Inflammatory memory and tissue adaptation in sickness and in health

Lack of evidence for intergenerational inheritance of immune resistance to infections

(2022) Eva Kaufmann et al.   NATURE IMMUNOLOGY

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

(2022) Anne E. Geller et al.   Nature Communications

An in vitro chronic damage model impairs inflammatory and regenerative responses in human colonoid monolayers

(2022) William D. Rees et al.   Cell Reports

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

(2022) Xiaofei Li et al.   CELL

Trained ILC3 responses promote intestinal defense

(2022) Nicolas Serafini et al.   SCIENCE

A gene–environment-induced epigenetic program initiates tumorigenesis

(2021) Direna Alonso-Curbelo et al.   NATURE

Inflammatory adaptation in barrier tissues

(2021) Rachel E. Niec et al.   CELL

Establishment, maintenance, and recall of inflammatory memory

(2021) Samantha B. Larsen et al.   Cell Stem Cell

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

(2021) Edoardo Del Poggetto et al.   SCIENCE

Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

(2021) Ai Ing Lim et al.   SCIENCE

Insular cortex neurons encode and retrieve specific immune responses

(2021) Tamar Koren et al.   CELL

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

(2021) Gloria Pascual et al.   NATURE

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

(2021) Alice Cho et al.   NATURE

Transmission of trained immunity and heterologous resistance to infections across generations

(2021) Natalie Katzmarski et al.   NATURE IMMUNOLOGY

Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories

(2021) Kevin Andrew Uy Gonzales et al.   SCIENCE

Neonatal BCG vaccination reduces interferon gamma responsiveness to heterologous pathogens in infants from a randomised controlled trial

(2020) B Freyne et al.   JOURNAL OF INFECTIOUS DISEASES

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

(2020) Bérengère de Laval et al.   Cell Stem Cell

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

(2020) Branko Cirovic et al.   Cell Host & Microbe

Myocardial infarction accelerates breast cancer via innate immune reprogramming

(2020) Graeme J. Koelwyn et al.   NATURE MEDICINE

Pioneer Transcription Factors Initiating Gene Network Changes

(2020) Kenneth S. Zaret   Annual Review of Genetics

The maternal microbiome modulates fetal neurodevelopment in mice

(2020) Helen E. Vuong et al.   NATURE

Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development

(2020) Samuel T. Pasco et al.   Cells

Under pressure: Stem cell–niche interactions coordinate tissue adaptation to inflammation

(2020) Yue Xing et al.   CURRENT OPINION IN CELL BIOLOGY

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

(2020) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance

(2019) Rebecca S. Moore et al.   CELL

Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

(2019) Yi Wang et al.   CELL

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Cancer: the dark side of wound healing

(2018) Gopinath M. Sundaram et al.   FEBS Journal

ATF7 mediates TNF-α–induced telomere shortening

(2018) Toshio Maekawa et al.   NUCLEIC ACIDS RESEARCH

Allergic inflammatory memory in human respiratory epithelial progenitor cells

(2018) Jose Ordovas-Montanes et al.   NATURE

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Epigenetic control of innate and adaptive immune memory

(2018) Colleen M. Lau et al.   NATURE IMMUNOLOGY

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

(2018) Stephanie Fanucchi et al.   NATURE GENETICS

The Human Cell Atlas: from vision to reality

(2017) Orit Rozenblatt-Rosen et al.   NATURE

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

(2017) Shruti Naik et al.   NATURE

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

(2017) Sangdoo Kim et al.   NATURE

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Independent and additive association of prenatal famine exposure and intermediary life conditions with adult mortality between age 18–63 years

(2013) P. Ekamper et al.   SOCIAL SCIENCE & MEDICINE

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Histone modification: cause or cog?

(2011) Steven Henikoff et al.   TRENDS IN GENETICS

Resolved Psoriasis Lesions Retain Expression of a Subset of Disease-Related Genes

(2010) Mayte Suárez-Fariñas et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY