqi Shi, Yanting Zhang, Mengfan Yin, Xiuxin Han, Jinyan Feng, Guowen Wang
Summary: This study aimed to update the recent epidemiologic estimates of malignant bone tumors. The results showed differences in incidence and mortality rates across tumor types and demographic variables, providing potential suggestions for further adjustment of medical resources.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Alicia-Marie Conway, Georgina C. Morris, Sarah Smith, Monique Vekeria, Prakash Manoharan, Claire Mitchell, Alison Backen, Pedro Oliveira, Richard A. Hubner, Angela Lamarca, Mairead G. McNamara, Juan W. Valle, Natalie Cook
Summary: A study conducted in a UK cancer center found that 34% of patients with liver-involved cancer of unknown primary (pCUP) met radiological criteria for an intrahepatic cholangiocarcinoma (iCCA) diagnosis. Patients were mostly female with an average age of 63, and both the iCCA group and the rest of the liver-involved CUP group had similar median overall survival.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Junjie Kong, Yukun Cao, Jiawei Chai, Xihan Liu, Cunhu Lin, Jianping Wang, Jun Liu
Summary: The study retrospectively analyzed the relationship between tumor size and survival in solitary ICC patients, finding tumor size to be an independent prognostic factor after resection and proposing optimal cut-off values in different subgroups. These findings suggest potential improvements to the existing AJCC staging system and highlight the importance of tumor size in predicting outcomes for ICC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Uchechukwu C. C. Megwalu, Peter K. K. Moon
Summary: Thyroid cancer incidence rates have declined since 2014, with similar declines noted for papillary thyroid carcinoma (PTC), localized disease, and tumors <= 1.0 cm, but not for tumors >2.0 cm. Incidence-based mortality rates continue to increase. These findings suggest changes in the management of thyroid nodules may have led to a decrease in the diagnosis of small indolent tumors, but not more advanced tumors.
Article
Cardiac & Cardiovascular Systems
Yuwei Zhao, Fen Qin, Qingqi Ji, Wuyan Xia, Ben He
Summary: This study found that patients with limited-stage small cell lung cancer had a higher cardiovascular mortality rate when the primary site was the main bronchus or lower lobe, compared to upper lobe and middle lobe patients. The increased risk of cardiovascular mortality post-radiotherapy was independently associated with the main bronchus/lower lobe as the primary site.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Xinxi Deng, Yang Liu, Xiangpeng Zhan, Tao Chen, Ming Jiang, Xinhao Jiang, Luyao Chen, Bin Fu
Summary: This study, using population-level data from the SEER database, showed an increasing trend in incidence-based mortality (IBM) and no significant improvement in the 5-year relative survival rate of penile cancer in the United States. The incidence of penile cancer exhibited a relatively stable trend during the study period, indicating a lack of progress in treatment and management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Avirup Guha, Michael G. Fradley, Susan F. Dent, Neal L. Weintraub, Maryam B. Lustberg, Alvaro Alonso, Daniel Addison
Summary: The incidence of atrial fibrillation (AF) is higher in breast cancer patients, particularly in those with later stages and higher grades of breast cancer. New onset AF after breast cancer diagnosis increases all-cause and cardiovascular mortality. Involving cardio-oncology in the treatment of breast cancer patients who develop AF after diagnosis is recommended to improve their cardiovascular and overall prognosis.
EUROPEAN HEART JOURNAL
(2022)
Article
Oncology
Asad Ullah, Abdul Waheed, Jaffar Khan, Ankita Mishra, Bisma Tareen, Noor Nama, Nabin Raj Karki, Muhammad Saleem Panezai, Luis Velasquez Zarate, Joseph White, Frederick D. Cason, Nathaniel Matolo, Subhasis Misra, Nagla Abdel Karim
Summary: Primary peritoneal mesothelioma (PPM) is a rare and aggressive tumor that arises from the peritoneum. This study investigated the factors affecting patient prognosis and survival in PPM. The majority of PPM patients were male and Caucasian, and the prognosis was worse for patients with poorly differentiated tumors, tumor size > 4 cm, Caucasian race, and distant spread of disease.
Article
Oncology
Xinrong Li, Yan Shao, Liqiang Sheng, Junquan Zhu, Zeming Wang, Kaibo Guo, Leitao Sun
Summary: By reviewing a large number of cases of MACUP patients and establishing prediction models, it was found that the digestive system, respiratory system, and female breast are the most common primary sites of MACUP, and different sites are significantly associated with metastasis environment and survival rate. Logistic regression models have high predictive accuracy, and decision curve analysis and clinical impact curves demonstrate clinical effectiveness.
Article
Gastroenterology & Hepatology
YiPing Chen, ShanGeng Weng
Summary: The study found that the size of solitary intrahepatic cholangiocarcinoma (ICC) tumors without vascular invasion and tumors with vascular invasion could be used as a prognostic factor for survival in ICC patients. Subdividing tumors according to size and vascular invasion could enhance the discriminatory power of the AJCC 8th edition for solitary ICC.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Masatake Matsuoka, Tomohiro Onodera, Isao Yokota, Koji Iwasaki, Yuki Suzuki, Hamasaki Masanari, Eiji Kondo, Norimasa Iwasaki
Summary: This study investigated the clinical characteristics and prognosis of bone metastatic cancer of unknown primary (CUP) using the SEER database. It found that bone metastatic CUP had a poor survival rate, but treatment interventions such as chemotherapy and radiation therapy could prolong survival in some patients.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
HongLiang Yang, Feng He, Wen Xu, Zeng Cao
Summary: Cancer of unknown primary site (CUPs) is a metastatic syndrome in which the primary tumor cannot be identified. This study retrospectively analyzed the clinical characteristics and treatment of CUPs patients, finding a close correlation between treatment outcomes and prognostic factors.
Article
Surgery
Qi Zhang, Zehan Liu, Shuangqing Liu, Ming Wang, Xinye Li, Jing Xun, Xiangyu Wang, Qin Yang, Ximo Wang, Dapeng Zhang
Summary: This study constructed a reliable nomogram for predicting the postoperative survival of patients with perihilar cholangiocarcinoma using machine learning and Cox model. The nomogram showed good discriminant ability and prediction accuracy, as evaluated by C-index, ROC curve, and calibration curve. The study identified several factors associated with the prognosis of perihilar cholangiocarcinoma, including sex, age, tumor differentiation, primary tumor stage, lymph node metastasis, TNM stage, surgery, radiation, chemotherapy, and lymph node dissection. The study also demonstrated that increasing the number of lymph node dissection had greater benefits for patients with stage T1 and N0 perihilar cholangiocarcinoma.
FRONTIERS IN SURGERY
(2023)
Article
Oncology
Wenqiang Che, Jie Liu, Tengyue Fu, Xiangyu Wang, Jun Lyu
Summary: This study provides a comprehensive understanding of the changes in the incidence and mortality of synchronous brain metastases (SBMs) over the past ten years. It reveals a significant decrease in SBMs incidence and incidence-based mortality, with lung cancer, melanoma, and breast cancer being the most common primary cancer types.
Article
Oncology
Asad Ullah, Jaffar Khan, Abdul Waheed, Nitasha Sharma, Elizabeth K. Pryor, Tanner R. Stumpe, Luis Velasquez Zarate, Frederick D. Cason, Suresh Kumar, Subhasis Misra, Sravan Kavuri, Hector Mesa, Nitin Roper, Shahin Foroutan, Nabin Raj Karki, Jaydira Del Rivero, William F. Simonds, Nagla Abdel Karim
Summary: Parathyroid carcinoma is a rare endocrine malignancy that mainly affects older Caucasian individuals with a slight male predominance. The majority of patients undergo surgery, with a 5-year survival rate of 84%. Factors such as tumor size, age, sex, race, metastasis, and tumor differentiation are associated with an increased risk of death.