Article
Medicine, Research & Experimental
Yasemin Acar, Duygu Agagunduz, Paola De Cicco, Raffaele Capasso
Summary: This paper provides a literature review on the neurological roles of flavonoids, one of the most abundant phytochemical families, in Parkinson's disease (PD). Flavonoids have been shown to have beneficial effects on PD, such as protecting dopaminergic neurons, improving motor and cognitive abilities, regulating signaling pathways, and modulating oxidative stress and neuroinflammation. In addition, flavonoids can also promote the growth of beneficial strains and reduce pathogenic strains by changing the composition of bacteria in gut microbiota.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Andrea Deledda, Giuseppe Annunziata, Gian Carlo Tenore, Vanessa Palmas, Aldo Manzin, Fernanda Velluzzi
Summary: Dietary antioxidants play a role in influencing gut microbiota composition, inflammation, and obesity, potentially impacting the development of chronic diseases related to oxidative stress and maintaining health.
Review
Microbiology
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Muruganantham Bharathi, Chaiyavat Chaiyasut
Summary: Parkinson's disease, a prevalent neurodegenerative disease, is influenced by the gut microbiota. Probiotic supplementation can improve symptoms and potentially serve as an adjunct therapy for Parkinson's disease. Further research on the role of probiotics in Parkinson's disease treatment is necessary.
Article
Biochemistry & Molecular Biology
Jose Ignacio Martinez-Montoro, Mar Quesada-Molina, Carolina Gutierrez-Repiso, Patricia Ruiz-Limon, Alba Subiri-Verdugo, Francisco J. Tinahones, Isabel Moreno-Indias
Summary: The antioxidant capacity of beer polyphenols may induce positive shifts in gut microbiota composition, and some of the observed changes may be related to metabolic status.
Review
Nutrition & Dietetics
Damiano Terenzi, Anne-Katrin Muth, Soyoung Q. Park
Summary: This paper reviews the current literature on the relationship between nutritive patterns, inflammatory markers, and the detection of Parkinson's disease (PD). The findings suggest that long-term gut inflammation may contribute to the development of PD, and specific nutritive patterns could improve gut health and reduce the risk of PD.
Review
Biochemistry & Molecular Biology
Mohamad Khalil, Hala Abdallah, Danute Razuka-Ebela, Maria Calasso, Maria De Angelis, Piero Portincasa
Summary: Given the important role of gut microbiota in host homeostasis and energy balance, changes in its composition can lead to immune-mediated inflammatory disorders and increased intestinal permeability. Za'atar, a popular plant-based food in the Eastern Mediterranean region, contains antioxidant compounds and fiber that have shown health benefits in cardiovascular and metabolic diseases. Studies have also explored the effects of Za'atar on gut microbiota and gastrointestinal diseases, especially its polyphenols. However, more research is needed on the potential clinical applications of Za'atar as a nutraceutical in gastrointestinal disorders.
Review
Biotechnology & Applied Microbiology
Shiqing Nie, Yuan Ge
Summary: The growing number of Parkinson's disease (PD) patients in an aging society puts significant pressure on society. Recent studies have shown a strong association between gut microbes and PD. Changes in gut microbiota in PD patients, such as increased pro-inflammatory microbes and decreased anti-inflammatory microbes, contribute to gut inflammation and the development of PD. Therapies based on the gut microbiome show promise in PD prevention.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Nutrition & Dietetics
Yuan Zhang, Wanpeng Yu, Lei Zhang, Man Wang, Wenguang Chang
Summary: Polyphenols have potential effects in preventing and treating neurodegenerative diseases through their influence on the microbiota-gut-brain axis, promoting the production of beneficial metabolites by gut bacteria and exhibiting various physiological functions.
Review
Biochemistry & Molecular Biology
Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
Summary: This article examines the effects of dietary polyphenols on human health, focusing on their antioxidant properties and chelating abilities. It explores the importance of polyphenols and their iron-binding abilities in inflammatory/immunomodulatory responses, with specific attention to macrophages and dendritic cells, as well as their impact on gut microbiota. The article also highlights the need for further investigation into the polyphenol-iron metabolism-inflammatory responses axis and the polyphenol-iron availability-gut microbiota relationship to prevent or counteract pathological conditions.
Article
Cell Biology
Chien-Tai Hong, Lung Chan, Kai-Yun Chen, Hsun-Hua Lee, Li-Kai Huang, Yu-Chen S. H. Yang, Yun-Ru Liu, Chaur-Jong Hu
Summary: This study demonstrated the neuroprotective effect of rifaximin in transgenic PD mice by modulating gut microbiota. Rifaximin treatment reduced systemic inflammation and protected blood-brain barrier integrity. Rifaximin treatment improved motor and memory performance in mice and increased neuronal survival in the hippocampus.
Article
Food Science & Technology
Lei Xu, Rui Wang, Yanan Liu, Shengnan Zhan, Zufang Wu, Xin Zhang
Summary: Tea polyphenols have shown memory-enhancing activities and can effectively modulate the composition of the gut microbiota. The gut microbiota plays a critical role in the development of neurodegenerative diseases by regulating brain-gut axis function. Tea polyphenols have the advantage of multi-targeting and high safety profiles, making them potential neuroprotective substances with great potential in preventing and treating neurodegenerative diseases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Neurosciences
Nehal Yemula, Celina Dietrich, Vaclav Dostal, Michael Hornberger
Summary: Parkinson's disease is closely related to the gastrointestinal tract, with initial pathophysiological changes potentially occurring in the gut before the brain. Nutrition, diet, and gut microbiome diversity could all play crucial roles in the development of PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Food Science & Technology
Yueqin Li, Yao Peng, Yingbin Shen, Yunzhen Zhang, Lianliang Liu, Xinquan Yang
Summary: Advanced glycation end products (AGEs) are formed in the reaction between reducing sugars and amino acids, and play a key role in neurodegenerative diseases. Polyphenols with multiple hydroxyl groups can inhibit the formation of AGEs and prevent neurodegenerative diseases. Regulating gut microbiota and intestinal inflammation is also a strategy for preventing neurodegenerative diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Clinical Neurology
Qing Wang, Yuqi Luo, K. Ray Chaudhuri, Richard Reynolds, Eng-King Tan, Sven Pettersson
Summary: Parkinson's disease patients show unique changes in gut microbiota, which may serve as early biomarkers of the disease. The alterations in gut microbiota composition may be related to the cause and symptoms of Parkinson's disease, but the specific mechanisms remain unclear. The microbiota-gut-brain axis provides a new pathway for understanding the pathophysiology of Parkinson's disease.
Review
Nutrition & Dietetics
Camilla Fiorindi, Edda Russo, Lucrezia Balocchini, Amedeo Amedei, Francesco Giudici
Summary: This article discusses the factors and management methods of inflammatory bowel disease, focusing on the impact of different dietary plans on gut microbiota and inflammation, aiming to better customize nutritional interventions.
Article
Biochemistry & Molecular Biology
Alessia D'Aloia, Laura Molteni, Francesca Gullo, Elena Bresciani, Valentina Artusa, Laura Rizzi, Michela Ceriani, Ramona Meanti, Marzia Lecchi, Silvia Coco, Barbara Costa, Antonio Torsello
Summary: PEA exhibits neuroprotective and anti-inflammatory effects by modulating microglial reactive phenotypes and inhibiting M1 polarization, possibly through activation of CB2R. Its effects are independent of TLR4 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Ramona Meanti, Laura Rizzi, Elena Bresciani, Laura Molteni, Vittorio Locatelli, Silvia Coco, Robert John Omeljaniuk, Antonio Torsello
Summary: Hexarelin displays inhibitory effects on H2O2-induced apoptosis in Neuro-2A cells, improving cell viability, reducing NO2- release, restoring cell morphology, and modulating apoptotic gene expression and protein kinase phosphorylation levels.
Article
Psychology, Developmental
Fahad Somaa, Andleeb Asghar, Pousette Farouk Hamid
Summary: This study investigated the relationship between emotional intelligence and academic performance, finding a positive and significant overall relationship, partially mediated by gender but not moderated by age.
DEVELOPMENTAL NEUROPSYCHOLOGY
(2021)
Review
Rehabilitation
Azka Khan, Anna Podlasek, Fahad Somaa
Summary: This literature review included 150 studies and found that virtual reality training strategies have a positive impact on stroke rehabilitation, but there is no statistically significant difference compared to standard therapy.
TOPICS IN STROKE REHABILITATION
(2023)
Review
Andrology
Vittorio Emanuele Bianchi
Summary: Alzheimer's disease is a neurodegenerative disease influenced by sex hormones. Animal models have shown that testosterone can protect neurons by reducing amyloid-beta production, improving synaptic signaling, and preventing neuronal death. Studies have found that prostate cancer patients receiving androgen deprivation therapy have a higher incidence of dementia and Alzheimer's disease. Testosterone therapy in hypogonadal men with Alzheimer's disease and cognitive impairment has shown some positive results.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Elena Bresciani, Nicola Squillace, Valentina Orsini, Roberta Piolini, Laura Rizzi, Laura Molteni, Ramona Meanti, Alessandro Soria, Giuseppe Lapadula, Alessandra Bandera, Andrea Gori, Paolo Bonfanti, Robert John Omeljaniuk, Vittorio Locatelli, Antonio Torsello
Summary: The study found that using monozygotic twins as a model can explore potential changes in miRNA regulation in HIV-infected patients after receiving cART treatment. Up-regulation of miRNAs was found to be associated with processes related to metabolism, neurogenesis, and protein phosphorylation in subcutaneous adipose tissue, with differential expression in plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ramona Meanti, Martina Licata, Laura Rizzi, Elena Bresciani, Laura Molteni, Silvia Coco, Vittorio Locatelli, Robert J. Omeljaniuk, Antonio Torsello
Summary: This study suggests that growth hormone secretagogues (GHSs) may have therapeutic potential for ALS by protecting cells from oxidative stress and promoting cell survival. Further research is needed to understand the molecular mechanisms of GHS action and develop new GHSs for ALS therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura Rizzi, Marco Turati, Elena Bresciani, Filippo Maria Anghilieri, Ramona Meanti, Laura Molteni, Massimiliano Piatti, Nicolo Zanchi, Silvia Coco, Francesco Buonanotte, Luca Rigamonti, Giovanni Zatti, Vittorio Locatelli, Robert J. J. Omeljaniuk, Marco Bigoni, Antonio Torsello
Summary: This study investigated the changes in microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and anterior cruciate ligament (ACL) rupture. The results showed that specific microRNAs were expressed differently in OA and ACL tear samples. These findings may contribute to further research on the mechanisms and treatments of osteoarthritis and ACL rupture.
Article
Medicine, General & Internal
Francesca Re, Sofia Giorgetti, Barbara Biondi, Stefano Scapin, Francesco Mantegazza, Valeria Cassina, Silvia Maria Sesana, Laura Rizzi, Ivano Eberini, Luca Palazzolo, Marten Beeg, Marco Gobbi, Marco Sardina, Massimo Masserini
Summary: The effect of bi-functionalized liposomes on the aggregation features of different amyloidogenic proteins was evaluated. The liposomes prevented the transition to fibrillar state and induced disaggregation of amyloid aggregates. The results suggest that multifunctional liposomes have anti-amyloidogenic activity and potential for treating protein-misfolding diseases.
ANNALS OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Vanessa Zambelli, Emma J. Murphy, Paolo Delvecchio, Laura Rizzi, Roberto Fumagalli, Emanuele Rezoagli, Giacomo Bellani
Summary: This study aimed to evaluate the effects of levosimendan administration on muscle contraction and diaphragm muscle cell viability in an animal model of ventilator-induced diaphragmatic dysfunction (VIDD). The results showed that levosimendan treatment preserved muscular cell structure and autophagy, but did not improve diaphragm contractile efficiency.
DRUG TARGET INSIGHTS
(2023)
Review
Cardiac & Cardiovascular Systems
Vittorio Emanuele Bianchi, Stephan von Haehling
Summary: Chronic anemia is a significant risk factor for mortality in heart failure patients, and restoring physiological levels of hemoglobin is essential. Nutritional deficits, iron deficiency, chronic kidney disease, inflammation, and hormonal imbalances are contributing factors to chronic anemia. Hormonal therapy and exercise have shown potential in improving hemoglobin levels and clinical outcomes.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)