Journal
NATURE REVIEWS CARDIOLOGY
Volume 19, Issue 9, Pages 567-568Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41569-022-00755-0
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Funding
- Deutsche Forschungsgemeinschaft [CRC TRR332, CRC914, CRC1009, CRC1123, OR465/1-1]
- Else Kroner Fresenius Stiftung
- IZKF at the Munster Medical Faculty
- Novo Nordisk
- Leducq Foundation
- NIH [HL107653, HL155431]
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The AIM2 inflammasome plays an important role in atherosclerosis and may be a significant target for precision medicine.
The AIM2 inflammasome is activated by host and pathogen DNA. Work from the past 5 years indicates that the AIM2 inflammasome has an important role in advanced atherosclerosis driven by clonal haematopoiesis and possibly in atherosclerosis accelerated by acute infection. Therefore, the AIM2 inflammasome might be an important target for precision medicine.
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