Astragalin attenuates AlCl3/D-galactose-induced aging-like disorders by inhibiting oxidative stress and neuroinflammation

The flavonoid Astragalin shows anti‐tumor activity and inhibits PI3K/AKT signaling in gastric cancer

(2021) Zhongqing Wang et al.   Chemical Biology & Drug Design

Edaravone attenuates H2O2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl3/D-galactose induced cognitive impairment in mice

(2021) Huan-Tong Wu et al.   NEUROTOXICOLOGY

Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation

(2021) Teng-Teng Ren et al.   INFLAMMATION RESEARCH

Coeloglossum viride var. bracteatum extract improves cognitive deficits by restoring BDNF, FGF2 levels and suppressing RIP1/RIP3/MLKL-mediated neuroinflammation in a 5xFAD mouse model of Alzheimer’s disease

(2021) Xi-Xi Li et al.   Journal of Functional Foods

Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation

(2020) Yue Tong et al.   ACS Chemical Neuroscience

Reactive astrocytes display pro-inflammatory adaptability with modulation of Notch-PI3K-AKT signaling pathway under inflammatory stimulation

(2020) Ying-Ying Cheng et al.   NEUROSCIENCE

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

Coeloglossum viride var. bracteatum extract improves learning and memory of chemically-induced aging mice through upregulating neurotrophins BDNF and FGF2 and sequestering neuroinflammation

(2019) Si-Jia Zhong et al.   Journal of Functional Foods

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

(2018) Dunja Knezevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-кB pathway

(2017) Minghui Chen et al.   Oncotarget

Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo

(2017) Rui-Yuan Pan et al.   Scientific Reports

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

The Mechanism of Memory Enhancement of Acteoside (Verbascoside) in the Senescent Mouse Model Induced by a Combination ofd-gal and AlCl3

(2015) Xiao-Ming Peng et al.   PHYTOTHERAPY RESEARCH

Microglia Plasticity During Health and Disease: An Immunological Perspective

(2015) Anat Shemer et al.   TRENDS IN IMMUNOLOGY

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury

(2014) Zhen Zhang et al.   BRAIN RESEARCH

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model

(2013) Fengyang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway

(2012) Lanan Wassy Soromou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages

(2011) Mi-Sun Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Combined administration of D-galactose and aluminium induces Alzheimerlike lesions in brain

(2011) Fei Xiao et al.   Neuroscience Bulletin